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Items: 1 to 20 of 2533192

1.

Transcriptomic and Epigenomic Profiles of CIC-knockout and IDH1 mutant cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL16791 GPL20795
116 Samples
Download data: BED, NARROWPEAK, TSV
Series
Accession:
GSE189861
ID:
200189861
2.

Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration and invasion

(Submitter supplied) Cleavage by the endonuclease CPSF73 and polyadenylation of nascent RNA is an essential step in co-transcriptional mRNA maturation, and abnormal poly(A) site choices have been associated with human diseases, including cancer. Recent work has surprisingly identified CPSF73 as a promising drug target for inhibiting the growth of specific cancers. However, our understanding of the regulation of CPSF73 is still at an early stage. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
9 Samples
Download data: CSV, TXT
Series
Accession:
GSE189746
ID:
200189746
3.

The role of ZNF32 in modulating transcriptoion of MCF-7

(Submitter supplied) Zinc finger protein 32 (ZNF32), is regarded as a transcription factor that regulates gene transcription. But the function of ZNF32 in breast cancer metastasis remains unknown. Here, the MCF-7 was transfected with the pENTER-ZNF32 or empty vector to search the target genes with ChIP-seq.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20301
2 Samples
Download data
Series
Accession:
GSE189718
ID:
200189718
4.

Next Generation Sequencing Fascilitates Quantitative Analysis of Differential Gene Expression in Human Pericytes treated with PDGF-BB

(Submitter supplied) PDGF-BB:PDGFRβ signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer’s disease (AD) is well documented. We used tissue microarrays from control and AD brains to determine if PDGF-BB:PDGFRβ signalling components were altered in AD, and found that there was a reduction in vascular expression of PDGFB. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
9 Samples
Download data: TXT
Series
Accession:
GSE189712
ID:
200189712
5.

Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma

(Submitter supplied) Enhanced expression of mitochondrial ribosomal proteins and marked reprogramming of the mitochondrial network are associated with sorafenib resistance in human cell lines and hepatocarcinoma patients, providing novel actionable targets for increasing therapeutic efficacy.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE189711
ID:
200189711
6.

Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL23976
220 Samples
Download data
Series
Accession:
GSE189673
ID:
200189673
7.

Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies [RNA-Seq]

(Submitter supplied) Purpose: Clustering of meningiomas using DNA methylation and RNA-sequencing data yields groups which predict clinical behavior than the current clinical standard of histopathologic grading. Both techniques segregate many common genomic features seen in meningiomas similarly, raising the question of whether they were identifying the same underyling groups. Methods: DNA methylation profiling (EPIC 850K array) and RNA-sequencing of 110 primary meningiomas was performed. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
110 Samples
Download data: CSV, XLSX
Series
Accession:
GSE189672
ID:
200189672
8.

Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies [Methylation array]

(Submitter supplied) Purpose: Clustering of meningiomas using DNA methylation and RNA-sequencing data yields groups which predict clinical behavior than the current clinical standard of histopathologic grading. Both techniques segregate many common genomic features seen in meningiomas similarly, raising the question of whether they were identifying the same underyling groups. Methods: DNA methylation profiling (EPIC 850K array) and RNA-sequencing of 110 primary meningiomas was performed. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL23976
110 Samples
Download data: CSV, XLSX
Series
Accession:
GSE189521
ID:
200189521
9.

Spatiotemporal transcriptional atlas of lung adenocarcinoma from adenocarcinoma in situ to invasive carcinoma [ST]

(Submitter supplied) To illuminate the evolutionary trajectory of LUAD from AIS to IAC, high-throughput scRNA-seq and ST data were generated and integrated to create a large-scale, single-cell spatiotemporal atlas of LUAD. We compiled a multi-omics atlas of the early-stage LUAD invasion process that reflects the heterogeneity of cancer cells, the competitive polyclonal origin of LUAD, signalling interactions between cancer cells and the TME, and the pseudo-chronological nature of LUAD invasion. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
6 Samples
Download data
Series
Accession:
GSE189487
ID:
200189487
10.

Spatiotemporal transcriptional atlas of lung adenocarcinoma from adenocarcinoma in situ to invasive carcinoma [scRNA-seq]

(Submitter supplied) To illuminate the evolutionary trajectory of LUAD from AIS to IAC, high-throughput scRNA-seq and ST data were generated and integrated to create a large-scale, single-cell spatiotemporal atlas of LUAD. We compiled a multi-omics atlas of the early-stage LUAD invasion process that reflects the heterogeneity of cancer cells, the competitive polyclonal origin of LUAD, signalling interactions between cancer cells and the TME, and the pseudo-chronological nature of LUAD invasion. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
9 Samples
Download data
Series
Accession:
GSE189357
ID:
200189357
11.

Expression profile of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis

(Submitter supplied) In order to identify new biomarkers for the diagnosis of rheumatoid arthritis, we used circRNA microarray technology to screen the differential expression of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis. We identified a total of 399 differentially expressed circRNAs in RA patients and healthy controls, of which 149 circRNAs were significantly up-regulated in RA patients and 250 were down-regulated. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL21825
8 Samples
Download data
Series
Accession:
GSE189338
ID:
200189338
12.

Targeting MyD88 Downregulates Inflammatory Mediators and Pathogenic Processes in PBMC From DMARDs-Naïve Rheumatoid Arthritis Patients

(Submitter supplied) Purpose: We analyzed RNA-seq from peripheral blood mononuclear cells (PBMC) in DMARDs-naïve RA patients and healthy subjects. Our goal was to evaluate the transcriptional profiles of ST2825-treated PBMC to identify its therapeutic potential. Methods: We analyzed bulk RNA-seq from peripheral blood mononuclear cells (PBMC) in DMARDs-naïve RA patients after stimulation with LPS and IL-1β, PBMC were treated with the MyD88 chemical inhibitor, ST2825. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
19 Samples
Download data: TXT
Series
Accession:
GSE189136
ID:
200189136
13.

circRNA maps in AhR antagonist treated K1 cells

(Submitter supplied) High-throughput data analysis was performed to identify the differentially expressed circRNAs in K1 control cell and AhR antagonist treated K1 cells. In total, 45 differentially expressed circRNAs were found.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20795
6 Samples
Download data: TXT
Series
Accession:
GSE188657
ID:
200188657
14.

Differential transcriptome between low and high-grade gliomas

(Submitter supplied) Glioblastoma (GB) is the most aggressive form of glioma and is characterized by a poor prognosis and high recurrence, despite intensive clinical interventions. To retrieve the key factors underlying the high malignancy of GB, we performed differential expression analysis between low and high-grade gliomas by using RNA-seq.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
11 Samples
Download data: TXT
Series
Accession:
GSE185861
ID:
200185861
15.

Unravelling the role of PAX2 mutation in human Focal Segmental Glomerulosclerosis

(Submitter supplied) We performed a genome­wide differential gene expression analysis by Ion AmpliSeqTM Transcriptome sequencing that targets more than 20,000 human genes to gain insights into the genes and pathways involved in the onset of familial steroid-resistant Focal Segmental Glomerulosclerosis (FSGS) driven by the presence of a heterozygous mutation in the PAX2 gene (PAX2G189R/+). Using a stepwise protocol, we differentiated control and PAX2G189R/+ induced pluripotent stem cells into podocytes and we performed whole-transcriptomic analysis on control and patient cells on days 6, 13 and 18 of differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24014
24 Samples
Download data
Series
Accession:
GSE185558
ID:
200185558
16.

Transcriptome analysis of naive CD4T cells from Granulomatosis with Polyangiitis(GPA) patients and healthy control (HC)

(Submitter supplied) Analysis of transcriptional profile of GPA and HC naive CD4 T cells to understand intrinsic molecular differences after early TCR activation that may explain different effector T cell genereation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
20 Samples
Download data
Series
Accession:
GSE184898
ID:
200184898
17.

Transcriptome-Wide Analysis of Human Liver Reveals Age-Related Differences in the Expression of Select Functional Gene Clusters and Evidence for a PPP1R10-Governed ‘Aging Cascade’.

(Submitter supplied) A transcriptome-wide analysis of human liver for demonstrating differences between young and old humans has not yet been performed. However, pinpointing major age-related alterations in hepatic gene expression may identify ontogenetic shifts with important hepatic and systemic con-sequences, provide novel pharmacogenetic information, offer clues to efficiently counteract symptoms of old age, and improve the overarching understanding of ontogeny and individual decline. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
17 Samples
Download data: TXT
Series
Accession:
GSE183915
ID:
200183915
18.

MicroRNA profiling of Gingival tissue from chronically SIV infected rhesus macaques

(Submitter supplied) The study describes miRNA expression in Gingival tissue of chronically SIV-infected rhesus macaques. HIV/SIV-associated periodontal disease (gingivitis/periodontitis) (PD) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Employing a systems biology approach, we report molecular changes underlying PD and its modulation by phytocannabinoids [delta-9-tetrahydrocannabinol (9-THC)] in uninfected and SIV-infected rhesus macaques (RMs) untreated (VEH-untreated/SIV) or treated with vehicle (VEH/SIV) or 9-THC (THC/SIV). more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL17837
13 Samples
Download data: TXT, XLS
Series
Accession:
GSE181541
ID:
200181541
19.

Epigenetic analysis of the low- and high-grade tumor component in a biphasic SMARCB1/INI1-deficient brain tumor (CNS LGDIT-INI1/ ATRT-MYC).

(Submitter supplied) The newly proposed entity CNS LGDIT-INI1 represents a low-grade tumor composed of inconspicuous SMARCB1-deficient tumor cells diffusely infiltrating the brain. Progression of CNS LGDIT-INI1 to ATRT(-MYC) has been reported. We published the first case report on a child harboring CNS LGDIT-INI1, which also featured a high-grade ATRT component. Moreover, we present the results of extensive spatial molecular profiling of this tumor.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
2 Samples
Download data: TXT
Series
Accession:
GSE181267
ID:
200181267
20.

Pathogenic mechanisms implied by plasma exosomal miRNA profile of preeclampsia with severe features

(Submitter supplied) Preeclampsia is a common complication of pregnancy that affects 4-5% of pregnant women around the world. At present, there is a lack of early identification of high-risk patients of preeclampsia in clinical practice, which restricts the development of disease prevention and treatment. Previous studies have indicated that plasma exosomal miRNAs in pregnant women could serve as biomarkers of preeclampsia, but few is focused on exosomal miRNAs from preeclampsia pregnancy with severe features(sPE). more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE175807
ID:
200175807
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