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SYCE1L synaptonemal complex central element protein 1 like [ Homo sapiens (human) ]

Gene ID: 100130958, updated on 7-Apr-2024

Summary

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Official Symbol
SYCE1Lprovided by HGNC
Official Full Name
synaptonemal complex central element protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:37236
See related
Ensembl:ENSG00000205078 MIM:619954; AllianceGenome:HGNC:37236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP2
Summary
Predicted to be involved in synaptonemal complex assembly. Located in intermediate filament cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 20.9), urinary bladder (RPKM 20.3) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16q23.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (77199408..77213215)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (83255583..83269389)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (77233305..77247112)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903724 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44883 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:77098253-77098456 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:77113401-77113619 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44931 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_44984 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45056 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45073 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45133 Neighboring gene MPRA-validated peak2646 silencer Neighboring gene uncharacterized LOC124903725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:77224805-77225753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45171 Neighboring gene uncharacterized LOC124903726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:77246135-77247108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11151 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_45205 Neighboring gene MON1 homolog B, secretory trafficking associated Neighboring gene vomeronasal 2 receptor 10, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:77322970-77324169 Neighboring gene uncharacterized LOC124903727 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a new transcript specifically expressed in mouse spermatocytes: mmrp2. Gu S, et al. Mol Biol Rep, 2005 Dec. PMID 16328886
  2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in synaptonemal complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
synaptonemal complex central element protein 1-like
Names
meiosis-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129979.3 → NP_001123451.1  synaptonemal complex central element protein 1-like isoform 1

    See identical proteins and their annotated locations for NP_001123451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC009139
    Consensus CDS
    CCDS45533.1
    UniProtKB/Swiss-Prot
    A6NF23, A8MT33
    Related
    ENSP00000367911.4, ENST00000378644.5
    Conserved Domains (1) summary
    pfam15233
    Location:47 → 164
    SYCE1; Synaptonemal complex central element protein 1

  2. NM_001348924.2 → NP_001335853.1  synaptonemal complex central element protein 1-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC009139
    Conserved Domains (1) summary
    pfam15233
    Location:47 → 123
    SYCE1; Synaptonemal complex central element protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    77199408..77213215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    83255583..83269389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MT33.3 GenPept UniProtKB/Swiss-Prot:A8MT33

Gene LinkOut

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