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SNHG8 small nucleolar RNA host gene 8 [ Homo sapiens (human) ]

Gene ID: 100093630, updated on 17-Mar-2024

Summary

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Official Symbol
SNHG8provided by HGNC
Official Full Name
small nucleolar RNA host gene 8provided by HGNC
Primary source
HGNC:HGNC:33098
See related
Ensembl:ENSG00000269893 AllianceGenome:HGNC:33098
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC00060; NCRNA00060
Expression
Ubiquitous expression in ovary (RPKM 73.3), prostate (RPKM 50.6) and 25 other tissues See more
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Genomic context

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Location:
4q26
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (118278762..118279823)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (121583738..121584799)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (119199917..119200978)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986307 Neighboring gene N-deacetylase and N-sulfotransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119115072-119115572 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119115573-119116073 Neighboring gene FKBP prolyl isomerase 4 pseudogene 1 Neighboring gene uncharacterized LOC105377392 Neighboring gene uncharacterized LOC124900765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15649 Neighboring gene uncharacterized LOC124900766 Neighboring gene small nucleolar RNA, H/ACA box 24 Neighboring gene serine protease 12 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:119273903-119274748 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:119318395-119319594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21846 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A review on the role of SNHG8 in human disorders. Ghafouri-Fard S, et al. Pathol Res Pract, 2023 May. PMID 37043963
  2. [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer]. Cheng Z, et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2023 Feb 25. PMID 36854552, Free PMC Article
  3. Differentiated expression of long non-coding RNA-small nucleolar RNA host gene 8 in atherosclerosis and its molecular mechanism. Wang S, et al. Bioengineered, 2021 Dec. PMID 34558393, Free PMC Article
  4. Small nucleolar RNA host gene 8: A rising star in the targets for cancer therapy. Yuan X, et al. Biomed Pharmacother, 2021 Jul. PMID 33894626
  5. Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7. Shi Z, et al. J Gene Med, 2021 Mar. PMID 33450101

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
    Title: Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
  2. The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
    Title: The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
  3. LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK1/2 signaling axis.
    Title: LncRNA SNHG8 regulates the migration and angiogenesis of pHUVECs induced by high glucose via the TRPM7/ERK(1/2) signaling axis.
  4. A review on the role of SNHG8 in human disorders.
    Title: A review on the role of SNHG8 in human disorders.
  5. [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer].
    Title: [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer].
  6. Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
    Title: Long noncoding RNA SNHG8 promotes chemoresistance in gastric cancer via binding with hnRNPA1 and stabilizing TROY expression.
  7. YY1-induced long non-coding RNA small nucleolar RNA host gene 8 promotes the tumorigenesis of melanoma via the microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis.
    Title: YY1-induced long non-coding RNA small nucleolar RNA host gene 8 promotes the tumorigenesis of melanoma via the microRNA-656-3p/SERPINE1 mRNA binding protein 1 axis.
  8. SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis.
    Title: SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis.
  9. Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis.
    Title: Knockdown of long non-coding RNA SNHG8 suppresses the progression of esophageal cancer by regulating miR-1270/BACH1 axis.
  10. Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.
    Title: Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • long intergenic non-protein coding RNA 60
  • small nucleolar RNA host gene (non-protein coding) 8
  • small nucleolar RNA host gene 8 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_003584.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC039555, CF124302

  2. NR_034010.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment compared to variant 1.
    Source sequence(s)
    BC039555, BM845860
    Related
    ENST00000688996.1

  3. NR_034011.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment compared to variant 1.
    Source sequence(s)
    BC039555, CD520851
    Related
    ENST00000602520.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    118278762..118279823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    121583738..121584799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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