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aire autoimmune regulator [ Danio rerio (zebrafish) ]

Gene ID: 100007662, updated on 24-Apr-2022

Summary

Official Symbol
aireprovided by ZNC
Official Full Name
autoimmune regulatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071008-4
See related
Ensembl:ENSDARG00000056784 AllianceGenome:ZFIN:ZDB-GENE-071008-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-261l2.5
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See aire in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22808544..22826253)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (23153224..23170602)
103 previous assembly Zv9 (GCF_000002035.4) 2 NC_007113.5 (22266590..22283797)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene espin like b Neighboring gene RAB6B, member RAS oncogene family b Neighboring gene angiomotin like 2b Neighboring gene myosin VIIBb Neighboring gene uncharacterized LOC103910043

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in central tolerance induction to self antigen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within humoral immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative thymic T cell selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peripheral T cell tolerance induction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of thymocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thymus epithelium morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110014.1NP_001103484.1  autoimmune regulator

    See identical proteins and their annotated locations for NP_001103484.1

    Status: PROVISIONAL

    Source sequence(s)
    EU042187
    UniProtKB/TrEMBL
    A8HG42
    Related
    ENSDARP00000114968.1, ENSDART00000133250.3
    Conserved Domains (4) summary
    cd15539
    Location:294336
    PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
    cd15540
    Location:402439
    PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
    pfam03172
    Location:11107
    Sp100; Sp100 domain
    cl02536
    Location:197232
    SAND; SAND domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    22808544..22826253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298506.3XP_009296781.1  autoimmune regulator isoform X1

    Conserved Domains (4) summary
    cd15539
    Location:273315
    PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
    cd15540
    Location:381418
    PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
    pfam03172
    Location:11107
    Sp100; Sp100 domain
    cl02536
    Location:197232
    SAND; SAND domain