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Immp2l inner mitochondrial membrane peptidase subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359529, updated on 13-Apr-2024

Summary

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Symbol
Immp2lprovided by RGD
Full Name
inner mitochondrial membrane peptidase subunit 2provided by RGD
Primary source
RGD:2323665
See related
Ensembl:ENSRNOG00000067070 AllianceGenome:RGD:2323665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable peptidase activity. Predicted to act upstream of or within several processes, including cerebellum vasculature development; gamete generation; and mitochondrion organization. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 64.1), Heart (RPKM 57.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (63797189..64696906)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (58070035..58970165)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (60958351..61859457)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093202 Neighboring gene zinc finger protein 277 Neighboring gene dedicator of cytokinesis 4 Neighboring gene uncharacterized LOC102552766 Neighboring gene uncharacterized LOC120093204 Neighboring gene H3.3 histone like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120093203 Neighboring gene leucine rich repeat neuronal 3 Neighboring gene uncharacterized LOC134479121 Neighboring gene uncharacterized LOC120103525 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function. Ma Y, et al. Neurobiol Dis, 2011 Dec. PMID 21824519, Free PMC Article
  2. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Lu B, et al. Biol Reprod, 2008 Apr. PMID 18094351
  3. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
  4. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Burri L, et al. Mol Biol Cell, 2005 Jun. PMID 15814844, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blood circulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellum vasculature development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrial respiratory chain complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ovulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein processing involved in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
  
involved_in signal peptide processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial inner membrane peptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial inner membrane protease subunit 2
Names
IMP2 inner mitochondrial membrane peptidase-like
rCG61688-like
NP_001385633.1
XP_038934060.1
XP_038934061.1
XP_038934062.1
XP_038934063.1
XP_038934065.1
XP_063117436.1
XP_063117437.1
XP_063117438.1
XP_063117439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398704.1 → NP_001385633.1  mitochondrial inner membrane protease subunit 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6A7I6, A6HBE0
    Related
    ENSRNOP00000088187.1, ENSRNOT00000098533.1
    Conserved Domains (1) summary
    cd06530
    Location:36 → 146
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    63797189..64696906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078133.2 → XP_038934061.1  mitochondrial inner membrane protease subunit 2 isoform X1

    Conserved Domains (1) summary
    cd06530
    Location:36 → 99
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

  2. XM_063261368.1 → XP_063117438.1  mitochondrial inner membrane protease subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7I6, A6HBE0

  3. XM_039078135.2 → XP_038934063.1  mitochondrial inner membrane protease subunit 2 isoform X1

    Conserved Domains (1) summary
    cd06530
    Location:36 → 99
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

  4. XM_039078134.2 → XP_038934062.1  mitochondrial inner membrane protease subunit 2 isoform X1

    Conserved Domains (1) summary
    cd06530
    Location:36 → 99
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

  5. XM_039078132.2 → XP_038934060.1  mitochondrial inner membrane protease subunit 2 isoform X1

    Conserved Domains (1) summary
    cd06530
    Location:36 → 99
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

  6. XM_063261369.1 → XP_063117439.1  mitochondrial inner membrane protease subunit 2 isoform X3

  7. XM_039078137.2 → XP_038934065.1  mitochondrial inner membrane protease subunit 2 isoform X1

    Conserved Domains (1) summary
    cd06530
    Location:36 → 99
    S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

  8. XM_063261366.1 → XP_063117436.1  mitochondrial inner membrane protease subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7I6, A6HBE0

  9. XM_063261367.1 → XP_063117437.1  mitochondrial inner membrane protease subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7I6, A6HBE0
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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