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Hsd3b9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9 [ Mus musculus (house mouse) ]

Gene ID: 100043461, updated on 8-Feb-2024

Summary

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Official Symbol
Hsd3b9provided by MGI
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9provided by MGI
Primary source
MGI:MGI:3782634
See related
Ensembl:ENSMUSG00000090817 AllianceGenome:MGI:3782634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4450
Summary
Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase activity and steroid delta-isomerase activity. Predicted to be involved in several processes, including C21-steroid hormone metabolic process; hippocampus development; and response to corticosterone. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 427.6) See more
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Genomic context

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Location:
3 F2.2; 3 42.77 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98352991..98364833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98445675..98457517, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4565 Neighboring gene STARR-positive B cell enhancer ABC_E11203 Neighboring gene 3-phosphoglycerate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E7932 Neighboring gene predicted gene, 31420 Neighboring gene zinc finger protein 697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98210571-98210772 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of several members of the murine Hsd3b gene family. Clarke TR, et al. DNA Cell Biol, 1996 May. PMID 8924213
  2. The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3. Bain PA, et al. Genomics, 1993 Apr. PMID 8486361
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding ISO
Inferred from Sequence Orthology
more info
  
enables steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippocampus development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to corticosterone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADPH-dependent 3-keto-steroid reductase Hsd3b4
Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like
NP_001357799.1
XP_001480548.2
XP_011238657.1
XP_017175350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370870.1 → NP_001357799.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4

    Status: VALIDATED

    Source sequence(s)
    AC161053
    Consensus CDS
    CCDS89670.1
    UniProtKB/TrEMBL
    E9Q007
    Related
    ENSMUSP00000127882.2, ENSMUST00000167753.8
    Conserved Domains (1) summary
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    98352991..98364833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319861.2 → XP_017175350.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X2

    UniProtKB/TrEMBL
    E9Q007
    Conserved Domains (1) summary
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_001480498.5 → XP_001480548.2  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:31 → 383
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_011240355.1 → XP_011238657.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X2

    See identical proteins and their annotated locations for XP_011238657.1

    UniProtKB/TrEMBL
    E9Q007
    Conserved Domains (1) summary
    cl21454
    Location:5 → 357
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version

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