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Shisa9 shisa family member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361134, updated on 8-Mar-2024

Summary

Symbol
Shisa9provided by RGD
Full Name
shisa family member 9provided by RGD
Primary source
RGD:2320726
See related
Ensembl:ENSRNOG00000063400 AllianceGenome:RGD:2320726
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable PDZ domain binding activity. Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within regulation of AMPA receptor activity. Predicted to be located in dendritic spine membrane; postsynaptic density; and postsynaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. Orthologous to human SHISA9 (shisa family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 59.8), Lung (RPKM 15.9) and 1 other tissue See more
Orthologs
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Genomic context

Location:
10q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (3842625..4135618, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (3335616..3629334, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (2777675..3072842, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sperm motility kinase 3A like 1 Neighboring gene sperm motility kinase 4A like Neighboring gene uncharacterized LOC108352046 Neighboring gene uncharacterized LOC134480743 Neighboring gene uncharacterized LOC120095014 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene calcineurin-like phosphoesterase domain containing 1 Neighboring gene uncharacterized LOC120095243 Neighboring gene sorting nexin 29

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein shisa-9
Names
shisa homolog 9
shisa homolog 9-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    3842625..4135618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087032.2XP_038942960.1  protein shisa-9 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACW8
    Conserved Domains (1) summary
    pfam13908
    Location:113296
    Shisa; Wnt and FGF inhibitory regulator
  2. XM_039087033.2XP_038942961.1  protein shisa-9 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ATC9
    Related
    ENSRNOP00000097822.1
    Conserved Domains (1) summary
    pfam13908
    Location:113296
    Shisa; Wnt and FGF inhibitory regulator
  3. XM_039087034.2XP_038942962.1  protein shisa-9 isoform X3

    Conserved Domains (1) summary
    pfam13908
    Location:113296
    Shisa; Wnt and FGF inhibitory regulator
  4. XM_039087035.2XP_038942963.1  protein shisa-9 isoform X4

    Conserved Domains (1) summary
    pfam13908
    Location:113271
    Shisa; Wnt and FGF inhibitory regulator
  5. XM_039087036.2XP_038942964.1  protein shisa-9 isoform X5

    Conserved Domains (1) summary
    pfam13908
    Location:113222
    Shisa; Wnt and FGF inhibitory regulator
  6. XM_063270075.1XP_063126145.1  protein shisa-9 isoform X6