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Ccl27b C-C motif chemokine ligand 27b [ Mus musculus (house mouse) ]

Gene ID: 100040048, updated on 8-Feb-2024

Summary

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Official Symbol
Ccl27bprovided by MGI
Official Full Name
C-C motif chemokine ligand 27bprovided by MGI
Primary source
MGI:MGI:1891389
See related
Ensembl:ENSMUSG00000096826 AllianceGenome:MGI:1891389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctack; Scya27b
Summary
Predicted to enable CCR3 chemokine receptor binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Is expressed in pelvic ganglion; urethra of female; and urethra of male. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 30.8), testis adult (RPKM 20.9) and 15 other tissues See more
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Genomic context

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Location:
4 A5; 4 22.73 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42650563..42656008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42650563..42656008)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 19, pseudogene 2 Neighboring gene C-C motif chemokine ligand 21E Neighboring gene C-C motif chemokine ligand 19, pseudogene 4 Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene interleukin 11 receptor subunit alpha 2 Neighboring gene predicted gene, 53182 Neighboring gene family with sequence similarity 205 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues. Davila ML, et al. iScience, 2022 Jun 17. PMID 35663027, Free PMC Article
  2. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. Nakano H, et al. J Immunol, 2001 Jan 1. PMID 11123313
  3. Chemokine/chemokine receptor nomenclature. IUIS/WHO Subcommittee on Chemokine Nomenclature. J Immunol Methods, 2002 Apr 1. PMID 12080938
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
chemokine (C-C motif) ligand 27b
Names
small inducible cytokine A27b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199959.2 → NP_001186888.1  chemokine (C-C motif) ligand 27b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186888.1

    Status: VALIDATED

    Source sequence(s)
    BX548253
    Consensus CDS
    CCDS51159.1
    UniProtKB/Swiss-Prot
    Q3KNL1, Q9DAU6, Q9DAZ4, Q9Z1X0
    UniProtKB/TrEMBL
    A2AMS5
    Related
    ENSMUSP00000137284.2, ENSMUST00000177785.3
    Conserved Domains (1) summary
    cl00134
    Location:34 → 83
    Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

  2. NM_001199960.2 → NP_001186889.1  chemokine (C-C motif) ligand 27b isoform 3

    See identical proteins and their annotated locations for NP_001186889.1

    Status: VALIDATED

    Source sequence(s)
    BX548253
    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  3. NM_001199961.2 → NP_001186890.1  chemokine (C-C motif) ligand 27b isoform 1

    See identical proteins and their annotated locations for NP_001186890.1

    Status: VALIDATED

    Source sequence(s)
    BX548253
    UniProtKB/Swiss-Prot
    Q9Z1X0
    Conserved Domains (1) summary
    cl00134
    Location:49 → 98
    Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

  4. NM_001384259.1 → NP_001371188.1  chemokine (C-C motif) ligand 27b isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX548253
    Conserved Domains (1) summary
    pfam00048
    Location:72 → 132
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  5. NM_001384260.1 → NP_001371189.1  chemokine (C-C motif) ligand 27b isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX548253
    Conserved Domains (1) summary
    pfam00048
    Location:92 → 152
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    42650563..42656008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163520.1 → XP_036019413.1  chemokine (C-C motif) ligand 27b isoform X1

    Conserved Domains (1) summary
    pfam00048
    Location:94 → 154
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  2. XM_036163521.1 → XP_036019414.1  chemokine (C-C motif) ligand 27b isoform X2

    Conserved Domains (1) summary
    pfam00048
    Location:74 → 134
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  3. XM_036163522.1 → XP_036019415.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  4. XM_036163525.1 → XP_036019418.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  5. XM_036163524.1 → XP_036019417.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  6. XM_036163523.1 → XP_036019416.1  chemokine (C-C motif) ligand 27b isoform X3

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

  7. XM_006537503.3 → XP_006537566.1  chemokine (C-C motif) ligand 27b isoform X3

    See identical proteins and their annotated locations for XP_006537566.1

    Conserved Domains (1) summary
    pfam00048
    Location:39 → 99
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RNA

  1. XR_004941788.1 RNA Sequence

  2. XR_004941789.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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