txid6239[orgn] AND "strain N2-Bristol"[All Fields] - GEO DataSets

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Select item 2002609381.

An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress miRNAs in a longevity model and an alg-1 overexpression model.

(Submitter supplied) Cellular response to redox imbalance is crucial for organismal health. microRNAs are implicated in stress responses. ALG-1, the C. elegans ortholog of human AGO2, plays an essential role in microRNA processing and function. Here we investigated the mechanisms governing ALG-1 expression in C. elegans and the players controlling lifespan and stress resistance downstream of ALG-1. We found that upregulated ALG-1 is a shared feature in conditions linked to increased longevity (e.g., germline-deficient glp-1 mutants). more...

Organism:: Caenorhabditis elegans

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18245
4 Samples

Download data: CSV

Series

Accession:: GSE260938

ID:: 200260938

PubMed Full text in PMC Similar studies

Select item 2002395722.

The CRTC-1 transcriptional domain is required for COMPASS complex mediated longevity in C. elegans

(Submitter supplied) Loss of function during ageing is accompanied by transcriptional drift, altering gene expression and contributing to a variety of age-related diseases. CREB-regulated transcriptional coactivators (CRTCs) have emerged as key regulators of gene expression that might be targeted to promote longevity. Here, we define the role of the Caenorhabditis elegans CRTC-1 in the epigenetic regulation of longevity. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26672
16 Samples

Download data: XLSX

Series

Accession:: GSE239572

ID:: 200239572

Select item 2002370603.

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

(Submitter supplied) mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nutrients are abundant. Ubiquitous inhibition of mTORC1 extends lifespan in multiple organisms but also disrupts several anabolic processes resulting in stunted growth, slowed development, reduced fertility, and disrupted metabolism. However, it is unclear if these pleotropic effects of mTORC1 inhibition can be uncoupled from longevity. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26672
24 Samples

Download data: XLSX

Series

Accession:: GSE237060

ID:: 200237060

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Select item 2002015994.

Expression data from C. elegans harboring type 1-like and type 2-like calreticulin mutations of MPN patients

(Submitter supplied) There is growing evidence that Ph-negative myeloproliferative neoplasms (MPNs) are blood cancers in which multiple molecular mechanisms are significantly disturbed. Since their discovery in 2016, CALR (calreticulin) type 1 and type 2 driver mutations have been demonstrated to trigger pathogenic mechanisms apart from the well-documented activation of JAK2/MPL-related pathways affecting these diseases. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL19230
10 Samples

Download data: CEL, CHP

Series

Accession:: GSE201599

ID:: 200201599

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002003835.

Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans

(Submitter supplied) RNA-seq performed for studying transcriptomic changesmodulated by neuronal HLH-30 during heat stress

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
24 Samples

Download data: TXT

Series

Accession:: GSE200383

ID:: 200200383

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Select item 2001840866.

Complete transcriptome of bir-2 knockdown C. elegans nematodes with and without exposure to pathogenic bacteria Enterococcus faecalis.

(Submitter supplied) Purpose: The goals of this study are to examine the role of C. elegans gene bir-2 in innate immunity. The method is to compare differences in gene expression of transcriptomes of C. elegans in the presence and absence of a bir-2 knockdown and with and without pathogenic bacteria. Results: We mapped about 4 million sequence paired-end reads of 251 nucleotide length for each of the 16 samples, trimmed the reads with Trimmomatic (v.0.38), mapped to the WBGene C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
16 Samples

Download data: CSV

Series

Accession:: GSE184086

ID:: 200184086

SRA Run Selector

Select item 2001781727.

Early-life starvation affects phosphatidylcholine metabolism and eicosanoid signaling in adults to cause pathology

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL22765 GPL26672
16 Samples

Download data

Series

Accession:: GSE178172

ID:: 200178172

Select item 2001781718.

mRNA-seq analysis of early adult C. elegans fatty acid synthesis mutant following extended L1 arrest

(Submitter supplied) Early-life malnutrition increases adult disease risk in humans, but the causal changes in gene regulation, signaling, and metabolism are unclear. In the roundworm Caenorhabditis elegans, early-life starvation causes well-fed larvae to develop germline tumors and other gonad abnormalities as adults. Furthermore, reduced insulin/IGF signaling (IIS) during larval development suppresses these starvation-induced abnormalities. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26672
4 Samples

Download data: XLSX

Series

Accession:: GSE178171

ID:: 200178171

SRA Run Selector

Select item 2001781709.

mRNA-seq analysis of early adult C. elegans following extended L1 arrest with reduced insulin/insulin-like signaling

(Submitter supplied) We characterized the effects of early-life starvation and reduced insulin/insulin-like signaling (IIS) during larval development on adult gene expression using mRNA-seq of whole worms. In our two-factor design, 'starved' worms were cultured without food (E. coli) in L1 arrest for eight days, and 'control' worms were starved overnight for synchronization. Both populations of worms were fed ad libitum with either empty vector (EV; negative control) or daf-2/InsR RNAi food (reduced IIS). more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
12 Samples

Download data: CSV

Series

Accession:: GSE178170

ID:: 200178170

SRA Run Selector

Select item 20019741210.

Transcellular chaperone signaling is an intercellular stress-response that is distinct from the HSF-1 mediated HSR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing

Platform:: GPL18245
19 Samples

Download data: XLSX

Series

Accession:: GSE197412

ID:: 200197412

Select item 20019741011.

Transcellular chaperone signaling is an intercellular stress-response that is distinct from the HSF-1 mediated HSR [RNA-seq]

(Submitter supplied) The goal of this RNA-Seq analysis was to identify genes differentially expressed in a C. elegans strain expressing a neuron-specific or gut-specific hsp-90 hairpin RNAi construct compared to control animals of the same genetic background (strain AM994). Tissue-specific expression of an hsp-90 hairpin RNAi construct knocks down hsp-90 in a tissue-specific manner and induces transcellular chaperone signalling that enhances organismal proteostasis. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
12 Samples

Download data: TXT

Series

Accession:: GSE197410

ID:: 200197410

Select item 20018147012.

Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [RNA-seq]

(Submitter supplied) RNA-seq perofrmed for studying transcriptomic changes induced by RNAi-mediated silencing of gene encoding nuclear export receptor XPO-1 in C. elegans nematodes.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
7 Samples

Download data: TXT

Series

Accession:: GSE181470

ID:: 200181470

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018146913.

Exportin 1 modulates lifespan by regulating nucleolar 1 dynamics via the autophagy protein LGG-1/GABARAP [polysome RNA]

(Submitter supplied) RNA-seq perofrmed for studying changes in total, monosome, and polysome-associated mRNA induced by RNAi-mediated silencing of gene encoding nuclear export receptor XPO-1 in C. elegans nematodes.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22765
11 Samples

Download data: CSV, TXT

Series

Accession:: GSE181469

ID:: 200181469

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Select item 20019254014.

Large scale transposon co-option in the Caenorhabditis germline regulatory network

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis briggsae; Caenorhabditis elegans

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other

Platforms:: GPL31139 GPL18730
14 Samples

Download data: BW

Series

Accession:: GSE192540

ID:: 200192540

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Select item 20019253815.

Large scale transposon co-option in the Caenorhabditis germline regulatory network [RNA-Seq]

(Submitter supplied) The movement of repetitive elements in the germline creates widespread genomic alterations and pressure for resolution. Here we show that the Caenorhabditis clade took advantage of two transposon expansions by integrating hundreds of elements into its germline transcriptional network. We find that about one-third of C. elegans germline-specific promoters have been co-opted from CERP2 and CELE2 MITE elements and are regulated by HIM-17, a THAP domain-containing transcription factor related to a transposase. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18730
4 Samples

Download data: BW

Series

Accession:: GSE192538

ID:: 200192538

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Select item 20019253516.

Large scale transposon co-option in the Caenorhabditis germline regulatory network [ChIP-Seq]

Organism:: Caenorhabditis elegans

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18730
2 Samples

Download data: BW

Series

Accession:: GSE192535

ID:: 200192535

PubMed Full text in PMC Similar studies

Select item 20012392117.

Developmental arrest in response to reduced protein synthesis in C. elegans

(Submitter supplied) Reducing overall biosynthetic capacity is one avenue for increasing health and lifespan; however, animals must be post-developmental in order to reap these benefits. When protein synthesis is reduced in newly hatched C. elegans, worms enter a temporary arrest state that promotes stress resistance and increases lipid stores. In order to determine the genetic underpinnings to this developmental arrest, we used RNA-seq to determine the transcriptional profile of animals arrested for 48hrs and 120hrs as L2 animals (via egl-45/EIF3A and rps-11/RPS11 RNAi) versus 24hr Control RNAi non-arrested animals. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
15 Samples

Download data: TXT, XLSX

Series

Accession:: GSE123921

ID:: 200123921

SRA Run Selector

Select item 20016892518.

A structural role for histone methyltransferase MET-2 represses transcription independent of H3K9me catalysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18245
47 Samples

Download data

Series

Accession:: GSE168925

ID:: 200168925

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Select item 20016892419.

A structural role for histone methyltransferase MET-2 represses transcription independent of H3K9me catalysis [RNA-seq]

(Submitter supplied) Packaging genomic regions into silenced heterochromatin is critical to maintain organismal viability and tissue identity. Methylation of histone H3 on lysine 9 (H3K9me) marks heterochromatin. Here we show that in addition to catalyzing H3K9me, the C. elegans histone methyltransferase MET-2 (SETDB1-like) has a second non-catalytic function that can itself contribute to gene repression. We find that subnuclear concentrates, or foci, of MET-2 correlate with efficient HMT activity, yet foci composed of catalytic-deficient MET-2 are also able to mediate transcriptional silencing. more...