aire autoimmune regulator [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aireprovided by ZNC
Official Full Name: autoimmune regulatorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-071008-4
See related: Ensembl:ENSDARG00000056784 AllianceGenome:ZFIN:ZDB-GENE-071008-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-261l2.5
Summary: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (22808544..22826253)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (23153224..23170602)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in central tolerance induction to self antigen	IBA Inferred from Biological aspect of Ancestor more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	IEA Inferred from Electronic Annotation more info
involved_in negative thymic T cell selection	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral T cell tolerance induction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of thymocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymus epithelium morphogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: autoimmune regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110014.1 → NP_001103484.1 autoimmune regulator

See identical proteins and their annotated locations for NP_001103484.1

Status: PROVISIONAL

Source sequence(s)

EU042187

UniProtKB/TrEMBL

A8HG42

Related

ENSDARP00000114968.1, ENSDART00000133250.3

Conserved Domains (4) summary

cd15539
Location:294 → 336

PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)

cd15540
Location:402 → 439

PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)

pfam03172
Location:11 → 107

Sp100; Sp100 domain

cl02536
Location:197 → 232

SAND; SAND domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

22808544..22826253

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009298506.3 → XP_009296781.1 autoimmune regulator isoform X1

UniProtKB/TrEMBL

A0A8M3AQ73

Conserved Domains (4) summary

cd15539
Location:273 → 315

PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)

cd15540
Location:381 → 418

PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)

pfam03172
Location:11 → 107

Sp100; Sp100 domain

cl02536
Location:197 → 232

SAND; SAND domain