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TMED7-TICAM2 TMED7-TICAM2 readthrough [ Homo sapiens (human) ]

Gene ID: 100302736, updated on 8-Mar-2024

Summary

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Official Symbol
TMED7-TICAM2provided by HGNC
Official Full Name
TMED7-TICAM2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33945
See related
Ensembl:ENSG00000251201 AllianceGenome:HGNC:33945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIRP; TRAM; TICAM2; TIRAP3; MyD88-4; TICAM-2
Summary
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in endometrium (RPKM 26.4), prostate (RPKM 21.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
5q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115578496..115626036, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116091278..116138818, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114914193..114961733, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene fem-1 homolog C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16252 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114937526-114938048 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22936 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC102467217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:115010104-115010604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:115010605-115011105 Neighboring gene uncharacterized LOC124901048

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Palsson-McDermott EM, et al. Nat Immunol, 2009 Jun. PMID 19412184
  2. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. Bin LH, et al. J Biol Chem, 2003 Jul 4. PMID 12721283
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  4. The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2. Li B, et al. Theranostics, 2022. PMID 36168628, Free PMC Article
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90737

General protein information

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Preferred Names
TRAM adaptor with GOLD domain
Names
Putative NF-kappa-B-activating protein 502
TIR domain-containing adapter molecule 2
TMED7-TICAM2 read-through transcript
Toll-like receptor adaptor protein 3
Toll/interleukin-1 receptor domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164468.4 → NP_001157940.1  TRAM adaptor with GOLD domain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1), also known as TAG. This isoform shares sequence identity with the products of both the TMED7 and TICAM2 genes.
    Source sequence(s)
    AC010226, AY304584
    UniProtKB/Swiss-Prot
    Q86XR7
    Related
    ENSP00000282382.4, ENST00000282382.8
    Conserved Domains (2) summary
    pfam01105
    Location:36 → 189
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    cl23749
    Location:250 → 341
    TIR_2; TIR domain

  2. NM_001164469.4 → NP_001157941.1  TRAM adaptor with GOLD domain isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that causes an early stop codon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus and shares no sequence identity with the downstream TICAM2 gene product, compared to isoform 1.
    Source sequence(s)
    AC010226, AY304583
    UniProtKB/TrEMBL
    A0A0A6YYA0
    Related
    ENSP00000333650.3, ENST00000333314.3
    Conserved Domains (1) summary
    pfam01105
    Location:36 → 188
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115578496..115626036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116091278..116138818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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