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CFTR CF transmembrane conductance regulator [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100137035, updated on 26-Mar-2024

Summary

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Gene symbol
CFTR
Gene description
CF transmembrane conductance regulator
Locus tag
CR201_G0026284
See related
Ensembl:ENSPPYG00000017940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Also known as
ABCC7
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 6 NC_071991.2 (114617808..114812268)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 7 NC_071992.1 (108440359..108634819)

Chromosome 6 - NC_071991.2Genomic Context describing neighboring genes Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene uncharacterized LOC134761786 Neighboring gene ankyrin repeat domain-containing protein 49-like Neighboring gene uncharacterized LOC112134324 Neighboring gene cortactin binding protein 2 Neighboring gene uncharacterized LOC129060270

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potentially lethal cystic fibrosis gene variant in the orangutan. Taylor-Cousar JL, et al. Am J Primatol, 2021 Dec. PMID 31967360

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Potentially lethal cystic fibrosis gene variant in the orangutan.
    Title: Potentially lethal cystic fibrosis gene variant in the orangutan.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cystic fibrosis transmembrane conductance regulator
Names
ATP-binding cassette sub-family C member 7
ATP-binding cassette transporter sub-family C member 7
cAMP-dependent chloride channel
channel conductance-controlling ATPase
cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
NP_001162017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168545.1 → NP_001162017.1  cystic fibrosis transmembrane conductance regulator

    See identical proteins and their annotated locations for NP_001162017.1

    Status: PROVISIONAL

    Source sequence(s)
    DP000026
    UniProtKB/Swiss-Prot
    Q2IBE4
    UniProtKB/TrEMBL
    A0A2J8UPC3
    Related
    ENSPPYP00000020117.2, ENSPPYT00000020909.2
    Conserved Domains (5) summary
    cd03289
    Location:1208 → 1480
    ABCC_CFTR2; ATP-binding cassette domain 2 of CFTR,subfamily C
    cd03291
    Location:389 → 670
    ABCC_CFTR1; ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C
    TIGR01271
    Location:1 → 1480
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:866 → 1147
    ABC_membrane; ABC transporter transmembrane region
    pfam14396
    Location:639 → 849
    CFTR_R; Cystic fibrosis TM conductance regulator (CFTR), regulator domain

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071991.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    114617808..114812268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2IBE4.1 GenPept UniProtKB/Swiss-Prot:Q2IBE4

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