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kiss1 KiSS-1 metastasis suppressor [ Oryzias latipes (Japanese medaka) ]

Gene ID: 100144371, updated on 8-Mar-2024

Summary

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Gene symbol
kiss1
Gene description
KiSS-1 metastasis suppressor
See related
EnsemblRapid:ENSORLG00000025285
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
kiss-1
Orthologs
zebrafish all
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Genomic context

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Location:
chromosome: 5
Exon count:
4
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 5 NC_019863.2 (20239862..20248113, complement)
102 previous assembly ASM31367v1 (GCF_000313675.1) 5 NC_019863.1 (19287008..19296008, complement)

Chromosome 5 - NC_019863.2Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 11 Neighboring gene pleckstrin homology domain containing, family A member 6 Neighboring gene golgi transport 1A Neighboring gene dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like Neighboring gene golgin subfamily A member 6-like protein 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of kisspeptin1 on electrical activity of an extrahypothalamic population of gonadotropin-releasing hormone neurons in medaka (Oryzias latipes). Zhao Y, et al. PLoS One, 2012. PMID 22649563, Free PMC Article
  2. Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Kanda S, et al. Endocrinology, 2008 May. PMID 18202129
  3. Expression and putative function of kisspeptins and their receptors during early development in medaka. Hodne K, et al. Endocrinology, 2013 Sep. PMID 23825126
  4. Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study. Nakajo M, et al. Endocrinology, 2018 Jan 1. PMID 29053844
  5. Social rank-dependent expression of gonadotropin-releasing hormones and kisspeptin in the medaka brain. Kagawa N, et al. Gen Comp Endocrinol, 2017 Aug 1. PMID 28279673

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data (including data from studies in transgenic/knockout fish) suggest that neuronal kiss-1, kiss-2, and gpr54-1 are key factors of nonreproductive regulation in teleosts as in mammals; here, genetically labeled kiss/kiss receptor-expressing neurons in ventrolateral preoptic area appear to control hypothalamic-pituitary-gonadal axis. (kiss = kisspeptin; gpr54-1= kisspeptin receptor-1)
    Title: Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study.
  2. These results suggest that social hierarchy regulates the expression of GnRH1, GnRH3, and Kiss1 without affecting 11-ketotestosterone level in male medaka.
    Title: Social rank-dependent expression of gonadotropin-releasing hormones and kisspeptin in the medaka brain.
  3. Data suggest that kiss-1 and kiss-1 receptors (gpr54-1; gpr54-2) are involved in morphogenesis of medaka zygotes; knockdown of kiss-1 and gpr54-1 disrupts gastrulation; knockdown of kiss-1, gpr54-1, and gpr54-2 disrupts neurulation.
    Title: Expression and putative function of kisspeptins and their receptors during early development in medaka.
  4. Kiss1 stimulated TN-GnRH3 neurons in a narrow dose range (100-500 nM), while relatively high doses kiss1(10) (1000 and 10,000 nM) were ineffective in altering the electrical activity of TN-GnRH3 neurons
    Title: Effects of kisspeptin1 on electrical activity of an extrahypothalamic population of gonadotropin-releasing hormone neurons in medaka (Oryzias latipes).
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
metastasis-suppressor KiSS-1; metastin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122921.1 → NP_001116393.1  metastasis-suppressor KiSS-1 precursor

    See identical proteins and their annotated locations for NP_001116393.1

    Status: PROVISIONAL

    Source sequence(s)
    AB272755
    UniProtKB/TrEMBL
    A0A3P9K4A5, A9ZMG6
    Related
    ENSORLP00000030294.1, ENSORLT00000040678.2
    Conserved Domains (1) summary
    pfam15152
    Location:78 → 99
    Kisspeptin; Kisspeptin

RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019863.2 Reference ASM223467v1 Primary Assembly

    Range
    20239862..20248113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023954650.1 → XP_023810418.1  metastin isoform X1

    UniProtKB/TrEMBL
    A0A3B3HEH2, A0A3P9K4A5
    Conserved Domains (1) summary
    pfam15152
    Location:47 → 99
    Kisspeptin

  2. XM_023954649.1 → XP_023810417.1  metastin isoform X1

    UniProtKB/TrEMBL
    A0A3B3HEH2, A0A3P9K4A5
    Conserved Domains (1) summary
    pfam15152
    Location:47 → 99
    Kisspeptin
Nucleotide Protein
Heading Accession and Version

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