txid32630[Organism] - GEO DataSets

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Select item 2002559411.

miRNA array in the A549 Ago2-KO/HA-Ago2Wt, Ago2-KO/HA-Ago2KA, and Ago2-KO/HA-Ago2Δ (Dm) cells

(Submitter supplied) We used miRNA microarrays to detail the miRNA content in A549 Ago2-KO/HA-Ago2Wt, Ago2-KO/HA-Ago2KA, and Ago2-KO/HA-Ago2Δ (Dm) cells

Organism:: synthetic construct; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL19117
9 Samples

Download data: CEL, XLSX

Series

Accession:: GSE255941

ID:: 200255941

Analyze with GEO2R

Select item 2002395992.

plasma exosome from mice bearing Ago2wt and Ago2dm tumor

(Submitter supplied) Exosomes are small membrane bound cell-derived vesicles that are present in biological fluids include blood and cell culture medium. Exosomes contain various functional proteins, mRNAs and microRNAs (miRNAs). We used miRNA microarrays to detail the miRNA content in plasma exosomes of mice bearing A549Ago2-KO/HA-Ago2Wt and A549Ago2-KO/HA-Ago2Δ (Dm) tumors.

Organism:: synthetic construct; Mus

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE239599

ID:: 200239599

Analyze with GEO2R

Select item 2002394993.

miRNA differentially expressed in P2-peptide and P2S-peptide treated A549 cancer cells.

(Submitter supplied) To determine the role of Ago2/Cav1 interaction in Ago2 function, we used miRNA arrays to examine the levels of miRNA in cancer cells whose Ago2/Cav1 interaction was inhibited by P2 or P2S peptides. Disruption of Ago2/Cav1 interaction by P2 peptides resulted in fluctuations in different miRNAs in cancer cells

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
6 Samples

Download data: CEL, XLSX

Series

Accession:: GSE239499

ID:: 200239499

Analyze with GEO2R

Select item 2002616884.

Expression data from adipose tissue macrophages of mice with or without moderate aerobic exercise

(Submitter supplied) ATMs, which can constitute up to 50% of the cells in adipose tissue of obese mice 5, play a pivotal role in both metabolic and immune regulation of adipose tissue. This is particularly evident in both healthy states and in conditions associated with metabolic syndrome. To delve into the precise mechanisms of the ATMs in response to exercise, we utilized exercise-induced primary ATMs and miRNAs microarray to investigate the effects of an 8-week aerobic exercise training on ATMs. more...

Organism:: Mus musculus; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
6 Samples

Download data: CEL

Series

Accession:: GSE261688

ID:: 200261688

Analyze with GEO2R

Select item 2002639215.

Profiling of exosomal microRNAs expression in culture medium of human esophageal cancer cell lines under hypoxic conditions

(Submitter supplied) The purpose of this analysis is to analyze the changes that occur in microRNAs contained in exosomes released from cancer cells in the tumor hypoxic environment of esophageal squamous cell carcinoma(ESCC). We used microarrays to perform a comprehensive analysis of microRNAs in exosomes released from human ESCC cell lines under normoxic or hypoxic conditions.

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
4 Samples

Download data: CEL, XLSX

Series

Accession:: GSE263921

ID:: 200263921

Analyze with GEO2R

Select item 2002252636.

Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [MPRA]

(Submitter supplied) Although acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understanding of the contribution of inherited genetic variation on inter-individual differences in chemotherapy response, and defining genetic factors impacting therapy failure can help better predict response and identify drug resistance mechanisms. Using inherited noncoding variants associated with chemotherapeutic drug resistance and/or treatment outcome, we mapped these variants to ALL cis-regulatory elements and investigated their gene regulatory potential and genomic connectivity using massively parallel reporter assays and promoter capture Hi-C, respectively. more...

Organism:: Homo sapiens; synthetic construct

Type:: Other

Platforms:: GPL26526 GPL24676
64 Samples

Download data: TSV, TXT

Series

Accession:: GSE225263

ID:: 200225263

Select item 2002242047.

Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL26526 GPL20301 GPL24676
117 Samples

Download data: BEDPE, BIGWIG, BW, NARROWPEAK, TXT

Series

Accession:: GSE224204

ID:: 200224204

Select item 2002458738.

miRNA expression data from HPC-EVs

(Submitter supplied) EVs derived from HPCs could affect the progression of S. japonicum-induced fibrosis. Considering the EVs’ cargo, small RNAs account for a large proportion of cargoes in EVs, and act as one of the critical post-transcriptional regulators in cell-to-cell communication. Among them, miRNAs are the most studied and their regulatory roles in host–pathogen interactions are increasingly clear. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. more...

Organism:: Rattus norvegicus; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
6 Samples

Download data: CEL

Series

Accession:: GSE245873

ID:: 200245873

Analyze with GEO2R

Select item 2002270879.

Transfer learning enables identification of multiple types of RNA modification using nanopore direct RNA sequencing

(Submitter supplied) RNA internal modifications play critical role in development of multicellular organisms and their response to environmental cues. Using nanopore direct RNA sequencing (DRS), we constructed a large in vitro epitranscriptome (IVET) resource from plant cDNA library labeled with m6A, m1A and m5C respectively. Furthermore, after transfer learning, the pre-trained model was used to detect additional RNA internal modification such as m1A, hm5C, m7G and Ψ modification. more...

Organism:: Oryza sativa; synthetic construct

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL25738 GPL33241
8 Samples

Download data: FA, TXT

Series

Accession:: GSE227087

ID:: 200227087

Select item 20026090910.

Exosomal miRNA profiling in Bcl-w overexpressed U251cells

(Submitter supplied) Exosomes are cell membrane-derived endoplasmic reticulum measuring 30 to 120 nm, which are secreted from various cells including cancer cells, and consist of lipids, proteins, mRNAs, and microRNAs (miRNAs). Tumor-derived exosomes are involved in tumor progression by delivering various factors to neighboring cells and promoting intercellular communication. MiRNA is a non-coding RNA consisting of 20-24 nucleotides that binds to the 3'UTR region of the target gene with a complementary nucleotide sequence during gene expression to degrade target mRNA or inhibit translation into target protein. more...

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
2 Samples

Download data: CEL

Series

Accession:: GSE260909

ID:: 200260909

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20025406811.

miR-619-5p and cardiogenic shock in patients with ST-Segment-Elevation Myocardial Infarction

(Submitter supplied) Affymetrix microarray (GeneChip microRNA 4.0) profilling of circulating miRNAs. We used miRNA arrays to profile miRNAs isolated from plasma of ST-segment elevation acute myocardial infarction (STEMI)-patients with cardiogenic shock (CS) or without cariogenic shock (Non-CS)

Organism:: synthetic construct; Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL21572
20 Samples

Download data: CEL, CHP

Series

Accession:: GSE254068

ID:: 200254068

Analyze with GEO2R

Select item 20017812612.

Circulating miRNA profile and coronary calcification in asymptomatic patients with familial hypercholesterolemia.

(Submitter supplied) Affymetrix microarray (GeneChip microRNA 4.0) profilling of circulating miRNAs. We used miRNA arrays to profile miRNAs isolated from plasma from familial hypercholesterolemia patients with (FH-W_CCS) or without (FH-WO_CCS) coronary calcium score by computed tomographic angiography

Organism:: Homo sapiens; synthetic construct

Type:: Non-coding RNA profiling by array

Platform:: GPL19117
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE178126

ID:: 200178126

Select item 20026233313.

Mining novel gene targets for improving tolerance to furfural and acetic acid in Yarrowia lipolytica using whole-genome clustered regularly interspaced short palindromic repeats interference library [CRISPR screen]

(Submitter supplied) Lignocellulosic biomass is an abundant renewable resource with tremendous potential to alleviate climate crisis. Yarrowia lipolytica is an attractive biochemical production host, while the presence of inhibitors furfural and acetic acid in lignocellulosic hydrolysate restricts the efficient utilization of this resource. Given a deficient understanding of the inherent interactions between these inhibitors and cellular metabolism, sufficiently mining relevant genes is necessary. more...

Organism:: synthetic construct

Type:: Other

Platform:: GPL26697
3 Samples

Download data: XLSX

Series

Accession:: GSE262333

ID:: 200262333

Select item 20026206014.

Functional activity scores of a DMS library representing coding single residue substitution variants in the transcription factor CRX measured in an engineered reporter cell line

(Submitter supplied) Cone-Rod Homeobox, encoded by CRX, is a transcription factor (TF) essential for the terminal differentiation and maintenance of mammalian photoreceptors. Although a handful of human variants in CRX have been shown to cause several different degenerative retinopathies with varying cone and rod predominance, as with most human disease genes the vast majority of observed CRX genetic variants are uncharacterized variants of uncertain significance (VUS). more...

Organism:: synthetic construct; Homo sapiens

Type:: Other

Platforms:: GPL19424 GPL34318 GPL34284
18 Samples

Download data: PARQUET, TSV

Series

Accession:: GSE262060

ID:: 200262060

Select item 20025602915.

The disordered extensions of the Arid5a core ARID domain modulate its DNA- and RNA-binding propensities

(Submitter supplied) ARID (AT-rich interacting domain) proteins are a heterogeneous family of DNA-binding proteins involved in transcriptional regulation. No precise DNA-binding preferences have yet been defined for the aberrant member Arid5a. In addition, the protein binds to mRNA motifs for transcript stabilisation, presumably through the DNA-binding ARID domain. Here we first provide an unbiased definition of RNA motifs and a clear breakdown of nucleic acid binding by the ARID domain. more...

Organism:: synthetic construct

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27484
4 Samples

Download data: XLSX

Series

Accession:: GSE256029

ID:: 200256029

Select item 20025358016.

Deep mutational scanning quantifies DNA binding and predicts clinical outcomes of PAX6 variants

(Submitter supplied) Nonsense and missense mutations in the transcription factor PAX6 cause a wide range of eye development defects, including aniridia, microphthalmia and coloboma. To understand how changes of PAX6:DNA binding cause these phenotypes, we combined saturation mutagenesis of the paired domain of PAX6 with a yeast one-hybrid (Y1H) assay in which expression of a PAX6-GAL4 fusion gene drives antibiotic resistance. more...

Organism:: synthetic construct; Saccharomyces cerevisiae

Type:: Other

Platforms:: GPL31112 GPL26302 GPL33815
15 Samples

Download data: CSV, TSV

Series

Accession:: GSE253580

ID:: 200253580

Select item 20025353617.

RNA-binding preference of the Roquin-1 CCCH-type zinc finger

(Submitter supplied) Zinc finger (ZnF) domains are widespread RNA-binding domains, recognizing single stranded and double stranded RNAs. Together with other RNA-binding domains, ZnFs enhance the affinity and specificity of RNA-binding proteins (RBPs). The ZnF-containing RBP Roquin controls mRNA decay by recognizing stem-loop elements in the 3'-UTR of its target mRNAs. Stem-loop elements are bound in a shape-specific manner by the unique ROQ domain with nanomolar affinity. more...

Organism:: synthetic construct

Type:: Other

Platform:: GPL27484
4 Samples

Download data: XLSX

Series

Accession:: GSE253536

ID:: 200253536

Select item 20023070718.

Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids

(Submitter supplied) We developed novel chemically defined recipe media named NPSR-v2, that was capable of expanding mouse and human nephron progenitor cells (NPC) for long term culture in vitro in 2D (2 Dimension) format. NPSR-v2 and these expanded NPC can be used for versatile application, such as reprograming, whole genome-wide CRISPR screen, kidney-associated disease modeling and library drug screening etc.

Organism:: synthetic construct; Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

4 related Platforms
63 Samples

Download data: XLSX

Series

Accession:: GSE230707

ID:: 200230707

Select item 20022800119.

An extended wave of global mRNA deadenylation sets up a switch in translation regulation across the mammalian oocyte-to-embryo transition

(Submitter supplied) The oocyte-to-embryo transition (OET) occurs in the absence of new transcription and relies on post-transcriptional gene regulation, including translational control by mRNA poly(A) tail regulation, where cytoplasmic polyadenylation activates translation and deadenylation leads to translational repression and decay. However, how the transcriptome-wide landscape of mRNA poly(A) tails shapes translation across the OET in mammals remains unknown. more...