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PDGFB platelet derived growth factor subunit B [ Felis catus (domestic cat) ]

Gene ID: 100135774, updated on 8-Mar-2024

Summary

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Official Symbol
PDGFB
Official Full Name
platelet derived growth factor subunit B
Primary source
VGNC:VGNC:68770
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as
SIS; cis; PDGF; PDGF-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: B4
Exon count:
8
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (132623202..132642427, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (134970139..134989320, complement)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123386846 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene uncharacterized LOC109501804 Neighboring gene uncharacterized LOC102900613 Neighboring gene uncharacterized LOC109501805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
platelet-derived growth factor subunit B
Names
PDGF subunit B
Platelet-derived growth factor B chain
Platelet-derived growth factor subunit B
Proto-oncogene c-Sis
c-sis proto oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    132623202..132642427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003989270.6 → XP_003989319.1  platelet-derived growth factor subunit B isoform X4

    UniProtKB/Swiss-Prot
    P12919
    Conserved Domains (2) summary
    pfam00341
    Location:97 → 180
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:21 → 93
    PDGF_N; Platelet-derived growth factor, N terminal region

  2. XM_006934050.5 → XP_006934112.1  platelet-derived growth factor subunit B isoform X3

    UniProtKB/Swiss-Prot
    P12919
    UniProtKB/TrEMBL
    W5LV43
    Conserved Domains (2) summary
    pfam00341
    Location:101 → 184
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:21 → 86
    PDGF_N; Platelet-derived growth factor, N terminal region

  3. XM_045062386.1 → XP_044918321.1  platelet-derived growth factor subunit B isoform X2

    UniProtKB/Swiss-Prot
    P12919
    Conserved Domains (1) summary
    smart00141
    Location:100 → 187
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

  4. XM_045062385.1 → XP_044918320.1  platelet-derived growth factor subunit B isoform X1

    UniProtKB/Swiss-Prot
    P12919
    Conserved Domains (1) summary
    smart00141
    Location:104 → 191
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

  5. XM_045062384.1 → XP_044918319.1  platelet-derived growth factor subunit B isoform X1

    UniProtKB/Swiss-Prot
    P12919
    Conserved Domains (1) summary
    smart00141
    Location:104 → 191
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12919.1 GenPept UniProtKB/Swiss-Prot:P12919

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