Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 1389730

1.

Anabolic resistance of skeletal muscle in cancer cachexia is caused by impaired IGF1 expression to mechanical loading

(Submitter supplied) Cachexia is a systemic metabolic syndrome characterized by loss of fat and skeletal muscle mass in chronic wasting diseases such as cancer. The regulation of cellular protein synthesis in response to workload in skeletal muscle is generally blunted in cancer cachexia; however, the precise molecular regulation is largely unknown. In this study, to examine the molecular mechanism of skeletal muscle protein metabolism in cancer cachexia, we analyzed comprehensive gene expression in skeletal muscle using microarrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
2 Samples
Download data: TXT
Series
Accession:
GSE185934
ID:
200185934
2.

SFPQ-ABL1 and BCR-ABL1 utilise different signalling networks to drive B-cell acute lymphoblastic leukaemia

(Submitter supplied) Purpose: We identified a rare instance of the SFPQ-ABL1 in a child with Ph-like ALL. The overall purpose of this study was to compare the structure and function of the SFPQ-ABL1 fusion to the well characterised BCR-ABL1 fusion. We used phosphoproteomics, transcriptomics and functional assays to determine the transforming capacity, subcellular localisation, and signalling networks of these two fusions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
12 Samples
Download data: TXT
Series
Accession:
GSE185860
ID:
200185860
3.

Cardiomyocyte TLR4 regulates autophagy through TRAF6-mediated TFEB ubiquitination in sepsis-associated cardiac dysfunction

(Submitter supplied) Sepsis-associated cardiac dysfunction (SACD) is the predominant cause of death in sepsis patients with undefined mechanism of inflammation-autophagy interaction to date. Herein, time-course analysis of cardiac autophagy was conducted in a mouse model of SCAD. An in vitro model established by Lipopolysaccharide-induced macrophage conditioned media stimulation on cardiomyocytes was further investigated for molecular insights. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: TXT
Series
Accession:
GSE185754
ID:
200185754
4.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data
Series
Accession:
GSE185724
ID:
200185724
5.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [LY]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the T cell developmental landscape in Naked mole-rats and showed
Organism:
Heterocephalus glaber; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: RDATA
Series
Accession:
GSE185721
ID:
200185721
6.

Single-cell RNA-Sequencing maps the hematopoietic landscape in naked mole-rats [BM]

(Submitter supplied) Naked mole-rats are a mammalian model organism of exceptional longevity. We mapped the hematopoietic hierarchy and used functional characterizations to define a purified stem and progenitor cell (HSPC) compartment similar to mouse LIN-/Sca-1+/Kit+ HSPCs or human LIN-/CD34+/CD38lo HSPCs.
Organism:
Mus musculus; Heterocephalus glaber
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: RDATA
Series
Accession:
GSE185720
ID:
200185720
7.

Genome-wide Spatial Expression Profiling in Formalin-fixed Tissues

(Submitter supplied) Method to perform spatial analysis of mRNA in FFPE and PFA fixed tissue sections using spatially barcoded slides and based on oligo(dT) mRNA capture.
Organism:
Homo sapiens; Mus musculus
Type:
Other
Platforms:
GPL30172 GPL30173
14 Samples
Download data
Series
Accession:
GSE185715
ID:
200185715
8.

Microglial-expressed Apoe does not modulate plaque pathogenesis

(Submitter supplied) This dataset allows for the exploration of the effect of microglial-expressed Apoe knockout in a 5xFAD Alzheimer's Disease model.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
45 Samples
Download data: XLS
Series
Accession:
GSE185622
ID:
200185622
9.

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA expression of STAT3 deficiency skin

(Submitter supplied) Dominant-negative mutations of signal transducer and activator of transcription 3 (STAT3) signaling which controls epithelial proliferation in various tissues, leads to atopic dermatitis (AD) in hyper IgE syndrome (HIES). We found that the STAT3 signaling in keratinocytes is required to maintain skin homeostasis through this transcriptome analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
48 Samples
Download data
Series
Accession:
GSE185585
ID:
200185585
10.

Single-cell Architecture and Functional Requirement of Alternative Splicing during Hematopoietic Stem Cell Emergence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
47 Samples
Download data: TXT
Series
Accession:
GSE185555
ID:
200185555
11.

Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain: RNA sequencing data

(Submitter supplied) We describe the effects of cocaine and methamphetamine treatment on astrocytic expression of the corticotropin releasing factor 2 receptor and the excitatory amino acid transporter 1 in the ventral midbrain. The RNA-sequencing data confirms the expression of CRF2R on astrocytes using the Aldh1l1-NuTRAP model. This allowed for astrocyte mRNA isolation and characterization, confirming CRF2R expression on ventral midbrain astrocytes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
10 Samples
Download data: TXT
Series
Accession:
GSE184497
ID:
200184497
12.

Aging reduces liver resiliency by dysregulating Hedgehog signaling

(Submitter supplied) Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency (i.e., the ability to recover from injury) and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with critical mitogenic and morphogenic functions during development. Recent studies indicate that Hedgehog regulates metabolic homeostasis in adult liver. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
18 Samples
Download data
Series
Accession:
GSE181761
ID:
200181761
13.

Dual checkpoint blockade of CD47 and PD-L1 using a novel affinity-tuned bispecific antibody maximizes anti-tumor immunity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platform:
GPL30261
10 Samples
Download data: XLSX
Series
Accession:
GSE180297
ID:
200180297
14.

Exercise prevents substrate overload of liver mitochondria by modification of the compensatory responses during chronic overnutrition

(Submitter supplied) Exercise training is a potent treatment of NAFLD and hepatic insulin resistance. Here we provide molecular information about the hepatic mitochondrial metabolism in mice when chronic overnutrition (high-energy diet (HED) for 6 weeks) is combined with exercise training. Training reduced the hepatic triacylglycerol content, fasting insulin, and reversed glucose intolerance. Training modified the hepatic mitochondrial proteome with a decrease in enzymes related to pyruvate metabolism and entry of acetyl-CoA into the TCA cycle. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL23038
29 Samples
Download data: CEL
Series
Accession:
GSE167046
ID:
200167046
15.

Differentiating mouse ESC towards gonadal progenitors cells

(Submitter supplied) We developed a gradual differentiation protocol to differentiate mESC towards the EpiSC lineage, followed by early mesoderm cells. These were later differentiated to intermediate mesoderm and we found a condition (IM3) that best generates early gonadal progenitor cells which are normally present at the bipotential gonad at E11.5. Forced expression of 2 transcription factors: Nr5A1 (SF1) and Dmrt1 induced a specific-Sertoli marker (TESCO-CFP) and the cells started to self-aggregate and form tubule-like structures, highly resembling the testis cords. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
27 Samples
Download data: TXT
Series
Accession:
GSE165133
ID:
200165133
16.

ERK, differentially regulated by costimulation molecules, represses Zfp831, a critical regulator in T follicular helper cell differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data
Series
Accession:
GSE163808
ID:
200163808
17.

Perivascular niche cells sense thrombocytopenia and activate platelet-biased HSCs in an IL-1 dependent manner

(Submitter supplied) RNA sequencing analysis of stromal cells, haematopoietic stem cells and megakaryocytes from mice in homeostasis and after platelet depletion
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
66 Samples
Download data: TXT
Series
Accession:
GSE121249
ID:
200121249
18.

Molecular Pathways are influenced by Progranulin in a neuronal cell model

(Submitter supplied) Gene expression microarrays were used to identify how the mRNA phenotype of NSC-34 cells responds to PGRN expression levels. PGRN expression correlated well with molecular phenotypes that included mRNA pathways associated with the regulation of the cytoskeleton Gene expression profile was determined using Illumina Mouse Whole-Genome Expression BeadChips (MouseWG-6 v2.0
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE185877
ID:
200185877
19.

Chip-seq analyses of PPARγ bonded DNA fragments

(Submitter supplied) Chip-seq analyses of PPARγ bonded DNA fragments revealed that Arid5b, Rorb, Pank2 and Htr2c are the downstream target genes for PPARγ regulated adipogenesis in fetal preadipocyte.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: TXT
Series
Accession:
GSE185779
ID:
200185779
20.

Transcriptome-wide N6-methyladenine profiling in low input multiplex samples by a kit-free multi-barcode method

(Submitter supplied) N6-methyladnine, which is the most abundant post-transcriptional RNA modification in eukaryotic mRNA, has been proved to be essential in various biological processes and related to numerous diseases. Transcriptome-wide m6A profiling by next generation sequencing is widely used to explore the distributions as well as quantity of m6A modifications. As traditional m6A-seq demands large amount of starting RNA which limited its application to clinical samples, we present a strategy of low input multi-barcode m6A-seq (SLIM-m6A-seq) to realize simplified m6A profiling of mixed clinical samples. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL20795 GPL21273
10 Samples
Download data: CSV, XLSX
Series
Accession:
GSE185749
ID:
200185749
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=txid862507[Organism]|query=1|qty=374|blobid=MCID_616b258e45cdce07892a4972|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center