Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 1671

1.

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

(Submitter supplied) The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict >200 million people worldwide. By monitoring bloodstream levels of parasite-gut derived antigen, we show that from week 10 onwards an established infection with Schistosoma mansoni was cleared in an exponential manner, eliciting resistance to reinfection. Secondary challenge at week 42 demonstrated that protection was strong in all animals and complete in some. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30536
12 Samples
Download data: TXT
Series
Accession:
GSE182594
ID:
200182594
2.

A non-ribosomal peptide pheromone controls male-induced female sexual development in Schistosoma mansoni II

(Submitter supplied) βAlanyl-tryptamine (BATT) is a peptide secreted by male S. mansoni upon pairing with a female parasite. Treatment of synthetic BATT on virgin females wihtout any pairing is sufficient to induce sexual development and egg depostiion.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
6 Samples
Download data: CSV
Series
Accession:
GSE191062
ID:
200191062
3.

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via direct transcriptional regulation of meg-8.3

(Submitter supplied) The schistosome homolog of ftz-f1 is a nuclear receptor. In order to understand the function of Smftz-f1, we performed RNAseq with samples taken on two days, Day 5 and Day 9, on either control (RNAi) or Smftz-f1 (RNAi) parasites to see the transcriptional consequences of Smftz-f1 RNAi and to find potential transcriptional targets.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
12 Samples
Download data: XLSX
Series
Accession:
GSE188736
ID:
200188736
4.

A non-ribosomal peptide pheromone controls male-induced female sexual development in Schistosoma mansoni

(Submitter supplied) gli1 is a gene in the male S. mansoni required for female sexual development. As a putative transcription factor, RNAseq comparing pairs with gli1 knocked-down or control males was performed to look for the genes which are trancriptionally regulated by gli1. sm-nrps was one of the essential candidate discovered in this analysis that has been characterized in the same publication, revealing a pheromone directed novel mechanism of female schistosome sexual development.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
24 Samples
Download data: CSV
Series
Accession:
GSE184849
ID:
200184849
5.

Comparative microRNA expression profiles of Schistosoma japonicum from SCID mouse and BALB/c mouse

(Submitter supplied) Background: In immunodeficient mice, the growth and reproduction of schistosome were significantly retarded, and their virulence on the host was also weakened. Some studies have suggested that host factors including endocrine and immune signals can modulate the parasite’s development and maturation. However, it is still not clear for the molecular mechanisms underlying the growth and maturation regulation of schistosome. more...
Organism:
Schistosoma japonicum
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL25265
4 Samples
Download data: FA, TXT, XLS
Series
Accession:
GSE122318
ID:
200122318
6.

Characterization of schistosomal microRNA by species, sex and developmental stage

(Submitter supplied) To date, 115 miRNAs genes (precursors) have been registered in miRBase for Schistosoma mansoni, and 56 for Schistosoma japonicum (225 and 79 mature miRNA, respectively). miRNAs have not been systematically described in Schistosoma haematobium. Our aim in this study was to systematically characterize and quantify miRNA in Schistosoma by species, developmental stage and sex and to test the usefulness of this characterization in biomarker discovery for infection. more...
Organism:
Schistosoma japonicum; Schistosoma mansoni; Schistosoma haematobium
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL21570 GPL25265 GPL25263
60 Samples
Download data: TXT
Series
Accession:
GSE116546
ID:
200116546
7.

Comparative analysis of transcriptional profiles of Schistosoma japonicum from SCID mouse and BALB/c mouse

(Submitter supplied) Background: In immunodeficient mice, the growth and egg laying of schistosome were significantly retarded or inhibited, and their virulence on the host was also weakened. Some studies have suggested that host factors including endocrine and immune signals can modulate the parasite’s development and maturation. However, it is still not clear for the molecular mechanisms underlying the growth and maturation regulation of schistosome. more...
Organism:
Schistosoma japonicum
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25265
4 Samples
Download data: FASTA, GTF, XLS
Series
Accession:
GSE122317
ID:
200122317
8.

Single-cell analysis reveals regulation of germline stem cell fate in the human parasite Schistosoma mansoni

(Submitter supplied) Schistosomes are parasitic flatworms that cause one of the most prevalent infectious diseases from which millions of people are currently suffering. Here, we construct a cell type atlas of juvenile schistosomes to capture germline stem cells (GSCs) in the course of de novo gonadal development.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26379
29 Samples
Download data: TSV, TXT
Series
Accession:
GSE147355
ID:
200147355
9.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24248 GPL28252
15 Samples
Download data
Series
Accession:
GSE146737
ID:
200146737
10.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding [scRNA-Seq]

(Submitter supplied) In order to better understand the biology of adult schistosomes, we performed single-cell RNAseq on adult male, adult sexually-mature female, and adult virgin female parasites.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
9 Samples
Download data: RDS, XLSX
Series
Accession:
GSE146736
ID:
200146736
11.

A single-cell RNA-seq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding [RNA-Seq]

(Submitter supplied) The schistosome homolog of hnf4 is involved in parasite blood feeding and stem cell biology. In order to understand the function of hnf4, we performed RNAseq on either control(RNAi) or hnf4(RNAi) parasites to see the transcriptional consequences of hnf4 RNAi
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
6 Samples
Download data: CSV
Series
Accession:
GSE146735
ID:
200146735
12.

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite Schistosoma mansoni

(Submitter supplied) stk25 and tao genes came out of an RNAi screen in the parasitic flatworm Schistosoma mansoni, and these genes shared a similar knockdown phenotype. To test for a functional relationship, we compared transcriptomes of early knockdown worms for each gene, compared to mock controls.
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28252
12 Samples
Download data: XLSX
Series
Accession:
GSE146720
ID:
200146720
13.

Comparative analysis of microRNA expression profiles of adult Schistosoma japonicum isolated from water buffalo and yellow cattle

(Submitter supplied) To investigate microRNAs (miRNAs) involving in the regulation of the schistosome development and survival, we compared miRNA expression profiles of adult Schistosoma japonicum derived from yellow cattle and water buffalo using high-throughput sequencing with Illumina Hiseq Xten.
Organism:
Schistosoma japonicum
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL25984
8 Samples
Download data: TXT
Series
Accession:
GSE124351
ID:
200124351
14.

Transcriptomic analysis of reduced sensitivity to praziquantel in Schistosoma mansoni

(Submitter supplied) Schistosomiasis is a chronic neglected tropical disease caused by digenetic parasitic flatworms of the genus Schistosoma. The disease is estimated to affect over 206 million people, the majority of whom live in Africa where Schistosoma mansoni and Schistosoma japonicum are the major causative agents. While a number of drugs have been used to treat schistosomiasis, praziquantel (PZQ) is the only one that is widely available, relatively cheap, and easy to use. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
24 Samples
Download data: XLSX
Series
Accession:
GSE120682
ID:
200120682
15.

Single-cell RNA sequencing of proliferative stem cell population from juvenile Schistosoma mansoni worms

(Submitter supplied) The rise of single-cell RNA sequencing (scRNAseq) technologies has enabled researchers to classify cell types, delineate cell developmental trajectories, and measure molecular responses to external perturbations. These technologies all rely on the premise that cell-to-cell variations arising from the biological processes of interest are clearly distinguishable from the intrinsic transcriptional and technical noise. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL26379 GPL24248
737 Samples
Download data: CSV, FA, TXT
Series
Accession:
GSE116920
ID:
200116920
16.

Transcriptome analysis of females and males following knockdown serine/threonine protein phosphatase 1 catalytic subunit encoding genes(Sj-pp1c) in Schistosoma japonicum

(Submitter supplied) Purpose: To obtain the differentially expressed genes based on post-RNAi transcriptional profiling analysis of females and males, which provide a more comprehensive overview about the effects of Sj-pp1c knockdown on schistosoma developmental and reproduction biology at the molecular level. Methods: Schistosoma japonicum females and males were collected from 21 days post infection worm pairs that untreated (Blank,BLA_FE/M) or treated with combined Sj-pp1c dsRNAs (Sj-pp1c KD,PP1_FE/M) cultured for 7 d in vitro. more...
Organism:
Schistosoma japonicum
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20772
12 Samples
Download data: TXT
Series
Accession:
GSE108738
ID:
200108738
17.

Transcriptional Profiling of Schistosoma mansoni f zfp-1-1(RNAi) parasites

(Submitter supplied) We distrupted the expression of the Schistosoma mansoni zfp-1-1 gene using RNA interference and examined the transcriptional effects by illumina sequencing
Organism:
Schistosoma mansoni
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24248
6 Samples
Download data: XLSX
Series
Accession:
GSE106693
ID:
200106693
18.

Analysis of gene expression among schistosoma japonicum from different hosts

(Submitter supplied) The microarray analysis of gene expression difference between cattle,buffalo and goat,provide us a profiling as a new platform to discover the difference between their compatibility
Organism:
Schistosoma japonicum
Type:
Expression profiling by array
Platform:
GPL10987
9 Samples
Download data: TXT
Series
Accession:
GSE24615
ID:
200024615
19.

Gene expression profiles of Schistosoma japonicum in four developmental stages

(Submitter supplied) In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.
Organism:
Schistosoma japonicum
Type:
Expression profiling by array
Platform:
GPL18617
23 Samples
Download data: PAIR
Series
Accession:
GSE57143
ID:
200057143
20.

Schistosomula exposed to HDAC inhibitor (Trichostatin A)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Schistosoma mansoni
Type:
Expression profiling by array
Platform:
GPL22001
18 Samples
Download data: TXT
Series
Accession:
GSE83211
ID:
200083211
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid31245[Organism]|query=1|qty=7|blobid=MCID_61f44ee7b74e245a0d22916e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center