CD24 CD24 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD24provided by HGNC
Official Full Name: CD24 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1645
See related: Ensembl:ENSG00000272398 MIM:600074; AllianceGenome:HGNC:1645
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD24A
Summary: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression: Biased expression in thyroid (RPKM 586.8), esophagus (RPKM 431.3) and 12 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (106969831..106976855, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (108145896..108152920, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6 (PATCHES)	NW_004504300.1 (274454..281478, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS.
Title: The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS.
Checkpoint CD24 function on tumor and immunotherapy.
Title: Checkpoint CD24 function on tumor and immunotherapy.
CD24 blockade promotes anti-tumor immunity in oral squamous cell carcinoma.
Title: CD24 blockade promotes anti-tumor immunity in oral squamous cell carcinoma.
Surprising magic of CD24 beyond cancer.
Title: Surprising magic of CD24 beyond cancer.
High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
Title: High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
RARgamma promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
Title: RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.
CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners.
Title: CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners.
Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200.
Title: Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200.
Soluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis.
Title: Soluble CD24 is an inflammatory biomarker in early and seronegative rheumatoid arthritis.
Prognostic Implications of CD24, SOX2, and Nanog Expression in Invasive Urothelial Carcinoma.
Title: Prognostic Implications of CD24, SOX2, and Nanog Expression in Invasive Urothelial Carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (286)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CD24_1314 (e-PCR)
- UniSTS:277071

RH15606 (e-PCR)
- UniSTS:90195

RH66795 (e-PCR)
- UniSTS:48497

RH70313 (e-PCR)
- UniSTS:91262

GDB:384220 (e-PCR)
- UniSTS:157080

GDB:384235 (e-PCR)
- UniSTS:157082

GDB:384236 (e-PCR)
- UniSTS:157083

sY3210 (e-PCR)
- UniSTS:515250

sY3211 (e-PCR)
- UniSTS:515251

GDB:585571 (e-PCR)
- UniSTS:157891

PMC95860P1 (e-PCR)
- UniSTS:273624

DYS415 (e-PCR)
- UniSTS:75737

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor transport into membrane raft	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in chemokine receptor transport out of membrane raft	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in glomerular parietal epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response-regulating cell surface receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta3 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in podocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nephron tubule epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of epithelial cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in respiratory burst	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to molecule of bacterial origin	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal transducer CD24

Names: CD24 antigen (small cell lung carcinoma cluster 4 antigen)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_041768.1 RefSeqGene

Range

7127..12025

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001291737.1 → NP_001278666.1 signal transducer CD24 isoform a preproprotein

See identical proteins and their annotated locations for NP_001278666.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.

Source sequence(s)

AK026603, AK125531, AU125939, BU580553, DA753855

Consensus CDS

CCDS75499.1

UniProtKB/Swiss-Prot

A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5

Related

ENSP00000483838.1, ENST00000610952.1

Conserved Domains (1) summary

pfam14984
Location:47 → 79

CD24; CD24 protein
NM_001291738.1 → NP_001278667.1 signal transducer CD24 isoform a preproprotein

See identical proteins and their annotated locations for NP_001278667.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.

Source sequence(s)

AK026603, AK125531, BU580553, DA378105

Consensus CDS

CCDS75499.1

UniProtKB/Swiss-Prot

A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5

Conserved Domains (1) summary

pfam14984
Location:47 → 79

CD24; CD24 protein
NM_001291739.1 → NP_001278668.1 signal transducer CD24 isoform b

See identical proteins and their annotated locations for NP_001278668.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.

Source sequence(s)

AK026603, AK125531, BU580553, DA518957

Consensus CDS

CCDS78166.1

UniProtKB/TrEMBL

A0A087WYI6

Related

ENSP00000481841.1, ENST00000622315.1

Conserved Domains (1) summary

pfam14984
Location:96 → 128

CD24; CD24 protein
NM_001359084.1 → NP_001346013.1 signal transducer CD24 isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.

Source sequence(s)

AK026603, DA521039, FP885534

Consensus CDS

CCDS75499.1

UniProtKB/Swiss-Prot

A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5

Related

ENSP00000475625.1, ENST00000606017.2

Conserved Domains (1) summary

pfam14984
Location:47 → 79

CD24; CD24 protein
NM_013230.3 → NP_037362.1 signal transducer CD24 isoform a preproprotein

See identical proteins and their annotated locations for NP_037362.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 7 encode isoform a.

Source sequence(s)

AK026603, AK125531, BG755979, BU580553

Consensus CDS

CCDS75499.1

UniProtKB/Swiss-Prot

A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5

Related

ENSP00000483985.1, ENST00000619133.4

Conserved Domains (1) summary

pfam14984
Location:47 → 79

CD24; CD24 protein

RNA

NR_117089.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks the internal exon and contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AK026603, AK125531, AU125939, BU580553, DA745135
NR_117090.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks the internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.

Source sequence(s)

AK026603, AK125531, BG755979, BU580553, DA253943