GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL33441 GPL30489

50 Samples

Download data: TXT

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue was collected at 0.9 term for bulk RNA Seq analysis

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30489

8 Samples

Download data: TXT

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis

Organism:

Papio anubis

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL33441

24 Samples

Download data: TXT

(Submitter supplied) To investigate the effects of maternal adiposity and leptin on fetal brain development, fetal hippocampal brain tissue and DNA was collected at 0.9 term for targeted EM-Seq analysis

Organism:

Papio anubis

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL30489

18 Samples

Download data: TXT

(Submitter supplied) To date, there are no efficacious translational solutions for end-stage urinary bladder dysfunction. Current surgical strategies including urinary diversion and bladder augmentation enterocystoplasty (BAE) utilize autologous intestinal segments (e.g. ileum) to increase bladder capacity to protect renal function. Considered the standard of care, BAE is fraught with numerous short- and long-term clinical complications. more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23487

28 Samples

Download data: TXT

(Submitter supplied) Increased levels of Fetal Hemoglobin reduce the severity of symptoms of patients with sickle cell disease and decrease the risk of death. An affordable, small molecule drug that stimulates HbF expression in vivo would be ideally suited to treat the large numbers of SCD patients that exist worldwide. Our previous work showed that administration of the LSD1 (KDM1A) inhibitor RN-1 to normal baboons increased Fetal Hemoglobin (HbF) and was tolerated over a prolonged treatment period. more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27009

6 Samples

Download data: XLSX

(Submitter supplied) Steady-state expression quantitative trait loci (eQTLs) explain only a fraction of disease-associated loci identified through genome-wide association studies (GWAS), while eQTLs involved in gene-by-environment (GxE) interactions have rarely been characterized in humans due to experimental challenges. Using a baboon model, we found hundreds of eQTLs that emerge in adipose, liver, and muscle after prolonged exposure to high dietary fat and cholesterol. more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL33248 GPL30489

588 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca fascicularis; Mus musculus; Murina leucogaster; Papio anubis; Ursus americanus; Petaurus breviceps; Castor canadensis; Peromyscus leucopus; Tamias sibiricus

Type:

Expression profiling by high throughput sequencing

9 related Platforms

90 Samples

Download data

(Submitter supplied) Lifespan varies both within and across species, but the general principles of its control are not understood. To identify transcriptomic signatures of mammalian longevity, we sequenced multiple organs of young adult mammals corresponding to 8 different species, including Canadian beaver, long-tailed macaque, greater tube-nosed bat, baboon, white-footed mouse, sugar glider, Siberian chipmunk and American black bear. more...

Organism:

Petaurus breviceps; Murina leucogaster; Castor canadensis; Macaca fascicularis; Papio anubis; Ursus americanus; Peromyscus leucopus; Tamias sibiricus

Type:

Expression profiling by high throughput sequencing

8 related Platforms

48 Samples

Download data: CSV

(Submitter supplied) Antineoplastic treatments for cancer and other non-malignant disorders can result in male long-term or permanent infertility by ablating spermatogonial stem cells (SSCs). Preserving the future fertility of prepubertal patients faced with this prospect cannot rely on sperm banking. SSC transplantation using testicular tissue harvested before sterilizing treatment is a promising approach for restoring fertility, but lack of exclusive biomarkers which can unequivocally identify prepubertal SSCs in any primate species limits the therapeutic potential. more...

Organism:

Macaca mulatta; Papio anubis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL30489 GPL21120 GPL27943

6 Samples

Download data: MTX, TSV

(Submitter supplied) The mucociliary airway epithelium lines the human airways and is the primary site of host-environmental interactions in the lung. Following virus infection, airway epithelial cells initiate an innate immune response to suppress virus replication. Therefore, defining the virus-host interactions of the mucociliary airway epithelium is critical for understanding the mechanisms that regulate virus infection, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL33218

8 Samples

Download data: TXT

(Submitter supplied) The development and progression of endometriotic lesions are poorly understood, but immune cell dysfunction and inflammation are closely associated with the pathophysiology of endometriosis. A lack of suitable 3D in vitro models permitting the study of interactions between cell types and the microenvironment is a contributing factor. To address this limitation, we developed endometriotic organoids (EO) to explore the role of epithelial-stromal interactions and model peritoneal cell invasion associated with lesion development (GSE202661). more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30489

7 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio anubis; Homo sapiens; Mus musculus; synthetic construct

Type:

Expression profiling by RT-PCR

Platforms:

GPL30487 GPL30488 GPL30486

99 Samples

Download data

(Submitter supplied) Oligodendrocytes were aspirated after electrophysiology recordings for qPCR analysis from cerebellum slices

Organism:

Papio anubis; synthetic construct; Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL30488

12 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:

GPL29629

102 Samples

Download data

(Submitter supplied) To investigate the extent of similarity in epigenetic programming among human, baboon and mouse PSCs, we examined genome-wide patterns of four chromatin modifications (H3K4me3, H3K9me3, H3K27me3, H3K27ac) and DNA methylation in baboon iPSC and ESCs. We show that baboon pluripotent cells (PSCs) recapitulate key molecular features of human PSCs with much greater accuracy than that found in PSCs from non-primate species. more...

Organism:

Papio anubis

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL29629

24 Samples

Download data: BW, NARROWPEAK

(Submitter supplied) To investigate the extent of similarity in epigenetic programming among human, baboon and mouse PSCs, we examined genome-wide patterns of four chromatin modifications (H3K4me3, H3K9me3, H3K27me3, H3K27ac) and DNA methylation in baboon iPSC and ESCs. We show that baboon pluripotent cells (PSCs) recapitulate key molecular features of human PSCs with much greater accuracy than that found in PSCs from non-primate species. more...

Organism:

Papio anubis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL29629

60 Samples

Download data: BROADPEAK, BW, NARROWPEAK

(Submitter supplied) To investigate the extent of similarity in epigenetic programming among human, baboon and mouse PSCs, we examined genome-wide patterns of four chromatin modifications (H3K4me3, H3K9me3, H3K27me3, H3K27ac) and DNA methylation in baboon iPSC and ESCs. We show that baboon pluripotent cells (PSCs) recapitulate key molecular features of human PSCs with much greater accuracy than that found in PSCs from non-primate species. more...

Organism:

Papio anubis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL29629

18 Samples

Download data: BW, TSV

(Submitter supplied) The advent of animal husbandry and hunting increased human exposure to zoonotic pathogens. To understand how a zoonotic disease influenced human evolution, we studied changes in human expression of anthrax toxin receptor 2 (ANTXR2), which encodes a cell surface protein necessary for Bacillus anthracis virulence toxins to cause anthrax disease. In immune cells, ANTXR2 was 8-fold down-regulated in all available human samples compared to non-human primates, indicating regulatory changes early in the evolution of modern humans. more...

Organism:

Papio anubis; Macaca mulatta

Type:

Other

Platforms:

GPL14954 GPL30489 GPL27943

12 Samples

Download data: HIC, SF, TXT

(Submitter supplied) We report the whole genome transcriptomic responses of ape species (human, common chimpanzee) and AAMs (rhesus macaque and olive baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ∼40% more genes than AAMs. more...

Organism:

Macaca mulatta; Pan troglodytes; Homo sapiens; Papio anubis

Type:

Expression profiling by high throughput sequencing

4 related Platforms

151 Samples

Download data: TXT