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SERPINB1 serpin family B member 1 [ Equus caballus (horse) ]

Gene ID: 100049797, updated on 8-Mar-2024

Summary

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Official Symbol
SERPINB1provided by VGNC
Official Full Name
serpin family B member 1provided by VGNC
Primary source
VGNC:VGNC:22847
See related
Ensembl:ENSECAG00000009896
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human all
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Genomic context

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Location:
chromosome: 20
Exon count:
10
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 20 NC_009163.3 (3551439..3591824, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 20 NC_009163.2 (3298136..3336461, complement)

Chromosome 20 - NC_009163.3Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase family member 4 Neighboring gene WRN helicase interacting protein 1 Neighboring gene serpin family B member 9 Neighboring gene serpin family B member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes. Kordula T, et al. Biochem J, 1993 Jul 1. PMID 7687128, Free PMC Article
  2. An elastase inhibitor from equine leukocyte cytosol belongs to the serpin superfamily. Further characterization and amino acid sequence of the reactive center. Potempa J, et al. J Biol Chem, 1988 May 25. PMID 3366785
  3. Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein. Dubin A, et al. J Biol Chem, 1992 Apr 5. PMID 1551869
  4. Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution. Baumann U, et al. J Mol Biol, 1992 Aug 20. PMID 1518052
  5. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
leukocyte elastase inhibitor
Names
LEI
leukocyte elastase inhibitor A-like protein
leukocyte elastase inhibitor-like protein
serpin B1
serpin peptidase inhibitor, clade B (ovalbumin), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081947.1 → NP_001075416.1  leukocyte elastase inhibitor

    See identical proteins and their annotated locations for NP_001075416.1

    Status: PROVISIONAL

    Source sequence(s)
    M91161
    UniProtKB/Swiss-Prot
    P05619
    UniProtKB/TrEMBL
    K9K3A1
    Related
    ENSECAP00000057455.1, ENSECAT00000088400.1
    Conserved Domains (1) summary
    cd02058
    Location:4 → 379
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009163.3 Reference EquCab3.0 Primary Assembly

    Range
    3551439..3591824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005603498.3 → XP_005603555.1  leukocyte elastase inhibitor isoform X1

    See identical proteins and their annotated locations for XP_005603555.1

    UniProtKB/TrEMBL
    A0A9L0R3K2, A0A9L0R8G2
    Related
    ENSECAP00000059137.1, ENSECAT00000096067.1
    Conserved Domains (1) summary
    cd02058
    Location:27 → 402
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

  2. XM_005603500.3 → XP_005603557.1  leukocyte elastase inhibitor isoform X2

    See identical proteins and their annotated locations for XP_005603557.1

    UniProtKB/Swiss-Prot
    P05619
    UniProtKB/TrEMBL
    K9K3A1
    Conserved Domains (1) summary
    cd02058
    Location:4 → 379
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

  3. XM_005603499.3 → XP_005603556.1  leukocyte elastase inhibitor isoform X2

    See identical proteins and their annotated locations for XP_005603556.1

    UniProtKB/Swiss-Prot
    P05619
    UniProtKB/TrEMBL
    K9K3A1
    Conserved Domains (1) summary
    cd02058
    Location:4 → 379
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05619.3 GenPept UniProtKB/Swiss-Prot:P05619

Gene LinkOut

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