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Zfp850 zinc finger protein 850 [ Mus musculus (house mouse) ]

Gene ID: 100043772, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp850provided by MGI
Official Full Name
zinc finger protein 850provided by MGI
Primary source
MGI:MGI:3036281
See related
Ensembl:ENSMUSG00000096916 AllianceGenome:MGI:3036281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4636; C130069I09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp850 in Genome Data Viewer
Location:
7 A3; 7 15.97 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27683896..27713634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27984471..28014210, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 780B Neighboring gene STARR-positive B cell enhancer ABC_E2231 Neighboring gene vomeronasal 1 receptor, pseudogene 87 Neighboring gene STARR-positive B cell enhancer ABC_E1084 Neighboring gene STARR-seq mESC enhancer starr_18400 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 4 Neighboring gene Fc fragment of IgG binding protein Neighboring gene tectorin alpha pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC35631

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 850

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001254951.1 → NP_001241880.1  zinc finger protein 850

    See identical proteins and their annotated locations for NP_001241880.1

    Status: VALIDATED

    Source sequence(s)
    AC139063, AC158220, BU925220, CF735501
    Consensus CDS
    CCDS57531.1
    UniProtKB/TrEMBL
    A0A087WSI7, J3QPC5
    Related
    ENSMUSP00000141063.3, ENSMUST00000180502.8
    Conserved Domains (4) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:279 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:202 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:256 → 278
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27683896..27713634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250406.4 → XP_011248708.1  zinc finger protein 850 isoform X1

    See identical proteins and their annotated locations for XP_011248708.1

    UniProtKB/TrEMBL
    A0A087WSI7, J3QPC5
    Related
    ENSMUSP00000137192.2, ENSMUST00000180024.2
    Conserved Domains (4) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:279 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:202 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:256 → 278
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_011250405.4 → XP_011248707.1  zinc finger protein 850 isoform X1

    See identical proteins and their annotated locations for XP_011248707.1

    UniProtKB/TrEMBL
    A0A087WSI7, J3QPC5
    Conserved Domains (4) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:279 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:202 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:256 → 278
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_011250404.4 → XP_011248706.1  zinc finger protein 850 isoform X1

    See identical proteins and their annotated locations for XP_011248706.1

    UniProtKB/TrEMBL
    A0A087WSI7, J3QPC5
    Conserved Domains (4) summary
    smart00349
    Location:14 → 75
    KRAB; krueppel associated box
    COG5048
    Location:279 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:202 → 222
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:256 → 278
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_036152497.1 → XP_036008390.1  zinc finger protein 850 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:244 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221 → 243
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:18 → 40
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. XM_030241930.2 → XP_030097790.1  zinc finger protein 850 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:244 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221 → 243
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:18 → 40
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. XM_036152496.1 → XP_036008389.1  zinc finger protein 850 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:244 → 636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167 → 187
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:221 → 243
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:18 → 40
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001100456.1: Suppressed sequence

    Description
    NM_001100456.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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