Akna AT-hook transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aknaprovided by MGI
Official Full Name: AT-hook transcription factorprovided by MGI
Primary source: MGI:MGI:2140340
See related: Ensembl:ENSMUSG00000039158 AllianceGenome:MGI:2140340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 37.5), thymus adult (RPKM 21.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.96 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63285364..63328988, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63367123..63411094, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death
Title: Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

AI597013 (e-PCR)
- UniSTS:179015

Akna (e-PCR), detects polymorphism
- UniSTS:547181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in delamination	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial to mesenchymal transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast delamination	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuroblast delamination	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroblast division in subventricular zone	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuroblast division in subventricular zone	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microtubule organization protein AKNA

Names: AT-hook-containing transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045514.4 → NP_001038979.1 microtubule organization protein AKNA isoform 1

See identical proteins and their annotated locations for NP_001038979.1

Status: VALIDATED

Source sequence(s)

AL683828

Consensus CDS

CCDS38777.1

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

Related

ENSMUSP00000041614.5, ENSMUST00000035724.5

Conserved Domains (1) summary

pfam12443
Location:584 → 681

AKNA; AT-hook-containing transcription factor
NM_001305432.2 → NP_001292361.1 microtubule organization protein AKNA isoform 1

See identical proteins and their annotated locations for NP_001292361.1

Status: VALIDATED

Source sequence(s)

AL683828

Consensus CDS

CCDS38777.1

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

Conserved Domains (1) summary

pfam12443
Location:584 → 681

AKNA; AT-hook-containing transcription factor
NM_001426143.1 → NP_001413072.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426144.1 → NP_001413073.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426145.1 → NP_001413074.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426146.1 → NP_001413075.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426147.1 → NP_001413076.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426148.1 → NP_001413077.1 microtubule organization protein AKNA isoform 1

Status: VALIDATED

Source sequence(s)

AL683828

UniProtKB/Swiss-Prot

Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
NM_001426149.1 → NP_001413078.1 microtubule organization protein AKNA isoform 2

Status: VALIDATED

Source sequence(s)

AL683828
NM_001426150.1 → NP_001413079.1 microtubule organization protein AKNA isoform 3

Status: VALIDATED

Source sequence(s)

AL683828
NM_001426151.1 → NP_001413080.1 microtubule organization protein AKNA isoform 4

Status: VALIDATED

Source sequence(s)

AL683828

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

63285364..63328988 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163542.1 → XP_036019435.1 microtubule organization protein AKNA isoform X2

Conserved Domains (1) summary

pfam12443
Location:584 → 681

AKNA; AT-hook-containing transcription factor
XM_036163544.1 → XP_036019437.1 microtubule organization protein AKNA isoform X3

Conserved Domains (1) summary

pfam12443
Location:584 → 681

AKNA; AT-hook-containing transcription factor
XM_036163543.1 → XP_036019436.1 microtubule organization protein AKNA isoform X3

Conserved Domains (1) summary

pfam12443
Location:584 → 681

AKNA; AT-hook-containing transcription factor