pik3c2g phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pik3c2gprovided by ZNC
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-170327-2
See related: AllianceGenome:ZFIN:ZDB-GENE-170327-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:cabz01083482.2
Summary: Predicted to enable kinase activity and phosphatidylinositol binding activity. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; and phosphorylation. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (50921915..50937223)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (50905479..50920580, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

G46565 (e-PCR)
- UniSTS:107366

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

50921915..50937223

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467935.1 → XP_021323610.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2

UniProtKB/TrEMBL

A0A8M9PR53

Conserved Domains (3) summary

cd04012
Location:331 → 487

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:509 → 677

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:683 → 748

PKc_like; Protein Kinases, catalytic domain
XM_021467936.1 → XP_021323611.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X3

UniProtKB/TrEMBL

A0A8M9PMY2

Conserved Domains (3) summary

cd04012
Location:331 → 487

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:509 → 677

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl21453
Location:683 → 748

PKc_like; Protein Kinases, catalytic domain
XM_017352158.2 → XP_017207647.2 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1

UniProtKB/TrEMBL

A0A8M6Z287

Conserved Domains (5) summary

cd04012
Location:331 → 487

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1169 → 1280

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:509 → 677

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02563
Location:1061 → 1140

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:683 → 1036

PKc_like; Protein Kinases, catalytic domain