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tp53 tumor protein p53 [ Oryzias latipes (Japanese medaka) ]

Gene ID: 100049321, updated on 8-Mar-2024

Summary

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Gene symbol
tp53
Gene description
tumor protein p53
See related
EnsemblRapid:ENSORLG00000006390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
p53
Orthologs
human zebrafish all
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Genomic context

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See tp53 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 18 NC_019876.2 (14488466..14497260)
102 previous assembly ASM31367v1 (GCF_000313675.1) 18 NC_019876.1 (15005133..15014025)

Chromosome 18 - NC_019876.2Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y-box binding protein 2 Neighboring gene solute carrier family 2 member 4 Neighboring gene receptor-type tyrosine-protein phosphatase eta-like Neighboring gene receptor-type tyrosine-protein phosphatase eta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo. Yasuda T, et al. J Radiat Res, 2016 Jan. PMID 26410759, Free PMC Article
  2. p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes). Isoe Y, et al. Biochem Biophys Res Commun, 2012 Jul 13. PMID 22659737
  3. Lack of ultraviolet-light inducibility of the medakafish (Oryzias latipes) tumor suppressor gene p53. Chen S, et al. Gene, 2001 Feb 21. PMID 11250074
  4. Cloning of the p53 tumor suppressor gene from the Japanese medaka (Oryzias latipes) and evaluation of mutational hotspots in MNNG-exposed fish. Krause MK, et al. Gene, 1997 Apr 11. PMID 9161419
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p53 is not essential for tissue self-renewal in developing brain.
    Title: Irradiation-injured brain tissues can self-renew in the absence of the pivotal tumor suppressor p53 in the medaka (Oryzias latipes) embryo.
  2. These results suggest that p53 positively regulates neurogenesis via cell proliferation.
    Title: p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes).
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cellular tumor antigen p53
Names
tumor suppressor p53
tumor suppressor protein p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104742.1 → NP_001098212.1  cellular tumor antigen p53

    See identical proteins and their annotated locations for NP_001098212.1

    Status: PROVISIONAL

    Source sequence(s)
    AF003949
    UniProtKB/Swiss-Prot
    P79820, Q9PSU7, Q9PSU8
    UniProtKB/TrEMBL
    A0A3P9HF25
    Related
    ENSORLP00000008031.3, ENSORLT00000008032.3
    Conserved Domains (2) summary
    pfam07710
    Location:299 → 335
    P53_tetramer; P53 tetramerisation motif
    cl14608
    Location:87 → 270
    P53; P53 DNA-binding domain

RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019876.2 Reference ASM223467v1 Primary Assembly

    Range
    14488466..14497260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023965765.1 → XP_023821533.1  cellular tumor antigen p53 isoform X1

    UniProtKB/TrEMBL
    A0A3P9HF25, Q71TU9
    Related
    ENSORLP00000068455.1, ENSORLT00000050759.1
    Conserved Domains (2) summary
    pfam07710
    Location:298 → 334
    P53_tetramer; P53 tetramerisation motif
    cl14608
    Location:86 → 269
    P53; P53 DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79820.2 GenPept UniProtKB/Swiss-Prot:P79820

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.