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ACACA acetyl-CoA carboxylase alpha [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100355970, updated on 3-Apr-2024

Summary

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Gene symbol
ACACA
Gene description
acetyl-CoA carboxylase alpha
See related
Ensembl:ENSOCUG00000014453
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 19 NC_067392.1 (23098620..23415379)

Chromosome 19 - NC_067392.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 14 Neighboring gene uncharacterized LOC103351525 Neighboring gene transcriptional adaptor 2A Neighboring gene chromosome 19 C17orf78 homolog Neighboring gene apoptosis antagonizing transcription factor Neighboring gene uncharacterized LOC127484374 Neighboring gene LIM homeobox 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067392.1 Chromosome 19 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
acetyl-CoA carboxylase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067392.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    23098620..23415379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008271164.3 → XP_008269386.1  acetyl-CoA carboxylase 1 isoform X1

    See identical proteins and their annotated locations for XP_008269386.1

    UniProtKB/TrEMBL
    A0A5F9DAT8
    Conserved Domains (8) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

  2. XM_008271162.3 → XP_008269384.1  acetyl-CoA carboxylase 1 isoform X1

    See identical proteins and their annotated locations for XP_008269384.1

    UniProtKB/TrEMBL
    A0A5F9DAT8
    Related
    ENSOCUP00000042755.1
    Conserved Domains (8) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

  3. XM_008271159.3 → XP_008269381.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/TrEMBL
    A0A5F9DAT8, G1T7I3
    Related
    ENSOCUP00000012460.4
    Conserved Domains (8) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:155 → 274
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:790 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1706 → 2254
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:544 → 651
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:857 → 1606
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:316 → 507
    ATP-grasp_4; ATP-grasp domain

  4. XM_051824672.1 → XP_051680632.1  acetyl-CoA carboxylase 1 isoform X1

  5. XM_008271157.3 → XP_008269379.2  acetyl-CoA carboxylase 1 isoform X2

    UniProtKB/TrEMBL
    A0A5F9DAT8

  6. XM_002719077.4 → XP_002719123.2  acetyl-CoA carboxylase 1 isoform X1

    UniProtKB/TrEMBL
    A0A5F9DAT8
    Conserved Domains (8) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

  7. XM_008271161.3 → XP_008269383.1  acetyl-CoA carboxylase 1 isoform X1

    See identical proteins and their annotated locations for XP_008269383.1

    UniProtKB/TrEMBL
    A0A5F9DAT8
    Conserved Domains (8) summary
    COG0439
    Location:118 → 620
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:671 → 818
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00289
    Location:118 → 237
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam00364
    Location:753 → 818
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1669 → 2217
    Carboxyl_trans; Carboxyl transferase domain
    pfam02785
    Location:507 → 614
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam08326
    Location:820 → 1569
    ACC_central; Acetyl-CoA carboxylase, central region
    cl17255
    Location:279 → 470
    ATP-grasp_4; ATP-grasp domain

  8. XM_051824674.1 → XP_051680634.1  acetyl-CoA carboxylase 1 isoform X5

  9. XM_051824673.1 → XP_051680633.1  acetyl-CoA carboxylase 1 isoform X4

Nucleotide Protein
Heading Accession and Version

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