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Wfdc17 WAP four-disulfide core domain 17 [ Mus musculus (house mouse) ]

Gene ID: 100034251, updated on 23-Jun-2021

Summary

Official Symbol
Wfdc17provided by MGI
Official Full Name
WAP four-disulfide core domain 17provided by MGI
Primary source
MGI:MGI:3649773
See related
Ensembl:ENSMUSG00000069792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amwap; Gm11428
Expression
Broad expression in bladder adult (RPKM 10.5), mammary gland adult (RPKM 8.0) and 15 other tissues See more
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Genomic context

See Wfdc17 in Genome Data Viewer
Location:
11 C; 11
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83594882..83597095)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83704056..83706269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (83517558..83519771)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11432 Neighboring gene predicted gene 11430 Neighboring gene WAP four-disulfide core domain 18 Neighboring gene WAP four-disulfide core domain 21

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activated macrophage/microglia WAP domain protein
Names
extracellular proteinase inhibitor family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081957.1NP_001075426.1  activated macrophage/microglia WAP domain protein precursor

    See identical proteins and their annotated locations for NP_001075426.1

    Status: VALIDATED

    Source sequence(s)
    BC089618, W08116
    Consensus CDS
    CCDS36257.1
    UniProtKB/TrEMBL
    Q5SSJ1
    Related
    ENSMUSP00000090511.6, ENSMUST00000092836.6
    Conserved Domains (1) summary
    cd00199
    Location:1675
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83594882..83597095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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