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PNLIP pancreatic lipase [ Equus caballus (horse) ]

Gene ID: 100034202, updated on 8-Mar-2024

Summary

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Official Symbol
PNLIPprovided by VGNC
Official Full Name
pancreatic lipaseprovided by VGNC
Primary source
VGNC:VGNC:109377
See related
Ensembl:ENSECAG00000009446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
PL; PTL; LIPASE
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (15653373..15670389, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 1 NC_009144.2 (15534768..15551780, complement)

Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene pancreatic lipase related protein 2 Neighboring gene pancreatic lipase related protein 1 Neighboring gene pancreatic lipase related protein 3 Neighboring gene coiled-coil domain containing 172

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Horse pancreatic lipase. The crystal structure refined at 2.3 A resolution. Bourne Y, et al. J Mol Biol, 1994 May 20. PMID 8182745
  2. Sequence of horse pancreatic lipase as determined by protein and cDNA sequencing. Implications for p-nitrophenyl acetate hydrolysis by pancreatic lipases. Kerfelec B, et al. Eur J Biochem, 1992 May 15. PMID 1587279
  3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pancreatic triacylglycerol lipase
NP_001157421.1
XP_014588446.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163949.1 → NP_001157421.1  pancreatic triacylglycerol lipase precursor

    See identical proteins and their annotated locations for NP_001157421.1

    Status: VALIDATED

    Source sequence(s)
    PJAA01000002, X66218
    UniProtKB/Swiss-Prot
    P29183
    UniProtKB/TrEMBL
    F7BR43
    Related
    ENSECAP00000007877.1, ENSECAT00000010231.3
    Conserved Domains (3) summary
    cd00707
    Location:51 → 348
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:355 → 465
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18 → 352
    Lipase; Lipase

RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009144.3 Reference EquCab3.0 Primary Assembly

    Range
    15653373..15670389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014732960.1 → XP_014588446.1  pancreatic triacylglycerol lipase isoform X1

    UniProtKB/Swiss-Prot
    P29183
    UniProtKB/TrEMBL
    F7BR43
    Conserved Domains (3) summary
    cd00707
    Location:51 → 348
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:355 → 465
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18 → 352
    Lipase; Lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29183.2 GenPept UniProtKB/Swiss-Prot:P29183

Gene LinkOut

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