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SCN8A sodium voltage-gated channel alpha subunit 8 [ Equus caballus (horse) ]

Gene ID: 100052777, updated on 8-Mar-2024

Summary

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Official Symbol
SCN8Aprovided by VGNC
Official Full Name
sodium voltage-gated channel alpha subunit 8provided by VGNC
Primary source
VGNC:VGNC:22742
See related
Ensembl:ENSECAG00000010751
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See SCN8A in Genome Data Viewer
Location:
chromosome: 6
Exon count:
31
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 6 NC_009149.3 (69728192..69904503)
102 previous assembly EquCab2.0 (GCF_000002305.2) 6 NC_009149.2 (68827616..69003399)

Chromosome 6 - NC_009149.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106783321 Neighboring gene solute carrier family 4 member 8 Neighboring gene fidgetin like 2 Neighboring gene ankyrin repeat domain 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane depolarization during action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated sodium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium channel protein type 8 subunit alpha
Names
sodium channel, voltage gated, type VIII, alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009149.3 Reference EquCab3.0 Primary Assembly

    Range
    69728192..69904503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023643583.1 → XP_023499351.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2HNY5
    Conserved Domains (6) summary
    smart00015
    Location:1905 → 1926
    IQ; Calmodulin-binding motif
    cd13433
    Location:1476 → 1528
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1208 → 1484
    Ion_trans; Ion transport protein
    pfam06512
    Location:1002 → 1203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 699
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1791 → 1854
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. XM_023643584.1 → XP_023499352.1  sodium channel protein type 8 subunit alpha isoform X2

    UniProtKB/TrEMBL
    F7AP65
    Conserved Domains (6) summary
    smart00015
    Location:1905 → 1926
    IQ; Calmodulin-binding motif
    cd13433
    Location:1476 → 1528
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1208 → 1484
    Ion_trans; Ion transport protein
    pfam06512
    Location:1002 → 1203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 699
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1791 → 1854
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. XM_023643586.1 → XP_023499354.1  sodium channel protein type 8 subunit alpha isoform X4

    UniProtKB/TrEMBL
    F7AP65
    Related
    ENSECAP00000009539.4, ENSECAT00000012112.4
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 688
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1843
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. XM_023643588.1 → XP_023499356.1  sodium channel protein type 8 subunit alpha isoform X6

    UniProtKB/TrEMBL
    F7AP65
    Conserved Domains (6) summary
    smart00015
    Location:1853 → 1874
    IQ; Calmodulin-binding motif
    cd13433
    Location:1424 → 1476
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1481 → 1735
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 688
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1739 → 1802
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. XM_023643582.1 → XP_023499350.1  sodium channel protein type 8 subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A3Q2HNY5
    Conserved Domains (6) summary
    smart00015
    Location:1905 → 1926
    IQ; Calmodulin-binding motif
    cd13433
    Location:1476 → 1528
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1208 → 1484
    Ion_trans; Ion transport protein
    pfam06512
    Location:1002 → 1203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 699
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1791 → 1854
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. XM_023643587.1 → XP_023499355.1  sodium channel protein type 8 subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A3Q2HNY5
    Conserved Domains (6) summary
    smart00015
    Location:1864 → 1885
    IQ; Calmodulin-binding motif
    cd13433
    Location:1435 → 1487
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1492 → 1746
    Ion_trans; Ion transport protein
    pfam06512
    Location:1002 → 1203
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 699
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1750 → 1813
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. XM_023643585.1 → XP_023499353.1  sodium channel protein type 8 subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A3Q2HNY5
    Related
    ENSECAP00000035730.3, ENSECAT00000052309.3
    Conserved Domains (6) summary
    smart00015
    Location:1894 → 1915
    IQ; Calmodulin-binding motif
    cd13433
    Location:1465 → 1517
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1197 → 1473
    Ion_trans; Ion transport protein
    pfam06512
    Location:991 → 1192
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:502 → 688
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1780 → 1843
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. XM_023643590.1 → XP_023499358.1  sodium channel protein type 8 subunit alpha isoform X7

    UniProtKB/TrEMBL
    F7AIR2
    Related
    ENSECAP00000009590.4, ENSECAT00000012166.4
    Conserved Domains (6) summary
    smart00015
    Location:1743 → 1764
    IQ; Calmodulin-binding motif
    cd13433
    Location:1314 → 1366
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:1046 → 1322
    Ion_trans; Ion transport protein
    pfam06512
    Location:840 → 1041
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:340 → 537
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1629 → 1692
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. XM_023643592.1 → XP_023499360.1  sodium channel protein type 8 subunit alpha isoform X8

    UniProtKB/TrEMBL
    F7AIR2
    Conserved Domains (6) summary
    smart00015
    Location:1651 → 1672
    IQ; Calmodulin-binding motif
    cd13433
    Location:1222 → 1274
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:954 → 1230
    Ion_trans; Ion transport protein
    pfam06512
    Location:748 → 949
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:248 → 445
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1537 → 1600
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. XM_023643591.1 → XP_023499359.1  sodium channel protein type 8 subunit alpha isoform X8

    UniProtKB/TrEMBL
    F7AIR2
    Conserved Domains (6) summary
    smart00015
    Location:1651 → 1672
    IQ; Calmodulin-binding motif
    cd13433
    Location:1222 → 1274
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:954 → 1230
    Ion_trans; Ion transport protein
    pfam06512
    Location:748 → 949
    Na_trans_assoc; Sodium ion transport-associated
    pfam11933
    Location:248 → 445
    Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
    pfam16905
    Location:1537 → 1600
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  11. XM_023643593.1 → XP_023499361.1  sodium channel protein type 8 subunit alpha isoform X9

    Conserved Domains (5) summary
    smart00015
    Location:1210 → 1231
    IQ; Calmodulin-binding motif
    cd13433
    Location:781 → 833
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:513 → 789
    Ion_trans; Ion transport protein
    pfam06512
    Location:307 → 508
    Na_trans_assoc; Sodium ion transport-associated
    pfam16905
    Location:1096 → 1159
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RNA

  1. XR_002808760.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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