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Items: 1 to 20 of 4381501

1.

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
33 Samples
Download data
Series
Accession:
GSE185983
ID:
200185983
2.

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [cell line]

(Submitter supplied) Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDCs). BPDCN occurs at least three times more frequently in men than women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-associated mutations, we link acquired alterations in RNA splicing to abnormal pDC development and inflammatory response through Toll-like receptors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: XLSX
Series
Accession:
GSE185982
ID:
200185982
3.

For lncRNA, circRNA and mRNA sequencing of TAO patients and normal people

(Submitter supplied) We identified the differentially expressed mRNAs and lncRNAs/circRNAs of the case group and the control group through high-throughput sequencing technology, performed a functional enrichment analysis of the differentially expressed genes, and used protein-protein interaction (PPI) analysis to identify the hub genes. A novel ceRNA network was successfully established, and the network components may serve as promising diagnostic biomarkers or therapeutic targets for TAO in the future.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL30862
6 Samples
Download data: TXT
Series
Accession:
GSE185952
ID:
200185952
4.

Anabolic resistance of skeletal muscle in cancer cachexia is caused by impaired IGF1 expression to mechanical loading

(Submitter supplied) Cachexia is a systemic metabolic syndrome characterized by loss of fat and skeletal muscle mass in chronic wasting diseases such as cancer. The regulation of cellular protein synthesis in response to workload in skeletal muscle is generally blunted in cancer cachexia; however, the precise molecular regulation is largely unknown. In this study, to examine the molecular mechanism of skeletal muscle protein metabolism in cancer cachexia, we analyzed comprehensive gene expression in skeletal muscle using microarrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
2 Samples
Download data: TXT
Series
Accession:
GSE185934
ID:
200185934
5.

Co-expression network analysis of frontal cortex during the progression of Alzheimer’s disease   

(Submitter supplied) Using WGCNA and enrichment analyses to identify pathway level differences between individuals with no cognitive impairment, mild cognitive impairment, and Alzheimer’s disease. Frozen frontal cortex (BA10) tissue from NCI, MCI, and mild/moderate AD cases (n = 12/group) representing both genders was acquired postmortem from participants in the Rush Religious Orders Study, a longitudinal clinical pathologic study of aging and AD in elderly Catholic clergy
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16025
35 Samples
Download data: CALLS, PAIR
Series
Accession:
GSE185909
ID:
200185909
6.

Engineering Extracellular Vesicles by Three-dimensional Dynamic Culture of Human Mesenchymal Stem Cells

(Submitter supplied) In current study, hMSCs were grown as 3D aggregates under wave motion to promote EV secretion (3D EVs). mRNA sequencing reveals global transcriptome alterations (e.g., upregulated Wnt, TNF, and Hippo signaling and downregulated cellular senescence) for 3D aggregates.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
21 Samples
Download data: XLSX
Series
Accession:
GSE185874
ID:
200185874
7.

SFPQ-ABL1 and BCR-ABL1 utilise different signalling networks to drive B-cell acute lymphoblastic leukaemia

(Submitter supplied) Purpose: We identified a rare instance of the SFPQ-ABL1 in a child with Ph-like ALL. The overall purpose of this study was to compare the structure and function of the SFPQ-ABL1 fusion to the well characterised BCR-ABL1 fusion. We used phosphoproteomics, transcriptomics and functional assays to determine the transforming capacity, subcellular localisation, and signalling networks of these two fusions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: TXT
Series
Accession:
GSE185860
ID:
200185860
8.

Screening for potential target genes of hsa-mir-199a-1 and hsa-mir-4423 using Clariom D arrays

(Submitter supplied) We screened for target genes of hsa-mir-199a-1 and hsa-mir-4423 by transcriptome profiling. The miRNAs were overexpressed in HeLa cells by transient transfection of precursor miRNA expression plasmids. High-density Clariom D arrays for human were used for the gene expression analysis. This GEO entry provides the microarray data preprocessed according to the gene level workflow.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL23126
18 Samples
Download data
Series
Accession:
GSE185859
ID:
200185859
9.

Epigenetic signature induced by prolonged culture may impact therapeutic function of Tregs used in adoptive cell therapy

(Submitter supplied) Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions. To reach sufficient cell yield for treatment, ex vivo isolated autologous or allogenic Tregs need to be expanded extensively in vitro during manufacturing of the Treg product. However, repetitive cycles of restimulation and prolonged culture have been shown to impact T cell phenotypes, functionality and fitness. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
83 Samples
Download data
Series
Accession:
GSE185854
ID:
200185854
10.

JAK/STAT blockade in cHL

(Submitter supplied) Here we investigated the effects of JAK/STAT pharmacological inhibition on cHL cell models using ruxolitinib, a JAK 1/2 inhibitor. We use five classical Hodgkin lymphoma cell lines: L428, L1236, L540, KMH2, L591
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
25 Samples
Download data
Series
Accession:
GSE185818
ID:
200185818
11.

Cardiomyocyte TLR4 regulates autophagy through TRAF6-mediated TFEB ubiquitination in sepsis-associated cardiac dysfunction

(Submitter supplied) Sepsis-associated cardiac dysfunction (SACD) is the predominant cause of death in sepsis patients with undefined mechanism of inflammation-autophagy interaction to date. Herein, time-course analysis of cardiac autophagy was conducted in a mouse model of SCAD. An in vitro model established by Lipopolysaccharide-induced macrophage conditioned media stimulation on cardiomyocytes was further investigated for molecular insights. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: TXT
Series
Accession:
GSE185754
ID:
200185754
12.

Transcriptome-wide Mapping of N6‑Methyladenosine via a Three-step Chemical Labeling Method

(Submitter supplied) We present a chemical method (m6A-ORL-Seq) for transcriptome-wide mapping of m6A, and compared its results with MeRIP-seq.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL20795
12 Samples
Download data
Series
Accession:
GSE185753
ID:
200185753
13.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL18573
48 Samples
Download data
Series
Accession:
GSE185747
ID:
200185747
14.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ls180]

(Submitter supplied) Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: TXT, XLS
Series
Accession:
GSE185745
ID:
200185745
15.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ht115]

(Submitter supplied) Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
15 Samples
Download data: TXT
Series
Accession:
GSE185744
ID:
200185744
16.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [v5_chip]

(Submitter supplied) Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
11 Samples
Download data
Series
Accession:
GSE185739
ID:
200185739
17.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [h3k27ac]

(Submitter supplied) Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
10 Samples
Download data
Series
Accession:
GSE185736
ID:
200185736
18.

Characterization of genomic rearrangements in RPE-1 cells with and without DSB in the ABCB1 promoter

(Submitter supplied) The discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR) and its development as a genome editing tool has revolutionized the field of molecular biology. In the DNA damage field, CRISPR has brought an alternative to induce endogenous double-strand breaks (DSB) at desired genomic locations and study the DNA damage response and its consequences. Many systems for sgRNA delivery have been reported in order to efficiency generate this DSB, including lentiviral vectors. more...
Organism:
Homo sapiens
Type:
Other; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
11 Samples
Download data
Series
Accession:
GSE185725
ID:
200185725
19.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data
Series
Accession:
GSE185724
ID:
200185724
20.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [sorted_BM_PB_THY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Download data: RDATA
Series
Accession:
GSE185723
ID:
200185723
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