U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srcap Snf2-related CREBBP activator protein [ Mus musculus (house mouse) ]

Gene ID: 100043597, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Srcapprovided by MGI
Official Full Name
Snf2-related CREBBP activator proteinprovided by MGI
Primary source
MGI:MGI:2444036
See related
Ensembl:ENSMUSG00000053877 AllianceGenome:MGI:2444036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B930091H02Rik; D030022P06Rik; F630004O05Rik
Summary
Predicted to enable ATP hydrolysis activity and histone binding activity. Predicted to be involved in histone exchange. Predicted to be located in Golgi apparatus; nuclear body; and perinuclear region of cytoplasm. Predicted to be part of Swr1 complex. Is expressed in early conceptus; inner cell mass; and oocyte. Human ortholog(s) of this gene implicated in Floating-Harbor syndrome. Orthologous to human SRCAP (Snf2 related CREBBP activator protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 33.8), spleen adult (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Srcap in Genome Data Viewer
Location:
7 F3; 7 69.56 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127111155..127160391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127511983..127561219)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134614302-134614485 Neighboring gene STARR-positive B cell enhancer ABC_E1742 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621461-134621644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621862-134622045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134623956-134624143 Neighboring gene proline rich 14 Neighboring gene fibrosin Neighboring gene microRNA 7060 Neighboring gene RIKEN cDNA 1700008J07 gene Neighboring gene STARR-seq mESC enhancer starr_20184 Neighboring gene STARR-seq mESC enhancer starr_20185 Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134716729-134716937 Neighboring gene phosphorylase kinase, gamma 2 (testis)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. Ye B, et al. EMBO J, 2020 Jul 1. PMID 32449550, Free PMC Article
  2. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Ruhl DD, et al. Biochemistry, 2006 May 2. PMID 16634648
  3. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
    Title: SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.
  2. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
    Title: The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
helicase SRCAP
Names
Snf2-related CBP activator protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304266.1 → NP_001291195.1  helicase SRCAP

    Status: VALIDATED

    Source sequence(s)
    AC122417, AI549885, AK142089, BQ770450, BU055896, CF161846, CJ206221, CN537242, CN664718
    Consensus CDS
    CCDS80806.1
    UniProtKB/TrEMBL
    A0A087WNL7, A0A087WQ44
    Related
    ENSMUSP00000140036.2, ENSMUST00000187040.7
    Conserved Domains (6) summary
    cd00046
    Location:650 → 789
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:633 → 919
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:2042 → 2156
    Helicase_C; Helicase conserved C-terminal domain
    pfam07529
    Location:127 → 196
    HSA; HSA
    pfam15741
    Location:1500 → 1700
    LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
    cl23750
    Location:2240 → 2354
    vATP-synt_E; ATP synthase (E/31 kDa) subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127111155..127160391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033881.1: Suppressed sequence

    Description
    NM_001033881.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_175144.2: Suppressed sequence

    Description
    NM_175144.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  3. NM_178800.1: Suppressed sequence

    Description
    NM_178800.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous