Format

Send to:

Choose Destination

PKM pyruvate kinase M1/2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008676, updated on 14-Jun-2019

Summary

Gene symbol
PKM
Gene description
pyruvate kinase M1/2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
PKM2
Annotation information
Annotation category: partial on reference assembly
Orthologs

Genomic context

See PKM in Genome Data Viewer
Location:
chromosome: 17
Exon count:
11
Annotation release Status Assembly Chr Location
102 current OryCun2.0 (GCF_000003625.3) 17 NC_013685.1 (304096..317843)

Chromosome 17 - NC_013685.1Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 6 Neighboring gene uncharacterized LOC108178239 Neighboring gene GRAM domain containing 2A Neighboring gene SUMO peptidase family member, NEDD8 specific

Genomic regions, transcripts, and products

Genomic Sequence:
NC_013685.1 Chromosome 17 Reference OryCun2.0 Primary Assembly

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
pyruvate kinase PKM
Names
ATP:pyruvate 2-o-phosphotransferase
Pyruvate kinase isozymes M1/M2
Pyruvate kinase muscle isozyme
pyruvate kinase, muscle
NP_001182573.1
NP_001182574.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195644.1NP_001182573.1  pyruvate kinase PKM isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame exon in the 3' coding region compared to variant 2. The resulting protein (isoform 1) has a different internal segment but is the same length as isoform 2.
    Source sequence(s)
    AAGW02071942, U44751
    UniProtKB/Swiss-Prot
    P11974
    Conserved Domains (2) summary
    cd00288
    Location:42530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:43527
    pyruv_kin; pyruvate kinase
  2. NM_001195645.1NP_001182574.1  pyruvate kinase PKM isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a different internal segment but is the same length as isoform 1.
    Source sequence(s)
    AAGW02071942, AF032389
    UniProtKB/Swiss-Prot
    P11974
    Conserved Domains (2) summary
    cd00288
    Location:42530
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:43527
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryCun2.0 Primary Assembly

Genomic

  1. NC_013685.1 Reference OryCun2.0 Primary Assembly

    Range
    304096..317843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center