traf1 TNF receptor-associated factor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: traf1provided by ZNC
Official Full Name: TNF receptor-associated factor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-071120-4
See related: Ensembl:ENSDARG00000069482 AllianceGenome:ZFIN:ZDB-GENE-071120-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable tumor necrosis factor receptor binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; regulation of intracellular signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Predicted to be located in cytoplasm. Predicted to be active in cytoplasmic side of plasma membrane. Orthologous to human TRAF1 (TNF receptor associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (12408840..12432685, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (12371135..12394980, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF receptor-associated factor 1

NP_001121853.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128381.1 → NP_001121853.1 TNF receptor-associated factor 1

Status: PROVISIONAL

Source sequence(s)

CR376844

UniProtKB/TrEMBL

A0A8N7UZ20, B0UXK1

Related

ENSDARP00000091948.4, ENSDART00000101174.6

Conserved Domains (3) summary

cd03779
Location:402 → 548

MATH_TRAF1; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF1 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...

pfam02176
Location:134 → 188

zf-TRAF; TRAF-type zinc finger

pfam16673
Location:320 → 375

TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain