txid9604[Organism] - GEO DataSets

Search results

Items: 1 to 20 of 3883656

<< First< Prev

Page of 194183

Select item 2002638571.

Effects of a humanized ectopic niche (human ossicle or hOss) on human hematopoiesis

(Submitter supplied) Human hematopoiesis takes place in the bone marrow (BM) where a multitude of interactions regulate differentiation and preservation of hematopoietic stem/progenitor cells (HSPC). Well-studied in mouse models, human BM microenvironment still contain unexplored features. Development of immune-deficient mouse models have considerably improved our knowledge of the molecular and cellular regulation of human HSPC, but remain limited by the numerous non-cross-reactive signals provided by the mouse BM to human HSPC. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE263857

ID:: 200263857

Select item 2002635882.

Comprehensive transcriptomic profiling of glioblastoma patient-derived primary tumor cell lines using bulk RNA-sequencing

(Submitter supplied) Glioblastoma multiforme (GBM) is a highly aggressive primary brain cancer with significant transcriptomic heterogeneity among patients. Our study aims to contribute to the field of personalized medicine for GBM patients by providing comprehensive transcriptomic profiles of GBM patients (N = 45) who underwent concurrent chemoradiotherapy with temozolomide at Seoul National University Hospital. Additionally, we include transcriptomic profiles of normal brain tissue obtained from GBM patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
49 Samples

Download data: TXT

Series

Accession:: GSE263588

ID:: 200263588

Select item 2002635393.

ChIP-seq analysis of G3BP1 in KGN cells

(Submitter supplied) To investigate whether G3BP1 binds to telomeric DNA, we performed the ChIP-seq analysis of G3BP1 in KGN cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
2 Samples

Download data: BW

Series

Accession:: GSE263539

ID:: 200263539

Select item 2002635314.

Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression

(Submitter supplied) Age-related diseases pose great challenges to health care systems worldwide. During aging, endothelial senescence increases the risk for cardiovascular disease. Recently, it was described that Phosphatase 1 Nuclear Targeting Subunit (PNUTS) has a central role in cardiomyocyte aging and homeostasis. Here, we determined the role of PNUTS in endothelial cell aging. We confirmed that PNUTS is repressed in senescent endothelial cells (ECs). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: XLSX

Series

Accession:: GSE263531

ID:: 200263531

Select item 2002536505.

Biological Effects of Intraoperative Radiation Therapy (IORT): Histopathological Changes and Immunomodulation in Breast Cancer Patients

(Submitter supplied) Intraoperative radiation therapy (IORT) delivers a single accelerated radiation dose directly to the breast tumor bed. The synergistic effects of simultaneous surgery and radiation are poorly understood. We here explored the cellular and molecular changes induced by IORT in the tumor bed compared to no-IORT exposed breast tissues. Squamous metaplasia (SM) was identified in both cohorts; however, squamous metaplasia with atypia (SMwA) was only seen in IORT specimens (63.6%, p=0.004). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
37 Samples

Download data: CSV

Series

Accession:: GSE253650

ID:: 200253650

Select item 2002159016.

SPATAC-seq: split-pool ligation-based single cell ATAC-seq method

(Submitter supplied) To establish an ultra-high-throughput single cell chromatin accessibility profiling method that is cost-effective and widely accessible, we built on sci-ATAC-seq (Cusanovich, D. A. et al. Science. 2015; Amini, S. et al. Nature Genetics. 2014) and SPLIT-seq (Rosenberg, A. B. et al. Science. 2018) to design SPATAC-seq, which in situ label chromatin fragment in the same single cell through combinatorial barcoding. more...

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL25526 GPL26363
8 Samples

Download data: CSV, TSV

Series

Accession:: GSE215901

ID:: 200215901

Select item 2001721507.

Expression of miRNA in exosomes from transudative pleural effusion and tuberculous pleural effusions

(Submitter supplied) Pleural fibrosis is defined as an excessive deposition of extracellular matrix (ECM) that results in destruction of the normal pleural tissue architecture and compromised function. However there is currently no effective medication for pleural fibrosis. Understanding the detailed mechanisms of pleural fibrosis is an important unmet need which could lead to the identification of new targets for treatment of this condition. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE172150

ID:: 200172150

SRA Run Selector

Select item 2002638448.

Targeting metabolism to improve immunotherapy in GSNOR-deficient colorectal cancer

(Submitter supplied) Colorectal cancer (CRC) is the third most diagnosed type of cancer and the second leading cause of cancer death worldwide. Despite the increasing knowledge of CRC molecular biology and the development of new targeted therapies, its high heterogeneity hampers the efficacy of current treatments. Thus, there is a pressing need to identify new effective therapeutic targets and improve immune therapies for these patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
34 Samples

Download data: TXT

Series

Accession:: GSE263844

ID:: 200263844

Select item 2002636459.

Whole transcriptome sequencing for wild type and IRAIN over-expression K562 cells

(Submitter supplied) The development of tyrosine kinase inhibitors (TKIs) has revolutionarily increased the overall survival of patients with chronic myeloid leukemia (CML). However, drug resistance remains a major obstacle. Here, we demonstrated that a BCR-ABL1-independent long non-coding RNA, IRAIN, is constitutively expressed at low levels in CML, resulting in imatinib resistance. IRAIN knockdown decreased the sensitivity of CD34+ CML blasts and cell lines to imatinib, whereas IRAIN overexpression significantly increased sensitivity. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: XLSX

Series

Accession:: GSE263645

ID:: 200263645

Select item 20026356510.

Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress

(Submitter supplied) The maintenance of pancreatic islet architecture is crucial for proper β-cell function. We previously reported that disruption of human islet integrity could result in altered β-cell identity. Here we combine β-cell lineage tracing and single-cell transcriptomics to investigate the mechanisms underlying this process in primary human islet cells. Using drug-induced ER stress and cytoskeleton modification models, we demonstrate that altering the islet structure triggers an unfolding protein response that causes the downregulation of β-cell maturity genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data: CSV

Series

Accession:: GSE263565

ID:: 200263565

Select item 20026346211.

Transcriptome comparison of monocytes, activated CD4 T cells, and activated CD8 T cells in healthy human peripheral blood

(Submitter supplied) Molecular tether-mediated extracellular targeted protein degradation (ePTD) emerges as a promising drug modality. The existing strategies for ePTD have exploited several membrane degrader proteins. However, the current panel of ePTD degraders clearly needs to be expanded, as a given degrader may present tissue-dependent expression and activity. Based on screening of >50 receptors on endocytic rates and on their tissue distribution, we established a resource of potential endocytic carriers that may mediate effective ePTD. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: XLS

Series

Accession:: GSE263462

ID:: 200263462

Select item 20024366712.

Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities

(Submitter supplied) Activation-induced cytidine deaminase (AID) is a B cell-specific base editor required during class switch recombination and somatic hypermutation for B cell maturation and antibody diversification. However, it has also been implicated as a factor in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patients at-risk for certain types of blood cancers is critical in assessing disease severity and treatment options. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE243667

ID:: 200243667

Select item 20023152513.

DUSP6 inhibition overcomes Neuregulin/HER3-driven therapy resistance in HER2+ breast cancer [BT474]

(Submitter supplied) To investigate transcriptomic changes during development of resistance to lapatinib in a HER2+ breast cancer cell line We performed gene expression profiling analysis using data obtained from RNA-seq of 4 different stage of development of lapatinib resistance in a HER2+ breast cancer cell line

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TSV

Series

Accession:: GSE231525

ID:: 200231525

Select item 20023152414.

DUSP6 inhibition overcomes Neuregulin/HER3-driven therapy resistance in HER2+ breast cancer [MDA]

(Submitter supplied) To investigate transcriptomic changes regulated by DUSP6 in a HER2+ breast cancer cell line We performed gene expression profiling analysis using data obtained from RNA-seq of SCR vs DUSP6 KD MDA-MB-453 cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TSV

Series

Accession:: GSE231524

ID:: 200231524

Select item 20022830615.

Wnt signaling regulates chemokine production and cell migration of circulating human monocytes

(Submitter supplied) The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt signaling is closely associated with various pathological conditions, including inflammation and different types of cancer. Here, we show a new connection between the leukocyte inflammatory response and the Wnt signaling pathway. Specifically, we demonstrate that circulating human primary monocytes express distinct Wnt signaling components and are susceptible to stimulation by the classical Wnt ligand - Wnt-3a. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: XLSX

Series

Accession:: GSE228306

ID:: 200228306

Select item 20020357116.

m6a methylation drives IMP1 regulation during human neuronal differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other; Methylation profiling by high throughput sequencing

Platform:: GPL20301
48 Samples

Download data: BED, BEDGRAPH, TAB

Series

Accession:: GSE203571

ID:: 200203571

Select item 20020357017.

m6a methylation drives IMP1 regulation during human neuronal differentiation [miCLIP]

(Submitter supplied) Human neurodevelopment requires differentiating neurons to establish large networks of connections in a highly stereotyped manner. Neuronal differentiation in particular requires RNA-binding proteins to spatiotemporally regulate thousands of different mRNAs. Yet how these proteins precisely relate to neuronal development and coordinate the expression of functionally coherent genes in a cell type specific manner is only partially understood. more...