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Items: 1 to 20 of 4779665

1.

PARP1 gene knockout suppresses expression of DNA Base Excision Repair genes

(Submitter supplied) PARP1 is a member of various DNA repair pathways - main target for anti-cancer treatment.  We evaluated the effect of topotecan and TDP1 Inhibitor in HEK293 wild-type and PARP1 knockout cells on the gene expression
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30209
40 Samples
Download data: TSV
Series
Accession:
GSE218871
ID:
200218871
2.

RNASeq of RNA from blasted CD4+ T cells from individuals with TCF3 mutations and healthy controls

(Submitter supplied) RNA-seq was performed using RNA extracted from blasted CD4+ T cells from individuals with TCF3 (haploinsufficiency [HI], null, or dominant negative [DN] mutations and healthy controls for the following study groups: healthy controls (HC, n=4) and patients with TCF3 mutations (HI=4, null=1, DN=1 ). Libraries were prepared using the AmpliSeq for Illumina Transcriptome Human Gene Expression panel. RNA-seq was performed on the Illumina HiSeq 2500 (Illumina; AmpliSeq for Illumina/HiSeq 2500). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
20 Samples
Download data
Series
Accession:
GSE218787
ID:
200218787
3.

Single-cell transcriptional atlas revealed that the resident progenitor cell niche functions in TMJ disc development and injury

(Submitter supplied) The biological characteristics of the temporomandibular joint (TMJ) disc involve complex changes in cell identity and extracellular matrix (ECM) composition to modulate jaw function during postnatal growth and aging. To better understand this process, we profiled and analyzed 39111 single-cell transcriptomes of TMJ disc cells from mice at different postnatal stages. Our data showed that TMJ disc cells are composed of 9 distinct clusters that can be divided into 4 principal cell types: fibroblasts (FBs), which were the most abundant, endothelial cells (ECs), macrophages (MPhs) and mural cells (MCs). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
5 Samples
Download data
Series
Accession:
GSE218785
ID:
200218785
4.

Deacetylation of HP1g enhances multiple myeloma drug resistance through DNA damage repair and liquid-liquid phase separation (ChIP-seq)

(Submitter supplied) Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that HP1g coordinates histone H3 lysine 9 trimethylation (H3K9me3) to regulate chromatin dynamic and gene transcription during bortezomib resistance.Mechanistically, HP1g can interact with H3K9me3, its CD domain is responsible to read H3K9me3 to serve its function.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20795
2 Samples
Download data
Series
Accession:
GSE218772
ID:
200218772
5.

The m6A methyltransferase METTL3 participate in the attenuated effect of BPA on learning and memory in rat

(Submitter supplied) Bisphenol A (BPA), a widely used endocrine disruptor, has been implicated in cognitive impairment via epigenetic machinery. N6-methyladenosine (m6A) has recently emerged as a new epigenetic factor that negatively influencing cognition, but the role of m6A in BPA induced cognitive deficits has not been explored yet.Here, m6A sequencing in total RNA of neurons after BPA exposure was performed and compare.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL25947
4 Samples
Download data
Series
Accession:
GSE218690
ID:
200218690
6.

Decreasing Mutant ATXN1 Nuclear Localization Improves a Spectrum of SCA1-Like Phenotypes and Brain Region Transcriptomic Profiles

(Submitter supplied) Spinocerebellar ataxia type 1 (SCA1) is a dominant trinucleotide repeat neurodegenerative disease characterized by motor dysfunction, cognitive impairment, and premature death. Degeneration of cerebellar Purkinje cells is a frequent and prominent pathological feature of SCA1. We previously showed that transport of ATXN1 to Purkinje cell nuclei is required for pathology, where mutant ATXN1 alters transcription. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
120 Samples
Download data: TXT
Series
Accession:
GSE218303
ID:
200218303
7.

Gene expression profile at single cell level of periheral blood mono-nucleus cells (PBMC) in response to bacterial protein (PFOR) stimulation

(Submitter supplied) We identified Pyruvate:Ferredoxin Oxidoreductase (PFOR) as a bioactive protein from Faecalibacterium prausnitzii. We usd single cell transcriptome sequencing to fully evaluate the PFOR's effect on PBMC.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20795
2 Samples
Download data
Series
Accession:
GSE217868
ID:
200217868
8.

Single-nucleus transcriptomics atlas of middle and late prenatal human cortical development

(Submitter supplied) Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. However, systematic single-cell analyses to resolve cellular diversity and gliogenic lineages of the third trimester are lacking. Here, we present a comprehensive single-nucleus RNA sequencing atlas derived from the proliferative germinal matrix and laminating cortical plate of 15 prenatal, non-pathological postmortem samples and 3 adult controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
36 Samples
Download data: CSV, XLSX
Series
Accession:
GSE217511
ID:
200217511
9.

Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.

(Submitter supplied) Controlled recruitment of C-C Motif Chemokine Receptor 2 (CCR2)-positive monocytes into lung tissues is a crucial component of the host immune response to infections. Pathogenesis of cystic fibrosis (CF) lung remodeling, which ultimately leads to respiratory failure, is caused by chronic infections and neutrophilic inflammation, but the immune mechanisms are not fully understood. Here, we show that lung explants from CF patients with severe disease contain abundant CCR2-positive classical monocytes in the submucosal tissues of small airways and areas of tissue remodeling. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
32 Samples
Download data: TXT
Series
Accession:
GSE217102
ID:
200217102
10.

Gene expression profiling analysis of laryngeal cancer

(Submitter supplied) To investigate the metabolic mechanisms of laryngeal cancer. We then performed gene expression profiling analysis using data obtained from ten tumor tissue samples and ten nontumor tissue samples.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
20 Samples
Download data: TXT
Series
Accession:
GSE216664
ID:
200216664
11.

Effects of glutamate release inhibition on the transcriptome of BA-NAc neurons

(Submitter supplied) Reduced reward interest/learning and reward-to-effort valuation are distinct, common symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological factor. Pyramidal glutamate neurons in the basal amygdala (BA) project to various brain regions including nucleus accumbens (NAc). The BA-NAc neural pathway is activated by reward and aversion, with many neurons being monovalent. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: RDS
Series
Accession:
GSE216588
ID:
200216588
12.

Effects of Chronic Social Stress on the transcriptome of BA-NAc neurons

(Submitter supplied) Reduced reward interest/learning and reward-to-effort valuation are distinct, common symptoms in neuropsychiatric disorders for which chronic stress is a major aetiological factor. Pyramidal glutamate neurons in the basal amygdala (BA) project to various brain regions including nucleus accumbens (NAc). The BA-NAc neural pathway is activated by reward and aversion, with many neurons being monovalent. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
33 Samples
Download data: RDS
Series
Accession:
GSE216587
ID:
200216587
13.

PHD2 constrains the anti-tumor CD8+ T cell activity

(Submitter supplied) The PHD/HIF pathway has been implicated in a wide range of immune and inflammatory processes, including in the oxygen‐deprived tumor microenvironment. To examine the effect of HIF stabilization in anti‐tumor immunity, we deleted Phd2 selectively in T lymphocytes using the cre/lox system. We show that the deletion of PHD2 in lymphocytes resulted in enhanced regression of EG7‐OVA tumors, in a HIF‐1adependent manner. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
5 Samples
Download data: XLSX
Series
Accession:
GSE216536
ID:
200216536
14.

Epigenome-wide Association Study of Physical Activity and Physiological Parameters in Discordant Monozygotic Twins

(Submitter supplied) An epigenome-wide association study (EWAS) was performed on buccal cells from monozygotic-twins (MZ) reared together as children, but who live apart as adults. Cohorts of twin pairs were used to investigate associations between neighborhood walkability and objectively measured physical activity (PA) levels. Due to dramatic cellular epigenetic sex differences, male and female MZ twin pairs were analyzed separately to identify differential DNA methylation regions (DMRs). more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL16791
140 Samples
Download data: CSV
Series
Accession:
GSE216387
ID:
200216387
15.

Tenofovir Alafenamide With Fine Needle Aspiration Biopsy in Chronic Hepatitis B

(Submitter supplied) The objective of this study is to identify immunological mechanisms that contribute to normalization of liver inflammation in chronic hepatitis B (CHB) patients starting the antiviral nucleoside analogue, Tenofovir alafenamide (TAF).
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
15 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE216314
ID:
200216314
16.

Sustained Activation of Non-canonical NF-kB Signalling Drives Glycolytic Reprogramming in Doxorubicin-resistant DLBCL

(Submitter supplied) RNA-seq analysis of doxorubicin-sensitive and doxorubicin-resistant cells before and after doxorubicin exposure, and acquired-resistant compared to parental sensitive cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
30 Samples
Download data
Series
Accession:
GSE215900
ID:
200215900
17.

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease

(Submitter supplied) Alzheimer's disease (AD) is one of the neurodegenerative diseases and characterized by the appearance and accumulation of amyloid-β (Aβ) aggregates and phosphorylated tau with aging. We performed scRNAseq of immene cells in the brain from WT and AD mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data
Series
Accession:
GSE214747
ID:
200214747
18.

Gene expression profiling analysis of RNA-seq data for colorectal cancer organoids and spontaneous metastases mouse models

(Submitter supplied) We performed RNA-sequencing to investigate the gene expression profiles of colorectal cancer patient-derived organoids (PDO) and PDO-initiated spontaenous metastases mouse models
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
70 Samples
Download data: TXT
Series
Accession:
GSE213896
ID:
200213896
19.

RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

(Submitter supplied) NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis in the liver and adipose tissues by using tissue-specific HuR knockout mice. However, the underlying mechanism by which hepatocyte-specific HuR regulates hepatic lipid metabolism under metabolic stress remains unclear and is the focus of this study.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
4 Samples
Download data: TXT
Series
Accession:
GSE213215
ID:
200213215
20.

The effect of extreme hyperglycemia on the expression program of the human beta cell line EndoC-betaH2

(Submitter supplied) Our in vivo Insulin-rtTA;TET-DTA mouse model of severe hyperglycemia revealed that proloned exposure to very high glucose levels inhibits cell cycle entry and progression of pancreatic beta cells. To investigate the molecular mechanisms responsible for this observation and the relevance to human beta cells, we performed an in vitro experiment on EndoC-betaH2 mimiking the in vivo conditions and subjected them to RNAseq analysis.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: TSV
Series
Accession:
GSE212749
ID:
200212749
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