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CLU clusterin [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008713, updated on 24-Jun-2020

Summary

Gene symbol
CLU
Gene description
clusterin
See related
Ensembl:ENSOCUG00000005985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Summary
This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Orthologs
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Genomic context

See CLU in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
102 current OryCun2.0 (GCF_000003625.3) 2 NC_013670.1 (42058787..42075844)

Chromosome 2 - NC_013670.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 25 Neighboring gene scavenger receptor class A member 3 Neighboring gene L-gulonolactone oxidase Neighboring gene uncharacterized LOC103345349

Genomic regions, transcripts, and products

Genomic Sequence:
NC_013670.1 Chromosome 2 Reference OryCun2.0 Primary Assembly

General protein information

Preferred Names
clusterin
Names
apo-J
apolipoprotein J
apolipoprotein J/clusterin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082049.2NP_001075518.1  clusterin precursor

    See identical proteins and their annotated locations for NP_001075518.1

    Status: PROVISIONAL

    Source sequence(s)
    AF118852
    UniProtKB/Swiss-Prot
    Q9XSC5
    Related
    ENSOCUP00000027725.1, ENSOCUT00000045082.1
    Conserved Domains (3) summary
    smart00030
    Location:22225
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:226441
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:29443
    Clusterin; Clusterin

RefSeqs of Annotated Genomes: Oryctolagus cuniculus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference OryCun2.0 Primary Assembly

Genomic

  1. NC_013670.1 Reference OryCun2.0 Primary Assembly

    Range
    42058787..42075844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008273906.2XP_008272128.1  clusterin isoform X1

    Conserved Domains (3) summary
    smart00030
    Location:77280
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:281496
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:84498
    Clusterin; Clusterin
  2. XM_008273913.2XP_008272135.1  clusterin isoform X2

    Related
    ENSOCUP00000005178.3, ENSOCUT00000005984.4
    Conserved Domains (3) summary
    smart00030
    Location:44247
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:248463
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:51465
    Clusterin; Clusterin
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