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ALDOA aldolase, fructose-bisphosphate A [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009055, updated on 8-Mar-2024

Summary

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Gene symbol
ALDOA
Gene description
aldolase, fructose-bisphosphate A
See related
Ensembl:ENSOCUG00000006329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 6 NC_067379.1 (18435655..18440976)

Chromosome 6 - NC_067379.1Genomic Context describing neighboring genes Neighboring gene chromosome 6 C16orf92 homolog Neighboring gene keratin-associated protein 10-2 Neighboring gene TLC domain containing 3B Neighboring gene protein phosphatase 4 catalytic subunit Neighboring gene T-box transcription factor 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067379.1 Chromosome 6 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase. Park H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 May 1. PMID 20445268, Free PMC Article
  2. Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase. St-Jean M, et al. Biochemistry, 2009 Jun 2. PMID 19354220
  3. A conserved glutamate residue exhibits multifunctional catalytic roles in D-fructose-1,6-bisphosphate aldolases. Maurady A, et al. J Biol Chem, 2002 Mar 15. PMID 11779856
  4. Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,). Choi KH, et al. Biochemistry, 1999 Sep 28. PMID 10504235
  5. Product binding and role of the C-terminal region in class I D-fructose 1,6-bisphosphate aldolase. Blom N, et al. Nat Struct Biol, 1997 Jan. PMID 8989320

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lattice of muscle aldolase contacts corresponded to an increased number of interactions between high-entropy side chains that mitigate the lattice strain incurred upon cryocooling and accompanying mosaic spread increases.
    Title: Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase.
  2. kinetic and structural analyses of fructose-bisphosphate aldolase
    Title: Charge stabilization and entropy reduction of central lysine residues in fructose-bisphosphate aldolase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fructose-bisphosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fructose 1,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fructose-bisphosphate aldolase A
Names
aldolase A, fructose-bisphosphate
muscle-type aldolase
NP_001075707.1
XP_008256151.1
XP_008256152.1
XP_017197922.1
XP_017197924.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082238.1 → NP_001075707.1  fructose-bisphosphate aldolase A

    See identical proteins and their annotated locations for NP_001075707.1

    Status: VALIDATED

    Source sequence(s)
    K02300
    UniProtKB/Swiss-Prot
    P00883, Q28671
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067379.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    18435655..18440976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008257930.3 → XP_008256152.1  fructose-bisphosphate aldolase A isoform X2

    See identical proteins and their annotated locations for XP_008256152.1

    UniProtKB/Swiss-Prot
    P00883, Q28671
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

  2. XM_017342435.2 → XP_017197924.1  fructose-bisphosphate aldolase A isoform X2

    UniProtKB/Swiss-Prot
    P00883, Q28671
    Related
    ENSOCUP00000008499.2
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

  3. XM_008257929.3 → XP_008256151.1  fructose-bisphosphate aldolase A isoform X2

    See identical proteins and their annotated locations for XP_008256151.1

    UniProtKB/Swiss-Prot
    P00883, Q28671
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

  4. XM_017342433.1 → XP_017197922.1  fructose-bisphosphate aldolase A isoform X1

    UniProtKB/TrEMBL
    A0A5F9D5U7
    Related
    ENSOCUP00000041095.1, ENSOCUT00000055841.1
    Conserved Domains (1) summary
    pfam00274
    Location:70 → 419
    Glycolytic; Fructose-bisphosphate aldolase class-I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00883.2 GenPept UniProtKB/Swiss-Prot:P00883

Gene LinkOut

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