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Items: 1 to 20 of 4886945

1.

Ssc-miR-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene

(Submitter supplied) The TYRP1 gene can affect melanogenesis in melanocytes of the Xiang pigs, and ssc-miR-221-3p targets the TYRP1 gene to affect melanogenesis in melanocytes of the Xiang pigs.
Organism:
Sus scrofa
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL22918
6 Samples
Download data: TXT
Series
Accession:
GSE218870
ID:
200218870
2.

Safeguarding genome integrity during gene-editing therapy of age-related macular degeneration

(Submitter supplied) Ensuring genome safety during gene editing is crucial for clinical translation of the high-efficient CRISPR-Cas9 toolbox. Therefore, the undesired events including chromosomal translocations, vector integrations, and large deletions arising during therapeutic gene editing remain to be adequately addressed or tackled in vivo. Here, we apply CRISPR-Cas9TX in comparison to CRISPR-Cas9 to target Vegfa for the treatment of age-related macular degeneration (AMD) disease in a mouse model. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
117 Samples
Download data
Series
Accession:
GSE218818
ID:
200218818
3.

Vitamin D3 and deconvoluting a rash

(Submitter supplied) To establish an expression profile of Nitrogen Mustard (NM) exposure-induced genes in healthy human skin and effect of VitD intervention. We further characterized a distinct intervention-independent response type in half of subjects after the 2nd NM exposure
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
110 Samples
Download data: TXT
Series
Accession:
GSE218810
ID:
200218810
4.

Missense mutation of c.635T>C in CAPN3 impairs muscle in-jury repair in a Limb-Girdel Muscular Dystropy Model

(Submitter supplied) Limb-girdle muscular dystrophies (LGMD) is a group of muscle diseases characterized by pro-gressive muscle weakness and muscular atrophy of proximal muscles. Limb-girdle muscular dystrophy recessive 1 (LGMDR1), previously known as LGMD2A, is a specific LGMD caused by a gene mutation encoding the calcium-dependent neutral cysteine protease calpain-3 (CAPN3). In our previous study, a novel compound heterozygous mutation, c.635T>C causing missense mu-tation of p.Leu212Pro, was identified in LGMDR1 patients. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: XLS
Series
Accession:
GSE218769
ID:
200218769
5.

Metabolism of Eriocitrin in the Gut and its Regulation on Gut Microbiota in Mice

(Submitter supplied) Eriocitrin, found in lemon fruit, has shown a wide range of biological properties. Herein, to evaluate the intestinal metabolic profile of eriocitrin in colon, the flavonoids in mice colon contents were identified by ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS), and a total of 136 flavonoids were found, including eriocitrin and its six metabolites (eriodictyol, homoeriodictyol, hesperetin, eriodictyol-3'-O-glucoside, hesperetin-7-O-glucoside and eriodictyol-7-O-(6''-O-galloyl) glucoside). more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL24247
12 Samples
Download data: XLSX
Series
Accession:
GSE218729
ID:
200218729
6.

Porphyromonas gingivalis outer membrane vesicles promote apoptosis via msRNA-regulated DNA methylation in periodontitis

(Submitter supplied) The outer membrane vesicles (OMVs) produced by Porphyromonas gingivalis (P. gingivalis) contain a variety of bioactive molecules that may be involved in the progression of periodontitis. However, the participation of P. gingivalis OMVs in the development of periodontitis has not been elucidated. Here we isolated P. gingivalis OMVs and confirmed their participation in periodontitis both in vivo and in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: TXT
Series
Accession:
GSE218606
ID:
200218606
7.

Gene expression profile at single cell level of tumor cells and immune cells from mouse SCLC tumors and preSC allograft samples.

(Submitter supplied) Small cell lung carcinoma (SCLC) is a lethal neuroendocrine type of lung cancer with limited therapeutic options. We used single cell RNA sequencing (scRNA-seq) to study SCLC tumogenesis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data
Series
Accession:
GSE218544
ID:
200218544
8.

Alterations in PTPN11 and other RAS-/MAP-Kinase pathway genes define ganglioglioma with adverse clinical outcome and atypic histopathological features

(Submitter supplied) Genome wide DNA methylation profiling of human low grade epilepsy associated brain tumor tissue. The Illumina Infinium 450K and 850K Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 450.000 and 850.000 CpGs in formalin-fixed paraffin-embedded surgical brain samples. Samples included 280 cases with various brain tumor diagnosis including low grade epilepsy associated tumors and non-epilepsy autopsy controls.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
86 Samples
Download data: TXT
Series
Accession:
GSE218542
ID:
200218542
9.

Altered gene expression in plasma of patients with pneumonia-induced sepsis compared to pneumonia without sepsis and healthy people

(Submitter supplied) To investigate the differentially expressed genes in the plasma of pneumonia-induced sepsis patients compared to pneumonia patients without sepsis and healthy people, we performed gene expression profiling analysis using data obtained from RNA-seq.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL24676
9 Samples
Download data: XLSX
Series
Accession:
GSE218494
ID:
200218494
10.

SCOPE-seq Analysis of Intra-operative Labeling Specificity of 5-ALA for Glioblastoma

(Submitter supplied) Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor, and surgical resection is a key part of the standard-of-care. In fluorescence-guided surgery (FGS), fluorophores are used to differentiate tumor tissue from surrounding normal brain. The heme synthesis pathway converts 5-aminolevulinic acid (5-ALA), a fluorogenic substrate, to the fluorophore protoporphyrin IX (PpIX). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data
Series
Accession:
GSE218331
ID:
200218331
11.

Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart

(Submitter supplied) Background: Organ fibrosis due to excessive production of extracellular matrix (ECM) by resident fibroblasts is estimated to contribute to >45% of deaths in the Western world, including those due to cardiovascular diseases such as heart failure (HF). Here, we screened for small molecule inhibitors with a common ability to suppress activation of fibroblasts across organ systems. Methods: High content imaging of cultured cardiac, pulmonary and renal fibroblasts was employed to identify non-toxic compounds that blocked induction of markers of activation in response to the profibrotic stimulus, TGF-β. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25947
16 Samples
Download data: XLSX
Series
Accession:
GSE217957
ID:
200217957
12.

Differential expression of microRNAs in adipose tissue with aging and caloric restriction

(Submitter supplied) To further analyze the effect of aging and caloric restriction in the microRNA expression, we have employed microarray expression profiling as a discovery platform to identify differentially expressed microRNAs in middle-aged animals and the impact of caloric restriction in the microRNA expression profile. Subcutaneous and visceral adipose tissue were extracted from 3 groups of mice: 3 month-old, 12 month-old fed ad libitum and 12 month-old fed with a caloric restricted diet. more...
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL30615
25 Samples
Download data
Series
Accession:
GSE217353
ID:
200217353
13.

Examination of Generational Impacts of Adolescent Chemotherapy: Ifosfamide and Potential for Epigenetic Transgenerational Inheritance

(Submitter supplied) The current study was designed to use a rodent model to determine if exposure to the chemotherapy drug ifosfamide during puberty can induce altered phenotypes and disease in the grand-offspring of exposed individuals through epigenetic transgenerational inheritance. Numerous toxicant exposures during critical developmental windows can have generational impacts through this non-genetic inheritance mechanism. more...
Organism:
Rattus norvegicus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL18694
34 Samples
Download data: CSV
Series
Accession:
GSE217141
ID:
200217141
14.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
10 Samples
Download data
Series
Accession:
GSE217139
ID:
200217139
15.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups III

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data
Series
Accession:
GSE217137
ID:
200217137
16.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups II

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data
Series
Accession:
GSE217136
ID:
200217136
17.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups I

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data
Series
Accession:
GSE217135
ID:
200217135
18.

Variable phenotypes and penetrance between and within different zebrafish transition zone mutants

(Submitter supplied) Meckel Syndrome, Nephronophthisis, Joubert Syndrome, and Bardet-Biedl Syndrome have mutations in proteins that localize to the ciliary transition zone (TZ). The phenotypically distinct syndromes suggest these TZ proteins have differing functions. However, mutations in a single TZ gene can result in multiple syndromes suggesting the phenotype is influenced by modifier genes. We performed a comprehensive analysis of ten zebrafish TZ mutants including mks1, tmem216, tmem67, rpgrip1l, cc2d2a, b9d2, cep290, tctn1, nphp1, and nphp4, as well as mutants in ift88 and ift172. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
26 Samples
Download data
Series
Accession:
GSE217001
ID:
200217001
19.

Samples from prospectively enrolled patients with histologically confirmed primary Head and Neck squamous cell carcinoma (HNSCC) were analyzed for miRNA profiling

(Submitter supplied) miRNA profiling in HNSCC, including 66 paired normal, peritumor and tumor tissues from the same patients, and additional 55 unpaired tumor tissues
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platforms:
GPL8227 GPL16770
253 Samples
Download data: TXT
Series
Accession:
GSE216630
ID:
200216630
20.

Chromatin immunoprecipitation and high-throughput sequencing (ChIP-seq) detection of histone H3 lysine 14 acetylation (H3K14ac) and KAT7 (HBO1) in E14.5 mouse neural stem and progenitor cells (NSPCs)

(Submitter supplied) Tissue specific deletion of the gene encoding the histone acetyltransferase KAT7 (HBO1) in the developing mouse central nervous system using cre-recombinase expression driven by regulatory sequences of the nestin locus (NesCre transgene) resulted in defective cerebral cortex development, a complete failure of neural stem cells to give rise to neurons and oligodendrocytes during in vitro differentiation and a failure to express the neuronal differentiation program. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
13 Samples
Download data
Series
Accession:
GSE216459
ID:
200216459
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