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Tlcd3a TLC domain containing 3A [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360533, updated on 13-Apr-2024

Summary

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Official Symbol
Tlcd3aprovided by RGD
Official Full Name
TLC domain containing 3Aprovided by RGD
Primary source
RGD:1307493
See related
Ensembl:ENSRNOG00000007722 AllianceGenome:RGD:1307493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam57a; RGD1307493
Summary
Predicted to be involved in lipid homeostasis. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TLCD3A (TLC domain containing 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 61.4), Thymus (RPKM 46.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61556193..61563529)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (61057470..61065293)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64360374..64367679)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene VPS53 subunit of GARP complex Neighboring gene uncharacterized LOC103693391 Neighboring gene ribosomal protein L37-like 1 Neighboring gene gem (nuclear organelle) associated protein 4 Neighboring gene diazepam binding inhibitor-like 5 Neighboring gene glyoxalase domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism. He X, et al. Biochem Biophys Res Commun, 2002 Sep 27. PMID 12270127
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TLC domain-containing protein 3A
Names
family with sequence similarity 57, member A
protein FAM57A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399011.2 → NP_001385940.1  TLC domain-containing protein 3A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZT44, A6HGU8
    Related
    ENSRNOP00000082168.1, ENSRNOT00000109770.1
    Conserved Domains (1) summary
    smart00724
    Location:39 → 249
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    61556193..61563529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087346.2 → XP_038943274.2  TLC domain-containing protein 3A isoform X4

  2. XM_063268235.1 → XP_063124305.1  TLC domain-containing protein 3A isoform X4

  3. XM_063268234.1 → XP_063124304.1  TLC domain-containing protein 3A isoform X3

  4. XM_039087348.2 → XP_038943276.1  TLC domain-containing protein 3A isoform X5

  5. XM_039087347.2 → XP_038943275.1  TLC domain-containing protein 3A isoform X1

    UniProtKB/TrEMBL
    A6HGU7
    Conserved Domains (1) summary
    smart00724
    Location:8 → 187
    TLC; TRAM, LAG1 and CLN8 homology domains

  6. XM_063268233.1 → XP_063124303.1  TLC domain-containing protein 3A isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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