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CLU clusterin [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008713, updated on 8-Mar-2024

Summary

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Gene symbol
CLU
Gene description
clusterin
See related
Ensembl:ENSOCUG00000005985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Summary
This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 2 NC_067375.1 (42540665..42557652)

Chromosome 2 - NC_067375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127487193 Neighboring gene coiled-coil domain containing 25 Neighboring gene scavenger receptor class A member 3 Neighboring gene uncharacterized LOC127487201 Neighboring gene L-gulonolactone oxidase Neighboring gene ADAM metallopeptidase domain 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067375.1 Chromosome 2 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Apolipoprotein J/clusterin is induced in vascular smooth muscle cells after vascular injury. Miyata M, et al. Circulation, 2001 Sep 18. PMID 11560857

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
clusterin
Names
apo-J
apolipoprotein J
apolipoprotein J/clusterin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082049.2 → NP_001075518.1  clusterin precursor

    See identical proteins and their annotated locations for NP_001075518.1

    Status: PROVISIONAL

    Source sequence(s)
    AF118852
    UniProtKB/Swiss-Prot
    Q9XSC5
    UniProtKB/TrEMBL
    A0A5F9C203
    Related
    ENSOCUP00000027725.1, ENSOCUT00000045082.1
    Conserved Domains (3) summary
    smart00030
    Location:22 → 225
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:226 → 441
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:29 → 443
    Clusterin; Clusterin

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067375.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    42540665..42557652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008273913.3 → XP_008272135.1  clusterin isoform X1

    UniProtKB/TrEMBL
    A0A5F9C203
    Related
    ENSOCUP00000005178.3
    Conserved Domains (3) summary
    smart00030
    Location:44 → 247
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:248 → 463
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:51 → 465
    Clusterin; Clusterin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XSC5.1 GenPept UniProtKB/Swiss-Prot:Q9XSC5

Gene LinkOut

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