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NPIPA5 nuclear pore complex interacting protein family member A5 [ Homo sapiens (human) ]

Gene ID: 100288332, updated on 11-Jun-2021

Summary

Official Symbol
NPIPA5provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member A5provided by HGNC
Primary source
HGNC:HGNC:41980
See related
Ensembl:ENSG00000183793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP
Expression
Ubiquitous expression in skin (RPKM 40.1), ovary (RPKM 32.3) and 25 other tissues See more
Orthologs
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Genomic context

See NPIPA5 in Genome Data Viewer
Location:
16p13.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (15363613..15381467, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15457481..15472151, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371097 Neighboring gene uncharacterized LOC107987241 Neighboring gene uncharacterized LOC105371103 Neighboring gene MPV17 mitochondrial inner membrane protein like Neighboring gene bMERB domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 1380

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear pore complex-interacting protein family member A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054723.1 RefSeqGene

    Range
    8185..22851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001277325.2NP_001264254.1  nuclear pore complex-interacting protein family member A5 isoform 1

    See identical proteins and their annotated locations for NP_001264254.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC137803, CB123100, EL734608
    Consensus CDS
    CCDS59264.1
    UniProtKB/Swiss-Prot
    E9PKD4
    Related
    ENSP00000433597.1, ENST00000360151.9
    Conserved Domains (1) summary
    pfam06409
    Location:22306
    NPIP; Nuclear pore complex interacting protein (NPIP)
  2. NM_001351200.1NP_001338129.1  nuclear pore complex-interacting protein family member A5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA770415, AC137803, CB053644, EL734608, KF175171, KF175172
    Consensus CDS
    CCDS86506.1
    Related
    ENSP00000441072.1, ENST00000543801.5
    Conserved Domains (1) summary
    pfam06409
    Location:22214
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    15363613..15381467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450132.1XP_024305900.1  nuclear pore complex-interacting protein family member A5 isoform X1

    Conserved Domains (2) summary
    pfam06409
    Location:41240
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
  2. XM_011522336.3XP_011520638.1  nuclear pore complex-interacting protein family member A5 isoform X3

    Conserved Domains (2) summary
    pfam06409
    Location:70262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
  3. XM_011522329.3XP_011520631.1  nuclear pore complex-interacting protein family member A5 isoform X2

    See identical proteins and their annotated locations for XP_011520631.1

    Related
    ENSP00000435611.1, ENST00000534094.1
    Conserved Domains (2) summary
    pfam06409
    Location:70325
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:141
    AFD_class_I; Adenylate forming domain, Class I superfamily
  4. XM_011522337.1XP_011520639.1  nuclear pore complex-interacting protein family member A5 isoform X4

    Conserved Domains (1) summary
    pfam06409
    Location:26245
    NPIP; Nuclear pore complex interacting protein (NPIP)

RNA

  1. XR_932754.3 RNA Sequence

  2. XR_002957772.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1021570..1036245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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