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SOCS4 suppressor of cytokine signaling 4 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100357417, updated on 8-Mar-2024

Summary

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Gene symbol
SOCS4
Gene description
suppressor of cytokine signaling 4
See related
Ensembl:ENSOCUG00000004006
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 17 NC_067390.1 (74531679..74556018)

Chromosome 17 - NC_067390.1Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene uncharacterized LOC103351260 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067390.1 Chromosome 17 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
suppressor of cytokine signaling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067390.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    74531679..74556018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051822875.1 → XP_051678835.1  suppressor of cytokine signaling 4

    UniProtKB/TrEMBL
    G1SKV6

  2. XM_008269682.3 → XP_008267904.1  suppressor of cytokine signaling 4

    UniProtKB/TrEMBL
    G1SKV6
    Related
    ENSOCUP00000003465.1
    Conserved Domains (3) summary
    cd10385
    Location:276 → 376
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:385 → 440
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:59 → 109
    SOCS; Suppressor of cytokine signalling
Nucleotide Protein
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