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Items: 1 to 20 of 119196

1.

The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance

(Submitter supplied) The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation have been extensively investigated, the role of post-transcriptional control is still poorly understood. Here we show that the nuclear activity of the RNA-binding protein Second Mitotic Wave Missing (Swm) is critical for Drosophila melanogaster intestinal stem cells (ISCs) and their daughter cells, enteroblasts (EBs), to maintain their progenitor cell properties and function. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
9 Samples
Download data: CSV
Series
Accession:
GSE206632
ID:
200206632
2.

Genome-wide identification of long noncoding RNA and their potential interactors in ISWI mutants

(Submitter supplied) Long non-coding RNA (lncRNA) refers to non-coding RNA transcripts with a length of more than 200 nt. They regulate the expression level of target genes. However, the role of lncRNA in chromatin remodeling needs to be further explored. In this study, we used ISWI mutants (ISWI is a chromatin remodeling factor in Drosophila) to explore the function of lncRNA. Based on the transcriptome of ISWI mutant Drosophila, we analyzed the transcripts and conducted differential expression analysis. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL25244
12 Samples
Download data: TXT
Series
Accession:
GSE201291
ID:
200201291
3.

IRdb: an insect resistance database

(Submitter supplied) Pesticides are widely used to protect growth of crops and prevent the spread of diseases. However, more and more pest insects have developed resistance to chemical pesticides along with the long-term application of the pesticides. It is very important to explore the molecular mechanisms of insecticide resistance not only for reversing the resistance in insects, but also for finding out new function targets of the insecticides. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL26560
12 Samples
Download data: CSV
Series
Accession:
GSE206463
ID:
200206463
4.

Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster

(Submitter supplied) Maternal gene products supplied to the egg during oogenesis drive the earliest events of development in all metazoans. After the initial stages of embryogenesis, maternal transcripts are degraded as zygotic transcription is activated; this is known as the maternal to zygotic transition (MZT). Altering the abundances of maternally deposited factors in the laboratory can have a dramatic effect on development, adult phenotypes and ultimately fitness. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
48 Samples
Download data: TXT
Series
Accession:
GSE195496
ID:
200195496
5.

A Drosophila proto-oncogene homolog controls aggression via aminergic neurons

(Submitter supplied) Modulation of action choices according to the environmental context is crucial for animal survival and reproductive success1. Aggression, despite its general importance as a social behavior2, can become detrimental if uncontrolled3,4. However, the genetic and neural basis for aggression control through active suppression remains largely unknown. Here we found nvy, a Drosophila homolog of vertebrate myeloid translocation gene (MTG)5 involved in transcriptional regulation6-8, suppresses aggression through a specific subset of neurons. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
212 Samples
Download data: TXT
Series
Accession:
GSE148630
ID:
200148630
6.

Oo-site: A dashboard to visualize gene expression during Drosophila oogenesis reveals meiotic entry is regulated post-transcriptionally

(Submitter supplied) Determining how stem cell differentiation is controlled has important implications for understanding the etiology of degenerative disease and designing regenerative therapies. In vivo analyses of stem cell model systems have revealed regulatory paradigms for stem cell self-renewal and differentiation. The germarium of the female Drosophila gonad, which houses both germline and somatic stem cells, is one such model system. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
4 Samples
Download data: TAB
Series
Accession:
GSE195893
ID:
200195893
7.

Genome-wide maps of R-loops in Drosophila embryogenesis and cultured cells

(Submitter supplied) We report the genome localization of R-loops in early and late-stage embryos relative to Drosophila cultured cells. We demonstrate that proper absolute R-loop levels chage during embryogenesis and that resolution of R-loops is critical for embryonic development. R-loop mapping by strand-specific DRIP-seq revealed that R-loop localization is plastic across development, both in the genes which form R-loops and where they localize relative to gene bodies. more...
Organism:
Drosophila melanogaster
Type:
Other
Platform:
GPL25244
15 Samples
Download data: BED
Series
Accession:
GSE185403
ID:
200185403
8.

Next Generation Sequencing-based Quantitative Analysis of female whole body transcriptomes from w1118 (control) and foxo mutant flies exposed to normoxia or hypoxia for 16 hrs

(Submitter supplied) Purpose: The goal of this RNA-Seq is to analyze the whole-body transcriptomes from normoxia vs hypoxia exposed flies to identify differentially expressed genes and to identify which differentially gene expression changes require the FOXO transcription factor Abstract from associated manuscript: When exposed to low oxygen or hypoxia, animals must alter their metabolism and physiology to ensure proper cell-, tissue- and whole-body level adaptations to their hypoxic environment. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
15 Samples
Download data: XLSX
Series
Accession:
GSE206206
ID:
200206206
9.

Locomotor ability and brain gene expression in Drosophila melanogaster exhibit non-monotonic dose-response to HFPO-DA

(Submitter supplied) Per- and polyfluoroalkyl substances (PFAS) are persistent pollutants known for their bio-accumulative properties and prevalence in water supplies and household products. Although legacy PFAS, such as perfluorooctanoic acid, are phased out in the U.S. due to public health concerns, a PFAS variant hexafluoropropylene oxide-dimer acid (HFPO-DA) is an emerging replacement. HFPO-DA is a potential neurotoxicant that has been shown to cause dopaminergic neurodegeneration. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30203
74 Samples
Download data: CSV
Series
Accession:
GSE206119
ID:
200206119
10.

Precocious expression of Zelda does not initiate early zygotic genome activation

(Submitter supplied) During the first stages of development, the fertilized germ cells rapidly transition to totipotency. Maternally deposited mRNAs encode the proteins necessary for reprogramming the transcriptionally quiescent zygotic genome during this maternal-to-zygotic transition (MZT). The transcription factor Zelda is essential for this reprogramming in the Drosophila embryo. Zelda is necessary for transcriptional activation of the zygotic genome, and the absence of Zelda leads to embryonic lethality during the MZT. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
62 Samples
Download data: TXT
Series
Accession:
GSE197582
ID:
200197582
11.

PolyA+ RNA-Seq profiling of Drosophila melanogaster late third instar larval ovary, testis and sex transformed gonads as a result of tra and dsx perturbation.

(Submitter supplied) We designed this experiment to investigate the transcriptional changes in gonads as a result of sex transformation. Here we performed transcriptional profiling of the ovary transformed into testis from the tra loss of function (XX_tra_lof), testis transformed into ovary from the tra gain of function (XY_tra_gof) and ovary transformed into testis in dsxM gain of function (XX_DsxM_gof/lof) Drosophila melanogaster third instar larvae in biological quadruplicates. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17275
20 Samples
Download data: TXT
Series
Accession:
GSE205406
ID:
200205406
12.

Shared enhancer gene regulatory networks between wound and oncogenic programs [scRNA]

(Submitter supplied) Wound response programs are often activated during neoplastic growth in tumors. In both systems, cells respond to acute stress and balance the activation of multiple programs including apoptosis, proliferation, and cell migration. Central to this response are the JNK/MAPK and JAK/STAT signaling pathways. Yet, to what extent these signaling cascades interact at the cis-regulatory level, and how they orchestrate different phenotypic responses is still unclear. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL25244 GPL21306
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE205399
ID:
200205399
13.

Shared enhancer gene regulatory networks between wound and oncogenic programs [Multiome]

(Submitter supplied) Wound response programs are often activated during neoplastic growth in tumors. In both systems, cells respond to acute stress and balance the activation of multiple programs including apoptosis, proliferation, and cell migration. Central to this response are the JNK/MAPK and JAK/STAT signaling pathways. Yet, to what extent these signaling cascades interact at the cis-regulatory level, and how they orchestrate different phenotypic responses is still unclear. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25244
6 Samples
Download data: BED, MTX, TSV
Series
Accession:
GSE205387
ID:
200205387
14.

Shared enhancer gene regulatory networks between wound and oncogenic programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL25244 GPL21306
9 Samples
Download data: MTX, TSV
Series
Accession:
GSE205401
ID:
200205401
15.

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
45 Samples
Download data
Series
Accession:
GSE183816
ID:
200183816
16.

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

(Submitter supplied) RNA-binding proteins and messenger RNAs assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The dysregulation of RNA-protein condensation disturbs synaptic plasticity and neuron survival, and has been widely associated with human neurological disease. Neuronal granules are thought to condense around particular proteins that dictate the identity and composition of each granule type. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
18 Samples
Download data: TSV, XLSX
Series
Accession:
GSE183815
ID:
200183815
17.

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

(Submitter supplied) RNA-binding proteins and messenger RNAs assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The dysregulation of RNA-protein condensation disturbs synaptic plasticity and neuron survival, and has been widely associated with human neurological disease. Neuronal granules are thought to condense around particular proteins that dictate the identity and composition of each granule type. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
3 Samples
Download data: TXT
Series
Accession:
GSE183814
ID:
200183814
18.

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

(Submitter supplied) RNA-binding proteins and messenger RNAs assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The dysregulation of RNA-protein condensation disturbs synaptic plasticity and neuron survival, and has been widely associated with human neurological disease. Neuronal granules are thought to condense around particular proteins that dictate the identity and composition of each granule type. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
4 Samples
Download data: TXT
Series
Accession:
GSE183813
ID:
200183813
19.

The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

(Submitter supplied) RNA-binding proteins and messenger RNAs assemble into ribonucleoprotein granules that regulate mRNA trafficking, local translation, and turnover. The dysregulation of RNA-protein condensation disturbs synaptic plasticity and neuron survival, and has been widely associated with human neurological disease. Neuronal granules are thought to condense around particular proteins that dictate the identity and composition of each granule type. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
20 Samples
Download data: TSV, TXT
Series
Accession:
GSE183812
ID:
200183812
20.

Comparative interactome analysis of the PRE DNA-binding factors: purification of the Combgap, Zeste, Psq, and Adf1 associated proteins

(Submitter supplied) To gain an insight into the PRE DNA-binding protein regulatory network, here, using immunoaffinity purification coupled to the high throughput mass spectrometry, we isolated factors associated with the Combgap, Psq, Zeste and Adf1 PRE DNA-binding proteins. We show that Combgap and Zeste are more tightly associated with the Polycomb repressive complex 1 (PRC1), while Psq interacts strongly with the TrxG proteins, including the BAP SWI/SNF complex. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25244
9 Samples
Download data: BIGWIG
Series
Accession:
GSE200213
ID:
200200213
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