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HBB2 hemoglobin, beta [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009084, updated on 9-Nov-2023

Summary

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Gene symbol
HBB2
Gene description
hemoglobin, beta
See related
Ensembl:ENSOCUG00000000568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
HBB; HBB1
Summary
The adult hemoglobin is a heterotetramer of two alpha chains and two beta chains, and functions in the transport of oxygen from the lungs to various peripheral tissues. This gene is expressed in red blood cells and encodes the beta polypeptide chain. Studies have shown that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, both in rabbit reticulocyte lysates and in intact reticulocytes. [provided by RefSeq, Feb 2016]
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Genomic context

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See HBB2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (160096096..160097597, complement)

Chromosome 1 - NC_067374.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 52P1-like Neighboring gene olfactory receptor 52Z1P-like Neighboring gene hemoglobin subunit beta-1/2 Neighboring gene hemoglobin, gamma G

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rabbit beta-globin is extended beyond its UGA stop codon by multiple suppressions and translational reading gaps. Chittum HS, et al. Biochemistry, 1998 Aug 4. PMID 9692979
  2. A UGA termination suppression tRNATrp active in rabbit reticulocytes. Geller AI, et al. Nature, 1980 Jan 3. PMID 7350525
  3. Haemoglobins, XVII. The primary structure of the beta-chain of rabbit haemoglobin. Best JS, et al. Hoppe Seylers Z Physiol Chem, 1969 May. PMID 5789874
  4. Genetic variation in the primary structure of the beta chain of rabbit hemoglobin. Garrick MD, et al. Ann N Y Acad Sci, 1974 Nov 29. PMID 4530669
  5. Immunopurification of the suppressor tRNA dependent rabbit beta-globin readthrough protein. Hatfield D, et al. Biochemistry, 1988 Feb 23. PMID 3365379

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A comparative study of tetrameric rabbit hemoglobin and monomeric soybean leghemoglobin a in the oxy- and deoxy-forms was carried out using (57)Fe Mossbauer spectroscopy
    Title: Comparative analysis of the heme iron electronic structure and stereochemistry in tetrameric rabbit hemoglobin and monomeric soybean leghemoglobin a using Mössbauer spectroscopy with a high velocity resolution.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables haptoglobin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hemoglobin alpha binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables organic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in oxygen transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of haptoglobin-hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of hemoglobin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hemoglobin subunit beta-1/2
Names
beta globin
beta-1/2-globin
hemoglobin beta-1/2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082260.3 → NP_001075729.2  hemoglobin subunit beta-1/2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 707-709), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAA termination codon (nt 776-778). This RefSeq represents the shorter isoform.
    Source sequence(s)
    EB379014, GBCI01005570
    UniProtKB/TrEMBL
    A0A1K0GV16, A0A5F9D756
    Related
    ENSOCUP00000042019.1, ENSOCUT00000036183.1
    Conserved Domains (1) summary
    cd08925
    Location:7 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

  2. NM_001314043.1 → NP_001300972.1  hemoglobin subunit beta-1/2 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This transcript (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 707-709), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAA termination codon (nt 776-778). This RefSeq represents the longer, C-terminally extended isoform. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    EB379014, GBCI01005570
    UniProtKB/TrEMBL
    A0A5F9D756
    Related
    ENSOCUP00000000491.3, ENSOCUT00000000567.4
    Conserved Domains (1) summary
    cd08925
    Location:7 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067374.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    160096096..160097597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02057.2 GenPept UniProtKB/Swiss-Prot:P02057

Gene LinkOut

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Research Materials