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Palld palladin, cytoskeletal associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360205, updated on 24-Jul-2021

Summary

Symbol
Palldprovided by RGD
Full Name
palladin, cytoskeletal associated proteinprovided by RGD
Primary source
RGD:2322545
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Uterus (RPKM 195.1), Heart (RPKM 175.2) and 8 other tissues See more
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Genomic context

See Palld in Genome Data Viewer
Location:
16p12
Exon count:
25
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28228006..28621349)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31865712..31948168)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene palladin-like 1 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC120097508 Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene carbonyl reductase 4 Neighboring gene SH3 domain containing ring finger 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within keratinocyte development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ruffle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trophoblast giant cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
palladin; palladin, cytoskeletal associated protein
Names
palladin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    28228006..28621349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094916.1XP_038950844.1  palladin isoform X3

    Conserved Domains (6) summary
    pfam07679
    Location:449546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:11611164
    Ig; Ig strand A [structural motif]
    cd05892
    Location:12601351
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:10271118
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:11611251
    Ig; Immunoglobulin domain
  2. XM_039094914.1XP_038950842.1  palladin isoform X1

    Conserved Domains (6) summary
    pfam07679
    Location:449546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:11611164
    Ig; Ig strand A [structural motif]
    cd05892
    Location:12601351
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:10271118
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:11611251
    Ig; Immunoglobulin domain
  3. XM_039094915.1XP_038950843.1  palladin isoform X2

    Conserved Domains (6) summary
    pfam07679
    Location:449546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:11441147
    Ig; Ig strand A [structural motif]
    cd05892
    Location:12431334
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:10101101
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:11441234
    Ig; Immunoglobulin domain
  4. XM_039094917.1XP_038950845.1  palladin isoform X4

    Conserved Domains (5) summary
    pfam07679
    Location:59156
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:771774
    Ig; Ig strand A [structural motif]
    cd05892
    Location:870961
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:637728
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:771861
    Ig; Immunoglobulin domain
  5. XM_008771231.3XP_008769453.1  palladin isoform X5

    See identical proteins and their annotated locations for XP_008769453.1

    Conserved Domains (3) summary
    cd00096
    Location:315384
    Ig; Immunoglobulin domain
    cd05893
    Location:548622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432522
    I-set; Immunoglobulin I-set domain
  6. XM_008771232.3XP_008769454.1  palladin isoform X6

    See identical proteins and their annotated locations for XP_008769454.1

    Conserved Domains (3) summary
    cd00096
    Location:298367
    Ig; Immunoglobulin domain
    cd05893
    Location:531605
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:415505
    I-set; Immunoglobulin I-set domain
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