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KLLN killin, p53 regulated DNA replication inhibitor [ Homo sapiens (human) ]

Gene ID: 100144748, updated on 11-Jun-2021

Summary

Official Symbol
KLLNprovided by HGNC
Official Full Name
killin, p53 regulated DNA replication inhibitorprovided by HGNC
Primary source
HGNC:HGNC:37212
See related
Ensembl:ENSG00000227268 MIM:612105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWS4; KILLIN
Summary
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
Orthologs
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Genomic context

See KLLN in Genome Data Viewer
Location:
10q23.31
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (87859158..87863533, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89618915..89623290, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene ATPase family AAA domain containing 1 Neighboring gene cofilin 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 78, pseudogene Neighboring gene uncharacterized LOC107987150 Neighboring gene phosphatase and tensin homolog Neighboring gene ribosomal protein L11 pseudogene 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033079.1 RefSeqGene

    Range
    4905..9280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1087

mRNA and Protein(s)

  1. NM_001126049.2NP_001119521.1  killin

    See identical proteins and their annotated locations for NP_001119521.1

    Status: REVIEWED

    Source sequence(s)
    AC063965
    Consensus CDS
    CCDS44454.1
    UniProtKB/Swiss-Prot
    B2CW77
    Related
    ENSP00000392204.2, ENST00000445946.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    87859158..87863533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_013171807.1 Reference GRCh38.p13 PATCHES

    Range
    74981..79357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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