MIR1244-1 microRNA 1244-1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1244-1provided by HGNC
Official Full Name: microRNA 1244-1provided by HGNC
Primary source: HGNC:HGNC:35310
See related: Ensembl:ENSG00000284378 miRBase:MI0006379; AllianceGenome:HGNC:35310
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIR1244; MIRN1244; hsa-mir-1244; hsa-mir-1244-1
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Annotation information: Note: MIR1244-1 (GeneID 100302285) was annotated incorrectly on NCBI's Annotation Release 105. Its correct location is chr12: 9392063-9392147 (-). [17 Jun 2014]
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Genomic context

Location:: 2q37.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (231713314..231713398)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (232197884..232197968)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (232578024..232578108)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.
Title: RBM4 regulates cellular senescence via miR1244/SERPINE1 axis.
Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis.
Title: Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis.
Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer.
Title: Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer.
MiR-1244 directly targets MDM2 in osteosarcoma.
Title: CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression.
study shows that LINC00504 promotes Ovarian cancer (OC) cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment.
Title: Long non-coding RNA LINC00504 regulates the Warburg effect in ovarian cancer through inhibition of miR-1244.
In summary, we found that miR-1244 affected cisplatin-treated non-small cell lung cancer via MEF2D expression.
Title: Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.