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tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [ Danio rerio (zebrafish) ]

Gene ID: 100333043, updated on 11-Apr-2024

Summary

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Official Symbol
tap1provided by ZNC
Official Full Name
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-43
See related
Ensembl:ENSDARG00000079766 AllianceGenome:ZFIN:ZDB-GENE-050517-43
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ABC-type peptide transporter activity. Predicted to be involved in peptide transport and transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (48678574..48705831)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (48736649..48763813)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene pre-B-cell leukemia homeobox 2 Neighboring gene notch receptor, like Neighboring gene bromodomain containing 2b Neighboring gene si:ch73-31d8.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Xu H, et al. Int J Mol Sci, 2017 Jul 31. PMID 28758957, Free PMC Article
  2. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. Fleming A, et al. PLoS One, 2013. PMID 24147021, Free PMC Article
  3. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
  4. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. McConnell SC, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27493218, Free PMC Article
  5. B cells in teleost fish act as pivotal initiating APCs in priming adaptive immunity: an evolutionary perspective on the origin of the B-1 cell subset and B7 molecules. Zhu LY, et al. J Immunol, 2014 Mar 15. PMID 24532580

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type peptide transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
antigen peptide transporter 1
Names
abcb2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    48678574..48705831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002665007.3 → XP_002665053.1  antigen peptide transporter 1

    UniProtKB/TrEMBL
    A0A8M1RMC7, E7F8A9
    Related
    ENSDARP00000124923.1, ENSDART00000150156.3
    Conserved Domains (3) summary
    TIGR00958
    Location:42 → 712
    3a01208; Conjugate Transporter-2 (CT2) Family protein
    pfam00664
    Location:166 → 433
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:467 → 692
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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