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Cldn24 claudin 24 [ Mus musculus (house mouse) ]

Gene ID: 100039801, updated on 23-Jun-2021

Summary

Official Symbol
Cldn24provided by MGI
Official Full Name
claudin 24provided by MGI
Primary source
MGI:MGI:3712484
See related
Ensembl:ENSMUSG00000061974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm10107
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the human homolog. Similar to the human gene, this gene is upstream of the Cldn22 gene, which overlaps the Wwc2 gene on the opposite strand. [provided by RefSeq, Aug 2010]
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Genomic context

See Cldn24 in Genome Data Viewer
Location:
8; 8 B1.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48275178..48275840)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47822143..47822805)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (48907497..48908159)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31786 Neighboring gene RIKEN cDNA 1700061N14 gene Neighboring gene claudin 22 Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene predicted gene, 39173

Genomic regions, transcripts, and products

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111318.1NP_001104788.1  putative claudin-24

    See identical proteins and their annotated locations for NP_001104788.1

    Status: REVIEWED

    Source sequence(s)
    CH466554
    Consensus CDS
    CCDS52549.1
    UniProtKB/TrEMBL
    D3YXJ9
    Related
    ENSMUSP00000078584.3, ENSMUST00000079639.3
    Conserved Domains (1) summary
    cl21598
    Location:7183
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    48275178..48275840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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