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Supt4b SPT4B, DSIF elongation factor subunit [ Mus musculus (house mouse) ]

Gene ID: 100041294, updated on 11-Apr-2024

Summary

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Official Symbol
Supt4bprovided by MGI
Official Full Name
SPT4B, DSIF elongation factor subunitprovided by MGI
Primary source
MGI:MGI:1335090
See related
AllianceGenome:MGI:1335090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm3258; Supt4h2; Supt4h1b
Summary
Predicted to enable RNA polymerase II complex binding activity and protein heterodimerization activity. Predicted to be involved in RNA metabolic process; chromatin organization; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in brain; embryo; heart; and liver. Orthologous to human SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
10 A4; 10 17.4 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31289722..31290431, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31413726..31414435, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene HD domain containing 2 Neighboring gene tumor protein D52-like 1 Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764 Neighboring gene ring finger protein 217 Neighboring gene STARR-seq mESC enhancer starr_26216 Neighboring gene high mobility group box 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of murine Supt4h and a nearly identical expressed, processed gene: evidence of sequence conservation through gene conversion extending into the untranslated regions. Chiang PW, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776760, Free PMC Article
  2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription, elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription, elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DSIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DSIF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription elongation factor SPT4-B
Names
DRB sensitivity-inducing factor small subunit 2
DSIF small subunit 2
suppressor of Ty 4 homolog 2
suppressor of Ty 4B
transcription elongation factor SPT4 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011509.2 → NP_035639.1  transcription elongation factor SPT4-B

    See identical proteins and their annotated locations for NP_035639.1

    Status: VALIDATED

    Source sequence(s)
    AC153729, EL607674
    UniProtKB/Swiss-Prot
    Q9Z199
    Conserved Domains (1) summary
    cd07973
    Location:11 → 108
    Spt4; Transcription elongation factor Spt4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    31289722..31290431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z199.1 GenPept UniProtKB/Swiss-Prot:Q9Z199

Gene LinkOut

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