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blm BLM RecQ like helicase [ Oryzias latipes (Japanese medaka) ]

Gene ID: 100049173, updated on 8-Mar-2024

Summary

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Gene symbol
blm
Gene description
BLM RecQ like helicase
See related
EnsemblRapid:ENSORLG00000008110
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 6
Exon count:
22
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 6 NC_019864.2 (17782233..17792148, complement)
102 previous assembly ASM31367v1 (GCF_000313675.1) 6 NC_019864.1 (12572554..12579491, complement)

Chromosome 6 - NC_019864.2Genomic Context describing neighboring genes Neighboring gene transfer RNA histidin (anticodon GUG) Neighboring gene FERM domain containing 5 Neighboring gene cathepsin H Neighboring gene Ras protein specific guanine nucleotide releasing factor 1 Neighboring gene uncharacterized LOC110013814

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation of medaka gene knockout models by target-selected mutagenesis. Taniguchi Y, et al. Genome Biol, 2006. PMID 17156454, Free PMC Article
  2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Bloom syndrome protein
Names
Bloom syndrome RecQ like helicase
Bloom syndrome helicase
NP_001098120.1
XP_023811136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104650.1 → NP_001098120.1  Bloom syndrome protein

    See identical proteins and their annotated locations for NP_001098120.1

    Status: PROVISIONAL

    Source sequence(s)
    EF486797
    UniProtKB/TrEMBL
    A0A3B3H755, A4UTP8
    Related
    ENSORLP00000027048.1, ENSORLT00000031161.1
    Conserved Domains (8) summary
    smart00341
    Location:1191 → 1266
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:636 → 1120
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    smart00956
    Location:1055 → 1159
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:840 → 971
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:651 → 820
    DEAD; DEAD/DEAH box helicase
    pfam08072
    Location:360 → 397
    BDHCT; BDHCT (NUC031) domain
    pfam16124
    Location:976 → 1045
    RecQ_Zn_bind; RecQ zinc-binding
    pfam16202
    Location:1 → 323
    BLM_N; N-terminal region of Bloom syndrome protein

RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019864.2 Reference ASM223467v1 Primary Assembly

    Range
    17782233..17792148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023955368.1 → XP_023811136.1  Bloom syndrome protein isoform X1

    UniProtKB/TrEMBL
    A0A3P9IC12, H2LVP4
    Related
    ENSORLP00000010178.4, ENSORLT00000010179.4
    Conserved Domains (4) summary
    smart00341
    Location:1161 → 1236
    HRDC; Helicase and RNase D C-terminal
    pfam08072
    Location:330 → 369
    BDHCT; BDHCT (NUC031) domain
    pfam16202
    Location:1 → 293
    BLM_N; N-terminal region of Bloom syndrome protein
    cl26939
    Location:606 → 1090
    DEXDc; DEAD-like helicases superfamily
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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