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mbl2 mannose binding lectin 2 [ Danio rerio (zebrafish) ]

Gene ID: 100008009, updated on 27-Mar-2024

Summary

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Official Symbol
mbl2provided by ZNC
Official Full Name
mannose binding lectin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-000427-2
See related
Ensembl:ENSDARG00000068220 AllianceGenome:ZFIN:ZDB-GENE-000427-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mbl; hbl3; fb68b07; wu:fb68b07; zgc:109836; etID42583.2
Summary
Predicted to enable carbohydrate binding activity. Predicted to be part of collagen trimer. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37887283..37889154, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37904826..37906764, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene cerebellin 13 Neighboring gene hexose-binding lectin 4 Neighboring gene hexose-binding lectin 2 Neighboring gene hexose-binding lectin 1 Neighboring gene telomerase-associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of human mannose binding lectin (MBL) recognition sites for novel inhibitory antibodies. Zhao H, et al. Hybrid Hybridomics, 2002 Feb. PMID 11991814
  2. Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus). Zhang H, et al. Res Vet Sci, 2012 Jun. PMID 21524427
  3. Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D. rerio) and identification of haplotypes resistant to L. anguillarum. Jackson AN, et al. Immunogenetics, 2007 Nov. PMID 17943278
  4. The homologue of mannose-binding lectin in the carp family Cyprinidae is expressed at high level in spleen, and the deduced primary structure predicts affinity for galactose. Vitved L, et al. Immunogenetics, 2000 Sep. PMID 11003389
  5. Response of complement expression to challenge with lipopolysaccharide in embryos/larvae of zebrafish Danio rerio: acquisition of immunocompetent complement. Wang Z, et al. Fish Shellfish Immunol, 2008 Sep. PMID 18657447

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. report multiple copies of MBL-like genes, with up to three copies tightly linked within a cluster spanning approximately 15 kb on chromosome 2
    Title: Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D. rerio) and identification of haplotypes resistant to L. anguillarum.
  2. MBL binding can be inhibited by at least two separate and independent mechanisms.
    Title: Identification of human mannose binding lectin (MBL) recognition sites for novel inhibitory antibodies.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC109836

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mannose-binding protein C; hexose-binding lectin 3
Names
GalBL
collectin
mannose binding-like lectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131570.2 → NP_571645.2  mannose-binding protein C precursor

    See identical proteins and their annotated locations for NP_571645.2

    Status: PROVISIONAL

    Source sequence(s)
    BC095009
    UniProtKB/TrEMBL
    A0A0R4IVR5, F6P0R9, Q504I3
    Related
    ENSDARP00000089300.3, ENSDART00000098529.5
    Conserved Domains (1) summary
    cd03591
    Location:135 → 248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37887283..37889154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171258.4 → XP_005171315.1  hexose-binding lectin 3 isoform X1

    See identical proteins and their annotated locations for XP_005171315.1

    UniProtKB/TrEMBL
    A0A0R4IVR5, F6P0R9, Q504I3
    Related
    ENSDARP00000139226.1, ENSDART00000168939.2
    Conserved Domains (1) summary
    cd03591
    Location:135 → 248
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394505.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    80934..82753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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