GEO DataSets

(Submitter supplied) Candida albicansis a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously,C. albicanscolonization has been shown to contribute to the progression and severity of alcoholic liver disease. However, relatively little is known about howC. albicansresponds to changing environmental conditions in the GI tract of individuals with alcohol use disorder, namely repeated exposure to ethanol. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33778

24 Samples

Download data: TXT

(Submitter supplied) Our genetic screen reveals that deletion of CTM1, which abolishes the lysine trimethylation of cytochrome c (Cyc1), results in inhibition of hyphal morphogenesis in Candida albicans. Similar results are observed in the unmethylatable Cyc1 mutant (cyc1K79A). To elucidate how unmethylated Cyc1 inhibits hyphal growth, we performed RNA-Seq analysis by comparing WT (BWP17), ctm1∆/∆, and cyc1K79A cells grown in yeast and hyphal condition. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33780

27 Samples

Download data: XLSX

(Submitter supplied) Effect of 2H on the transcription level of C. albicans

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33190

2 Samples

Download data: TXT

(Submitter supplied) We transcriptionally profiled thousands of C. albicans untreated and drug-treated cells at early and late timepoints by modifieying a single cell platform for fungal setting. Our DROP-seq set up was able to capture transcriptional signals in ~20K C. albicans . We were able to show cell-cell heterogeneity in seemingly isogenic populations of C. albicans untreated cells that coupled with cell cycle checkpoints. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32295

12 Samples

Download data: CSV

(Submitter supplied) Candida albicans is a part of the normal microbiome of human mucosa and is able to thrive in a wide range of host environments. As an opportunistic pathogen, the virulence of C. albicans is tied to its ability to switch between yeast and hyphal morphologies in response to various environmental cues, one of which includes nutrient availability. Thus, metabolic flexibility plays an important role in the virulence of the pathogen. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27535

6 Samples

Download data: XLSX

(Submitter supplied) An RNA-Seq study was undertaken to compare the global response of the fungus C. albicans to intestinal mucin (compared to control medium and medium containing glucose).

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28448

6 Samples

Download data: TXT

(Submitter supplied) Candida albicans is a member of the normal commensal flora with the ability to cause disease in susceptible individuals. Nutrient acquisition is of central importance for C. albicans to colonize and thrive in the host. We have previously assessed the role of amino acid utilization for growth and manipulation of pH, triggering the filamentation program and promoting immune evasion. While the role of amino acids has been largely studied, protein utilization has remained less well understood. more...

Organism:

Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28174

27 Samples

Download data: TXT

(Submitter supplied) Cis-2-dodecenoic acid (BDSF), a signalling molecule produced from burkholderia cenocepanic, can prevent C. albicans hyphal and biofilm formation. The mechanism of how BDSF controls C. albicans morphological switch is still unknown. To address this issue, we used DNA microarray method to investigate the changes in gene expression before and after BDSF treatment. Further, screening a mutant library based on microarray data was carried out to find the mutants unresponding to BDSF.

Organism:

Candida albicans SC5314

Type:

Expression profiling by array

Platform:

GPL27468

2 Samples

Download data: LSR, XLSX

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Candida albicans SC5314

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL19026 GPL19049

19 Samples

Download data: TXT

(Submitter supplied) The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. more...

Organism:

Candida albicans; Candida albicans SC5314

Type:

Genome variation profiling by array

Platform:

GPL19026

3 Samples

Download data: TXT

(Submitter supplied) This study shows that, in the presence of CD4+ T cells, dermal fibroblasts shift towards an antimicrobial phenotype leading to reduced dermal invasion by C. albicans. This is dependent on TLR2 activation and pro-IL-1β cleavage and results in expression of genes involved in defense against various classes of pathogens.

Organism:

Homo sapiens; Candida albicans SC5314

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL22432 GPL16791

18 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of Candida cells comparing the control vs PA treated cells

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL21258

5 Samples

Download data: TXT

(Submitter supplied) Fungal infections are a serious health problem in clinics especially in the immune-compromised patient. Disease ranges from widespread superficial infections like vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antifungals is available. The most commonly used classes of antifungal compounds used include azoles, polyenes and echinocandines. more...

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL10374

18 Samples

Download data: GPR

(Submitter supplied) The ascomycetes Saccharomyces cerevisiae, Candida albicans and Scheffersomyces stipitis metabolize the pentose sugar xylose very differently. S. cerevisiae fails to grow on xylose, while C. albicans can grow, and S. stipitis can both grow and ferment xylose to ethanol. However, all three species contain highly similar genes that encode xylose reductase and xylitol dehydrogenase required to convert xylose to xylulose, on which all three fungi grow. more...

Organism:

Saccharomyces cerevisiae; Candida albicans; Candida albicans SC5314

Type:

Expression profiling by array

Platforms:

GPL13945 GPL9818

9 Samples

Download data: TXT

(Submitter supplied) Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open reading frames, ORF19.6200, ORF19.2787 and ORF19.2336, in addition to Rbe1p and Rbt4p to a novel family of proteins. more...

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL10374

12 Samples

Download data: GPR

(Submitter supplied) Comparison of Candida albicans SC5314 treated with fludioxonil for 30 min and untreated controls under hyphae-inducing conditions

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL15859

6 Samples

Download data: TXT

(Submitter supplied) Fungal infections are a serious health problem in the clinic especially in the immunocompromised patient. Disease ranges from widespread superficial vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antimycotica are available, including azoles, polyenes, echinocandines and amphothericin B. Due to emerging resistance to standard therapy and significant side effects for some antimycotica there is a medical need for new antifungals in the clinic and general practice. more...

Organism:

Candida albicans SC5314; Candida albicans

Type:

Expression profiling by array

Platform:

GPL10374

6 Samples

Download data: GPR

(Submitter supplied) We built 3 strains from Candida albicans wild-type strains, mutant strain with one TRK1 gene deleted(one allele of two genes was deleted), overexpression strain(add one allele of the gene to rp10 locus), and restoration strain(add one allele of the gene to mutant strains). The goal is study the expression level change of genes among the three strains compared with wild-type strain on a genomic scale. more...

Organism:

Candida albicans; Candida albicans SC5314

Type:

Expression profiling by array

Platform:

GPL4920

12 Samples

Download data: GPR

(Submitter supplied) The experiment was designed to study the transcriptional profiling of Candida albicans wild-type CAI-4 strains and corresponding Histatin 5 treated strains. Since Histatin 5 will kill Candida albicans, the focus will be on how many and which genes are significantly affected with the treatment of Histatin 5. Currently, we only conducted the microarray experiments at one concentration of Histatin 5 and one time point of treatment. more...

Organism:

Candida albicans; Candida albicans SC5314

Type:

Expression profiling by array

Platform:

GPL4920

4 Samples

Download data: GPR